Retinal Thickness Measured by Spectral-Domain Optical Coherence Tomography in Eyes Without Retinal Abnormalities: The Beaver Dam Eye Study

To examine relationships of age, sex, and systemic and ocular conditions with retinal thickness measured by spectral-domain ocular coherence tomography (SD OCT) in participants without retinal disease. Longitudinal study. setting: Population-based cohort. study population: Persons aged 43–86 years l...

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Vydané v:American journal of ophthalmology Ročník 159; číslo 3; s. 445 - 456.e1
Hlavní autori: Myers, Chelsea E., Klein, Barbara E.K., Meuer, Stacy M., Swift, Maria K., Chandler, Charles S., Huang, Yijun, Gangaputra, Sapna, Pak, Jeong W., Danis, Ronald P., Klein, Ronald
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States Elsevier Inc 01.03.2015
Elsevier Limited
Predmet:
Adult
Age
Age Distribution
Aged
Aged, 80 and over
Blood pressure
Blood Pressure - physiology
Cataracts
Clinical trials
Confidence intervals
Contrast Sensitivity - physiology
Diabetes
Diabetic retinopathy
Disease
Eye surgery
Eyes & eyesight
Female
Humans
Longitudinal Studies
Male
Methods
Middle Aged
Ophthalmology
Organ Size
Population
Reference Values
Retina
Retina - anatomy & histology
Retinal Diseases - complications
Sex Distribution
Software
Surgery
Tomography, Optical Coherence
Visual Acuity - physiology
Wisconsin
Wisconsin
ISSN:0002-9394, 1879-1891, 1879-1891
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Popis
Shrnutí:To examine relationships of age, sex, and systemic and ocular conditions with retinal thickness measured by spectral-domain ocular coherence tomography (SD OCT) in participants without retinal disease. Longitudinal study. setting: Population-based cohort. study population: Persons aged 43–86 years living in Beaver Dam, Wisconsin in 1988–1990. observation procedures: Retinal thickness was measured via SD OCT at the Beaver Dam Eye Study examination in 2008–2010. Retinal disease was determined by ophthalmoscopy, fundus photography, or SD OCT. main outcome measures: Retinal thickness from the inner limiting membrane to the Bruch membrane. The retina was thickest in the inner circle (mean 334.5 μm) and thinnest in the center subfield (285.4 μm). Mean retinal thickness decreased with age in the inner circle (P < .0001) and outer circle (P < .0001). Adjusting for age, eyes in men had thicker retinas than eyes in women in the center subfield (P < .001) and inner circle (P < .001). Sex, axial length/corneal curvature ratio, and peak expiratory flow rate were associated with center subfield thickness. Sex and peak expiratory flow rate were associated with retinal thickness in the inner circle. Alcohol consumption, age, axial length/corneal curvature ratio, cataract surgery, ocular perfusion pressure, and peak expiratory flow rate were associated with retinal thickness in the outer circle. This study provides data for retinal thickness measures in eyes of individuals aged 63 years and older without retinal disease. This information may be useful for clinical trials involving the effects of interventions on retinal thickness and for comparisons with specific retinal diseases affecting the macula.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0002-9394
1879-1891
1879-1891
DOI:10.1016/j.ajo.2014.11.025