Soyfood and isoflavone intake and risk of type 2 diabetes in Vietnamese adults

Background/Objectives: Animal studies have demonstrated that soy isoflavones exert antidiabetic effects. However, evidence regarding the association between soyfood intake, a unique source of isoflavones, and type 2 diabetes remains inconclusive. This study assessed the relationship between habitual...

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Published in:European journal of clinical nutrition Vol. 71; no. 10; pp. 1186 - 1192
Main Authors: Nguyen, C T, Pham, N M, Do, V V, Binns, C W, Hoang, V M, Dang, D A, Lee, A H
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 01.10.2017
Nature Publishing Group
Subjects:
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692/699/2743/137/773
Adult
Adults
Aged
Antidiabetics
Asian people
Beansprouts
Case-Control Studies
Clinical Nutrition
Confidence intervals
Control methods
Daidzein
Demographics
Demography
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - epidemiology
Diabetes Mellitus, Type 2 - etiology
Diabetes Mellitus, Type 2 - prevention & control
Disease prevention
Epidemiology
Feeding Behavior
Female
Genistein
Glycine max
Health aspects
Health risk assessment
Health risks
Hospitals
Humans
Internal Medicine
Isoflavones
Isoflavones - administration & dosage
Isoflavones - blood
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Middle Aged
Nutrition research
original-article
Plant-based beverages
Polyphenols
Public Health
Regression analysis
Risk
Risk Factors
Soy products
Soybean milk
Soybean products
Soybeans
Statistical analysis
Surveys and Questionnaires
Tofu
Type 2 diabetes
Vietnam - epidemiology
Vietnam
ISSN:0954-3007, 1476-5640, 1476-5640
Online Access:Get full text
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Summary:Background/Objectives: Animal studies have demonstrated that soy isoflavones exert antidiabetic effects. However, evidence regarding the association between soyfood intake, a unique source of isoflavones, and type 2 diabetes remains inconclusive. This study assessed the relationship between habitual intakes of soyfoods and major isoflavones and risk of type 2 diabetes in Vietnamese adults. Subjects/Methods: A hospital-based case-control study was conducted in Vietnam during 2013–2015. A total of 599 newly diagnosed diabetic cases (age 40–65 years) and 599 hospital-based controls, frequency matched by age and sex, were recruited in Hanoi, capital city of Vietnam. Information on frequency and quantity of soyfood and isoflavone intake, together with demographics, habitual diet and lifestyle characteristics, was obtained from direct interviews using a validated and reliable questionnaire. Unconditional logistic regression analyses were performed to examine the association between soy variables and type 2 diabetes risk. Results: Higher intake of total soyfoods was significantly associated with a lower risk of type 2 diabetes; the adjusted odds ratio (OR) for the highest versus the lowest intake was 0.31 (95% confidence interval (CI): 0.21–0.46; P <0.001). An inverse dose–response relationship of similar magnitude was also observed for total isoflavone intake (OR: 0.35; 95% CI: 0.24 to 0.49; P <0.001). In addition, inverse associations of specific soyfoods (soy milk, tofu and mung bean sprout) and major isoflavones (daidzein, genistein and glycitein) with the type 2 diabetes risk were evident. Conclusions: Soyfood and isoflavone intake was associated with a lower type 2 diabetes risk in Vietnamese adults.
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ISSN:0954-3007
1476-5640
1476-5640
DOI:10.1038/ejcn.2017.76