Urinary metabolic phenotyping for Alzheimer’s disease
Finding early disease markers using non-invasive and widely available methods is essential to develop a successful therapy for Alzheimer’s Disease. Few studies to date have examined urine, the most readily available biofluid. Here we report the largest study to date using comprehensive metabolic phe...
Saved in:
| Published in: | Scientific reports Vol. 10; no. 1; pp. 21745 - 17 |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
London
Nature Publishing Group UK
10.12.2020
Nature Publishing Group Nature Portfolio |
| Subjects: | |
| ISSN: | 2045-2322, 2045-2322 |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Finding early disease markers using non-invasive and widely available methods is essential to develop a successful therapy for Alzheimer’s Disease. Few studies to date have examined urine, the most readily available biofluid. Here we report the largest study to date using comprehensive metabolic phenotyping platforms (NMR spectroscopy and UHPLC-MS) to probe the urinary metabolome in-depth in people with Alzheimer’s Disease and Mild Cognitive Impairment. Feature reduction was performed using metabolomic Quantitative Trait Loci, resulting in the list of metabolites associated with the genetic variants. This approach helps accuracy in identification of disease states and provides a route to a plausible mechanistic link to pathological processes. Using these mQTLs we built a Random Forests model, which not only correctly discriminates between people with Alzheimer’s Disease and age-matched controls, but also between individuals with Mild Cognitive Impairment who were later diagnosed with Alzheimer’s Disease and those who were not. Further annotation of top-ranking metabolic features nominated by the trained model revealed the involvement of cholesterol-derived metabolites and small-molecules that were linked to Alzheimer’s pathology in previous studies. |
|---|---|
| AbstractList | Abstract Finding early disease markers using non-invasive and widely available methods is essential to develop a successful therapy for Alzheimer’s Disease. Few studies to date have examined urine, the most readily available biofluid. Here we report the largest study to date using comprehensive metabolic phenotyping platforms (NMR spectroscopy and UHPLC-MS) to probe the urinary metabolome in-depth in people with Alzheimer’s Disease and Mild Cognitive Impairment. Feature reduction was performed using metabolomic Quantitative Trait Loci, resulting in the list of metabolites associated with the genetic variants. This approach helps accuracy in identification of disease states and provides a route to a plausible mechanistic link to pathological processes. Using these mQTLs we built a Random Forests model, which not only correctly discriminates between people with Alzheimer’s Disease and age-matched controls, but also between individuals with Mild Cognitive Impairment who were later diagnosed with Alzheimer’s Disease and those who were not. Further annotation of top-ranking metabolic features nominated by the trained model revealed the involvement of cholesterol-derived metabolites and small-molecules that were linked to Alzheimer’s pathology in previous studies. Finding early disease markers using non-invasive and widely available methods is essential to develop a successful therapy for Alzheimer's Disease. Few studies to date have examined urine, the most readily available biofluid. Here we report the largest study to date using comprehensive metabolic