atpE Mutation in Mycobacterium tuberculosis Not Always Predictive of Bedaquiline Treatment Failure

We report the emergence of an atpE mutation in a clinical Mycobacterium tuberculosis strain. Genotypic and phenotypic bedaquiline susceptibility testing displayed variable results over time and ultimately were not predictive of treatment outcome. This observation highlights the limits of current gen...

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Bibliographic Details
Published in:Emerging infectious diseases Vol. 28; no. 5; pp. 1062 - 1064
Main Authors: Le Ray, Laure Fournier, Aubry, Alexandra, Sougakoff, Wladimir, Revest, Matthieu, Robert, Jérôme, Bonnet, Isabelle, Veziris, Nicolas, Morel, Florence
Format: Journal Article
Language:English
Published: United States U.S. National Center for Infectious Diseases 01.05.2022
Centers for Disease Control and Prevention
Subjects:
Antimicrobial agents
Antitubercular Agents - pharmacology
Antitubercular Agents - therapeutic use
atpE
bedaquiline
Case studies
Clinical outcomes
Diarylquinolines - pharmacology
Diarylquinolines - therapeutic use
Drug resistance
Drug resistance in microorganisms
Drug therapy
Gene mutations
Genetic aspects
Humans
Laboratories
Life Sciences
MDR TB
Microbial Sensitivity Tests
Mutation
Mutation in
Mycobacterium tuberculosis
Mycobacterium tuberculosis - genetics
Not Always Predictive of Bedaquiline Treatment Failure
Patient outcomes
Research Letter
Rv0678
Treatment Failure
Tuberculosis
Tuberculosis, Multidrug-Resistant - diagnosis
Tuberculosis, Multidrug-Resistant - drug therapy
XDR TB
France
Paris France
bacteria
antimicrobial resistance
atpE
XDR TB
tuberculosis
tuberculosis and other mycobacteria
Rv0678
MDR TB
bedaquiline
quinoline derivative
Multidrug-Resistant
Humans
microbial sensitivity test
Microbial Sensitivity Tests
multidrug resistant tuberculosis
Tuberculosis
genetics
Antitubercular Agents
Mycobacterium tuberculosis
Treatment Failure
Diarylquinolines
tuberculostatic agent
Mutation
human
ISSN:1080-6040, 1080-6059, 1080-6059
Online Access:Get full text
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Description
Summary:We report the emergence of an atpE mutation in a clinical Mycobacterium tuberculosis strain. Genotypic and phenotypic bedaquiline susceptibility testing displayed variable results over time and ultimately were not predictive of treatment outcome. This observation highlights the limits of current genotypic and phenotypic methods for detection of bedaquiline resistance.
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PMCID: PMC9045433
ISSN:1080-6040
1080-6059
1080-6059
DOI:10.3201/eid2805.212517