Hypervirulent Mycobacterium tuberculosis strain triggers necrotic lung pathology associated with enhanced recruitment of neutrophils in resistant C57BL/6 mice

Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis (Mtb) that in most cases induces irreversible necrosis of lung tissue as a result of excessive inflammatory reactions. The murine model of TB in resistant C57BL/6 mice infected with reference Mtb strains is widely...

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Bibliographic Details
Published in:	PloS one Vol. 12; no. 3; p. e0173715
Main Authors:	Almeida, Fabrício M., Ventura, Thatiana L. B., Amaral, Eduardo P., Ribeiro, Simone C. M., Calixto, Sanderson D., Manhães, Marcelle R., Rezende, Andreza L., Souzal, Giliane S., de Carvalho, Igor S., Silva, Elisangela C., Silva, Juliana Azevedo da, Carvalho, Eulógio C. Q., Kritski, Afranio L., Lasunskaia, Elena B.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 17.03.2017 Public Library of Science (PLoS)
Subjects:	Animal models Animals Bacilli Bacteria Biodegradation Biology and Life Sciences Chronic illnesses Consolidation Cytokines Cytokines - biosynthesis Disease control Fibrosis Health aspects Infectious diseases Inflammation Inflammatory response Interferon Lesions Leukocytes (neutrophilic) Lipids Lung diseases Lungs Macrophages Medicine and Health Sciences Mice Mice, Inbred C57BL Mycobacterium tuberculosis Mycobacterium tuberculosis - growth & development Mycobacterium tuberculosis - pathogenicity Myeloid cells Necrosis Neutrophils - immunology Pathology Recruitment Research and Analysis Methods Risk factors Rodents Strains (organisms) Testing Tuberculosis Tuberculosis, Pulmonary - metabolism Tuberculosis, Pulmonary - microbiology Tuberculosis, Pulmonary - pathology Virulence Virulence (Microbiology) γ-Interferon
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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