phenotyping platforms (NMR spectroscopy and UHPLC-MS) to probe the urinary metabolome in-depth in people with Alzheimer's Disease and Mild Cognitive Impairment. Feature reduction was performed using metabolomic Quantitative Trait Loci, resulting in the list of metabolites associated with the genetic variants. This approach helps accuracy in identification of disease states and provides a route to a plausible mechanistic link to pathological processes. Using these mQTLs we built a Random Forests model, which not only correctly discriminates between people with Alzheimer's Disease and age-matched controls, but also between individuals with Mild Cognitive Impairment who were later diagnosed with Alzheimer's Disease and those who were not. Further annotation of top-ranking metabolic features nominated by the trained model revealed the involvement of cholesterol-derived metabolites and small-molecules that were linked to Alzheimer's pathology in previous studies. Finding early disease markers using non-invasive and widely available methods is essential to develop a successful therapy for Alzheimer's Disease. Few studies to date have examined urine, the most readily available biofluid. Here we report the largest study to date using comprehensive metabolic phenotyping platforms (NMR spectroscopy and UHPLC-MS) to probe the urinary metabolome in-depth in people with Alzheimer's Disease and Mild Cognitive Impairment. Feature reduction was performed using metabolomic Quantitative Trait Loci, resulting in the list of metabolites associated with the genetic variants. This approach helps accuracy in identification of disease states and provides a route to a plausible mechanistic link to pathological processes. Using these mQTLs we built a Random Forests model, which not only correctly discriminates between people with Alzheimer's Disease and age-matched controls, but also between individuals with Mild Cognitive Impairment who were later diagnosed with Alzheimer's Disease and those who were not. Further annotation of top-ranking metabolic features nominated by the trained model revealed the involvement of cholesterol-derived metabolites and small-molecules that were linked to Alzheimer's pathology in previous studies.Finding early disease markers using non-invasive and widely available methods is essential to develop a successful therapy for Alzheimer's Disease. Few studies to date have examined urine, the most readily available biofluid. Here we report the largest study to date using comprehensive metabolic phenotyping platforms (NMR spectroscopy and UHPLC-MS) to probe the urinary metabolome in-depth in people with Alzheimer's Disease and Mild Cognitive Impairment. Feature reduction was performed using metabolomic Quantitative Trait Loci, resulting in the list of metabolites associated with the genetic variants. This approach helps accuracy in identification of disease states and provides a route to a plausible mechanistic link to pathological processes. Using these mQTLs we built a Random Forests model, which not only correctly discriminates between people with Alzheimer's Disease and age-matched controls, but also between individuals with Mild Cognitive Impairment who were later diagnosed with Alzheimer's Disease and those who were not. Further annotation of top-ranking metabolic features nominated by the trained model revealed the involvement of cholesterol-derived metabolites and small-molecules that were linked to Alzheimer's pathology in previous studies. |
| ArticleNumber | 21745 |
