Body fat percentage and CRP correlates with a composite score of vascular risk markers in healthy, young adults - The Lifestyle, Biomarkers, and Atherosclerosis (LBA) study

Background Identification of early signs of atherosclerosis in young adults have the potential to guide early interventions to prevent later cardiovascular disease. We therefore analyzed measures of vascular structure and function and biomarkers of cardiovascular risk in a sample of young healthy ad...

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Published in:BMC cardiovascular disorders Vol. 20; no. 1; pp. 77 - 10
Main Authors: Pettersson-Pablo, Paul, Cao, Yang, Bäckström, Torbjörn, Nilsson, Torbjörn K., Hurtig-Wennlöf, Anita
Format: Journal Article
Language:English
Published: London BioMed Central 11.02.2020
BioMed Central Ltd
Springer Nature B.V
BMC
Subjects:
Adipose tissue
Adiposity
Adolescent
Adult
Age Factors
Algorithms
Analysis
Angiology
Apolipoproteins
Arteriosclerosis
Atherosclerosis
Atherosclerosis - blood
Atherosclerosis - diagnosis
Atherosclerosis - etiology
Atherosclerosis - physiopathology
Biological markers
Biomarkers
Biomarkers - blood
Birth control
Blood pressure
Blood Transfusion Medicine
Body composition
Body fat
Body fat percentage
C-reactive protein
C-Reactive Protein - analysis
Cardiac Surgery
Cardiology
Cardiovascular disease
Cardiovascular diseases
Cardiovascular risk
Carotid Intima-Media Thickness
Cluster Analysis
CRP
Demographic aspects
Diseases
Endothelial dysfunction
Endothelium
Epidemiology
Female
Glucose
Health aspects
Health Status
Humans
Inflammation - blood
Inflammation - complications
Inflammation - diagnosis
Inflammation Mediators - blood
Insulin
Internal Medicine
Lifestyles
Lipid metabolism
Male
Measurement
Medicine
Medicine & Public Health
Obesity
Obesity - complications
Obesity - diagnosis
Obesity - physiopathology
Population
Prognosis
Pulse Wave Analysis
Research Article
Risk Assessment
Risk Factors
Smokers
Structure-function relationships
Wave propagation
Young Adult
Young adults
Youth
Sweden
United States > US
Cluster analysis
Body fat percentage
CRP
Obesity
Young adults
Cardiovascular risk
Atherosclerosis
Endothelial dysfunction
ISSN:1471-2261, 1471-2261
Online Access:Get full text
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Summary:Background Identification of early signs of atherosclerosis in young adults have the potential to guide early interventions to prevent later cardiovascular disease. We therefore analyzed measures of vascular structure and function and biomarkers of cardiovascular risk in a sample of young healthy adults. Methods Pulse-wave velocity (PWV), carotid-intima media thickness (cIMT) and augmentation index (AIX) were measured in 834 healthy non-smokers (ages 18.0–25.9). Emphasis was put on discriminating between individuals having a vascular structure and function associated with a higher or lower risk, and cluster analysis algorithms were employed to assign the subjects into groups based on these vascular measurements. In addition, a vascular status score (VSS) was calculated by summarizing the results according to quintiles of the vascular measurements. The associations between VSS and cardiovascular biomarkers were examined by regression analyses. Results The cluster analyses did not yield sufficiently distinct clustering (groups of individuals that could be categorized unequivocally as having either a vascular structure and function associated with a higher or lower CVD risk). VSS proved a better classificatory variable. The associations between VSS and biomarkers of cardiovascular risk were analyzed by univariable and multivariable regressions. Only body fat percentage and C-reactive protein (CRP) were independently associated with VSS. Conclusions A VSS calculation, which integrates PWV, cIMT, and AIX measurements is better suited for cardiovascular risk evaluation in young adults than cluster analyses. The independent associations of VSS with body fat percentage and CRP highlight the decisive role of adiposity and systemic inflammation in early atherosclerotic progression and suggests a subordinate role of insulin and lipid metabolism in this age span.
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ISSN:1471-2261
1471-2261
DOI:10.1186/s12872-020-01376-6