| Author | Gómez-Romero, María Jiménez, Beatriz D’Hondt, Ellie Snowden, Stuart Legido-Quigley, Cristina Brazma, Alvis Whiley, Luke Hye, Abdul Vellas, Bruno Chekmeneva, Elena Tsolaki, Magda Proitsi, Petroula Soininen, Hilkka Liu, Benjamine Aarsland, Dag Holmes, Elaine Kłoszewska, Iwona Kimhofer, Torben Kurbatova, Natalja Nicholson, Jeremy K. Garg, Manik Mecocci, Patrizia Nevado-Holgado, Alejo Lewis, Matthew R. Pearce, Jake Ashton, Nicholas J. Lovestone, Simon |
| Author_xml | – sequence: 1 givenname: Natalja surname: Kurbatova fullname: Kurbatova, Natalja email: natalja@ebi.ac.uk organization: European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI – sequence: 2 givenname: Manik surname: Garg fullname: Garg, Manik organization: European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI – sequence: 3 givenname: Luke surname: Whiley fullname: Whiley, Luke organization: Department of Metabolism, Digestion and Reproduction, National Phenome Centre, Imperial College London, UK Dementia Research Institute, Hammersmith Hospital, Imperial College London – sequence: 4 givenname: Elena surname: Chekmeneva fullname: Chekmeneva, Elena organization: Department of Metabolism, Digestion and Reproduction, National Phenome Centre, Imperial College London – sequence: 5 givenname: Beatriz surname: Jiménez fullname: Jiménez, Beatriz organization: Department of Metabolism, Digestion and Reproduction, National Phenome Centre, Imperial College London – sequence: 6 givenname: María surname: Gómez-Romero fullname: Gómez-Romero, María organization: Department of Metabolism, Digestion and Reproduction, National Phenome Centre, Imperial College London – sequence: 7 givenname: Jake surname: Pearce fullname: Pearce, Jake organization: Department of Metabolism, Digestion and Reproduction, National Phenome Centre, Imperial College London – sequence: 8 givenname: Torben surname: Kimhofer fullname: Kimhofer, Torben organization: Division of Systems Medicine, Imperial College London – sequence: 9 givenname: Ellie surname: D’Hondt fullname: D’Hondt, Ellie organization: IMEC – sequence: 10 givenname: Hilkka surname: Soininen fullname: Soininen, Hilkka organization: Department of Neurology, University of Eastern Finland and Kuopio University Hospital – sequence: 11 givenname: Iwona surname: Kłoszewska fullname: Kłoszewska, Iwona organization: Medical University of Lodz – sequence: 12 givenname: Patrizia surname: Mecocci fullname: Mecocci, Patrizia organization: Institute of Gerontology and Geriatrics, University of Perugia – sequence: 13 givenname: Magda surname: Tsolaki fullname: Tsolaki, Magda organization: 3rd Department of Neurology, Aristotle University – sequence: 14 givenname: Bruno surname: Vellas fullname: Vellas, Bruno organization: INSERM U 558, University of Toulouse – sequence: 15 givenname: Dag surname: Aarsland fullname: Aarsland, Dag organization: King’s College London, Institute of Psychiatry, Psychology and Neuroscience – sequence: 16 givenname: Alejo surname: Nevado-Holgado fullname: Nevado-Holgado, Alejo organization: Department of Psychiatry, Warneford Hospital, University of Oxford – sequence: 17 givenname: Benjamine surname: Liu fullname: Liu, Benjamine organization: Department of Psychiatry, Warneford Hospital, University of Oxford – sequence: 18 givenname: Stuart surname: Snowden fullname: Snowden, Stuart organization: King’s College London, Institute of Psychiatry, Psychology and Neuroscience – sequence: 19 givenname: Petroula surname: Proitsi fullname: Proitsi, Petroula organization: King’s College London, Institute of Psychiatry, Psychology and Neuroscience – sequence: 20 givenname: Nicholas J. surname: Ashton fullname: Ashton, Nicholas J. organization: King’s College London, Institute of Psychiatry, Psychology and Neuroscience, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation – sequence: 21 givenname: Abdul surname: Hye fullname: Hye, Abdul organization: King’s College London, Institute of Psychiatry, Psychology and Neuroscience – sequence: 22 givenname: Cristina surname: Legido-Quigley fullname: Legido-Quigley, Cristina organization: King’s College London, Institute of Psychiatry, Psychology and Neuroscience – sequence: 23 givenname: Matthew R. surname: Lewis fullname: Lewis, Matthew R. organization: Department of Metabolism, Digestion and Reproduction, National Phenome Centre, Imperial College London – sequence: 24 givenname: Jeremy K. surname: Nicholson fullname: Nicholson, Jeremy K. organization: Department of Metabolism, Digestion and Reproduction, National Phenome Centre, Imperial College London, Health Futures Institute, Murdoch University – sequence: 25 givenname: Elaine surname: Holmes fullname: Holmes, Elaine organization: UK Dementia Research Institute, Hammersmith Hospital, Imperial College London, Health Futures Institute, Murdoch University, The Perron Institute for Neurological and Translational Science – sequence: 26 givenname: Alvis surname: Brazma fullname: Brazma, Alvis organization: European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI – sequence: 27 givenname: Simon surname: Lovestone fullname: Lovestone, Simon organization: Department of Psychiatry, Warneford Hospital, University of Oxford, Janssen-Cilag Ltd |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33303834$$D View this record in MEDLINE/PubMed https://hal.science/hal-04500786$$DView record in HAL https://gup.ub.gu.se/publication/301559$$DView record from Swedish Publication Index (Göteborgs universitet) http://kipublications.ki.se/Default.aspx?queryparsed=id:145683734$$DView record from Swedish Publication Index (Karolinska Institutet) |
| BookMark | eNp9ks1u1DAUhSNUREvpC7BAI7GBRcC_ib1BGlVAK43Epqwt27nJeEjiwU6KyorX4PV4EpxmKJ1ZTDaxrr9z7tX1eZ6d9L6HLHuJ0TuMqHgfGeZS5IigvBSI4lw-yc4IYjwnlJCTR-fT7CLGDUofJ5Jh-Sw7pZQmD8rOsvJrcL0Od4sOBm186-xiu4beD3db1zeL2ofFsv25BtdB-PPrd1xULoKO8CJ7Wus2wsXuf57dfPp4c3mVr758vr5crnJb4mLITS1QwYnhYAjWEgoQtiDYotJAzSphCgRCVhbTWltjqCkp1dyAkciSQtPz7Hq2rbzeqG1wXZpVee3UfcGHRukwONuCwqYSvC6wrHjJEOdGlxbXhknJC1PB5JXPXvEHbEez57YrfUsnUKzgkqGjfDNuVSo148RThDmXif8w8wnuoLLQD0G3e7L9m96tVeNvVVkmB8GSwdvZYH0gu1qu1FRLL4pQKYpbnNg3u2bBfx8hDqpz0ULb6h78GBVhJSKCEjGhrw_QjR9Dn15tolISCOdT81ePp3_o_y8qCSAzYIOPMUD9gGCkpkiqOZIqRVLdR1JNOxEHIusGPTg_bcC1x6V0t_7Up28g_B_7iOovm072Vw |
| CitedBy_id | crossref_primary_10_1186_s40246_024_00704_7 crossref_primary_10_3389_fneur_2022_968193 crossref_primary_10_1016_j_microc_2025_115234 crossref_primary_10_3233_JAD_230946 crossref_primary_10_3233_ADR_220071 crossref_primary_10_1007_s10143_024_02381_5 crossref_primary_10_1016_j_arr_2025_102736 crossref_primary_10_1002_nbm_4638 crossref_primary_10_1038_s41392_023_01399_3 crossref_primary_10_1186_s13024_022_00548_6 crossref_primary_10_3389_fnagi_2023_1273807 crossref_primary_10_3390_metabo12020181 crossref_primary_10_1007_s12035_023_03578_3 crossref_primary_10_1016_j_envint_2024_108462 crossref_primary_10_3390_pharmaceutics14081532 crossref_primary_10_1007_s11055_025_01838_4 crossref_primary_10_1016_j_nbd_2023_106312 crossref_primary_10_1186_s12967_021_03032_9 crossref_primary_10_1186_s13023_021_02075_x crossref_primary_10_3389_fphar_2024_1423060 crossref_primary_10_3390_antiox10091353 crossref_primary_10_1002_prca_202200107 crossref_primary_10_1016_j_jbc_2022_102706 crossref_primary_10_1016_j_jchromb_2025_124746 crossref_primary_10_3389_fneur_2021_719159 crossref_primary_10_3389_fmolb_2023_1308500 |
| Cites_doi | 10.1086/519795 10.1016/j.jocn.2014.10.011 10.1515/CCLM.2011.792 10.1016/j.dadm.2017.07.006 10.1002/hep.22371 10.2217/fnl.12.31 10.2741/4248 10.1093/geronj/25.2.98 10.1021/acs.analchem.9b00241 10.1016/j.bcp.2013.11.009 10.3390/metabo7020028 10.1006/hbeh.2001.1677 10.1093/bioinformatics/btz566 10.1097/MEG.0b013e3283470256 10.1007/s11306-017-1297-5 10.1172/jci.insight.99676 10.1093/brain/awl279 10.1016/j.jinorgbio.2014.01.015 10.1093/nar/gky1120 10.1038/s41598-019-42992-3 10.1021/ac5025039 10.1093/bioinformatics/19.2.185 10.1161/RES.0b013e3182290620 10.1016/S1474-4422(16)00070-3 10.3233/JAD-2010-100354 10.1126/science.1223813 10.1016/j.patrec.2005.10.010 10.1038/ng.837 10.2337/db11-1186 10.1038/nm.3466 10.1111/j.2517-6161.1995.tb02031.x 10.1016/j.gpb.2015.08.005 10.1021/acs.analchem.6b01481 10.1111/j.1749-6632.2009.05063.x 10.1021/acs.jproteome.7b00206 10.1371/journal.pmed.1001713 10.1186/s13195-016-0208-8 10.3164/jcbn.12-118 10.1371/journal.pone.0021643 10.1016/j.lfs.2007.02.030 10.1097/01.ftd.0000179845.53213.39 10.1016/j.jalz.2018.07.217 10.1007/s40279-016-0558-1 10.1111/j.1749-6632.2009.05064.x 10.1038/tp.2014.35 10.1371/journal.pone.0116221 10.1007/s00401-019-01991-4 10.1038/s41598-017-17999-3 10.1002/gps.1810 10.1016/j.copbio.2018.07.010 10.1371/journal.pgen.1004132 10.1016/j.bbr.2018.05.005 10.1016/0960-0760(96)00080-5 10.1371/journal.pgen.1002270 10.3109/1354750X.2014.994036 10.1016/j.jalz.2016.09.014 10.1016/j.jalz.2017.09.011 10.1023/A:1010933404324 10.1016/j.jalz.2016.08.003 10.1093/bioinformatics/bts163 10.1016/j.cca.2015.07.017 10.1038/srep02364 10.1186/s40478-018-0567-4 10.1109/34.709601 10.1093/nar/gkl923 10.1016/j.jalz.2013.04.506 10.1161/ATVBAHA.109.192971 10.3390/nu10111765 10.1021/pr500828v 10.1038/s41598-017-19116-w 10.1172/JCI115806 10.1016/j.jalz.2016.09.002 10.1111/jnc.13912 10.3233/JAD-190408 10.3389/fneur.2015.00237 10.1523/JNEUROSCI.3359-12.2012 10.1038/s41598-017-13601-y 10.1016/j.jnim.2017.03.002 10.1186/s40478-018-0649-3 10.1038/tp.2013.13 10.1371/journal.pgen.1005487 10.1186/gm329 10.1038/npp.2013.154 10.1534/g3.111.001198 10.1021/acsomega.7b00872 10.1038/tp.2015.205 10.1016/j.jalz.2015.12.008 10.1038/srep19495 10.1016/j.neuroscience.2015.08.018 10.1109/ICDAR.1995.598994 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2020 The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Attribution |
| Copyright_xml | – notice: The Author(s) 2020 – notice: The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: Attribution |
| DBID | C6C AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7X7 7XB 88A 88E 88I 8FE 8FH 8FI 8FJ 8FK ABUWG AEUYN AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M1P M2P M7P PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI Q9U 7X8 1XC VOOES 5PM ADTPV AOWAS F1U D8T ZZAVC DOA |
| DOI | 10.1038/s41598-020-78031-9 |
| DatabaseName | SpringerOpen Free (Free internet resource, activated by CARLI) CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Science Database (Alumni Edition) ProQuest SciTech Collection ProQuest Natural Science Journals ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection Medical Database Science Database Biological Science Database ProQuest Central Premium ProQuest One Academic (New) ProQuest Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central Basic MEDLINE - Academic Hyper Article en Ligne (HAL) Hyper Article en Ligne (HAL) (Open Access) PubMed Central (Full Participant titles) SwePub SwePub Articles SWEPUB Göteborgs universitet SWEPUB Freely available online SwePub Articles full text DOAJ Directory of Open Access Journals - Free |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central ProQuest One Applied & Life Sciences ProQuest One Sustainability ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Publicly Available Content Database MEDLINE - Academic CrossRef MEDLINE |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 2045-2322 |
| EndPage | 17 |
| ExternalDocumentID | oai_doaj_org_article_1bd85f619d574055ba7c1fb49956bdea oai_swepub_ki_se_465940 oai_gup_ub_gu_se_301559 PMC7730184 oai:HAL:hal-04500786v1 33303834 10_1038_s41598_020_78031_9 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GrantInformation_xml | – fundername: Medical Research Council, UK, and National Institute for Health Research, England grantid: MC_PC_12025 – fundername: Projekt DEAL – fundername: Innovative Medicines Initiative grantid: 115372 funderid: http://dx.doi.org/10.13039/501100010767 – fundername: Medical Research Council grantid: MC_PC_12025 – fundername: Department of Health – fundername: ; – fundername: ; grantid: 115372 – fundername: ; grantid: MC_PC_12025 |
| GroupedDBID | 0R~ 3V. 4.4 53G 5VS 7X7 88A 88E 88I 8FE 8FH 8FI 8FJ AAFWJ AAJSJ AAKDD ABDBF ABUWG ACGFS ACSMW ACUHS ADBBV ADRAZ AENEX AEUYN AFKRA AJTQC ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BAWUL BBNVY BCNDV BENPR BHPHI BPHCQ BVXVI C6C CCPQU DIK DWQXO EBD EBLON EBS ESX FYUFA GNUQQ GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE KQ8 LK8 M0L M1P M2P M48 M7P M~E NAO OK1 PIMPY PQQKQ PROAC PSQYO RNT RNTTT RPM SNYQT UKHRP AASML AAYXX AFFHD AFPKN CITATION PHGZM PHGZT PJZUB PPXIY PQGLB CGR CUY CVF ECM EIF NPM 7XB 8FK K9. PKEHL PQEST PQUKI Q9U 7X8 PUEGO 1XC VOOES 5PM ADTPV AOWAS EJD F1U IPNFZ RIG D8T ZZAVC |
| ID | FETCH-LOGICAL-c716t-bf80652b5eb21a9e6e8c621c07bef4d8b60e89dc13facbb3b733a5beb90c26a3 |
| IEDL.DBID | DOA |
| ISICitedReferencesCount | 30 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000609195000101&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 2045-2322 |
| IngestDate | Fri Oct 03 12:32:42 EDT 2025 Tue Nov 25 03:29:00 EST 2025 Tue Nov 04 16:54:41 EST 2025 Tue Nov 04 01:52:13 EST 2025 Sat Oct 25 07:18:28 EDT 2025 Thu Sep 04 18:40:47 EDT 2025 Tue Oct 07 08:23:57 EDT 2025 Thu Apr 03 07:07:14 EDT 2025 Tue Nov 18 22:06:34 EST 2025 Sat Nov 29 04:03:03 EST 2025 Fri Feb 21 02:38:50 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | Biomarkers Metabolomics Alzheimer's disease Genomics Dementia |
| Language | English |
| License | Attribution: http://creativecommons.org/licenses/by Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c716t-bf80652b5eb21a9e6e8c621c07bef4d8b60e89dc13facbb3b733a5beb90c26a3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 PMCID: PMC7730184 |
| ORCID | 0000-0002-7678-5065 |
| OpenAccessLink | https://doaj.org/article/1bd85f619d574055ba7c1fb49956bdea |
| PMID | 33303834 |
| PQID | 2473302554 |
| PQPubID | 2041939 |
| PageCount | 17 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_1bd85f619d574055ba7c1fb49956bdea swepub_primary_oai_swepub_ki_se_465940 swepub_primary_oai_gup_ub_gu_se_301559 pubmedcentral_primary_oai_pubmedcentral_nih_gov_7730184 hal_primary_oai_HAL_hal_04500786v1 proquest_miscellaneous_2470283281 proquest_journals_2473302554 pubmed_primary_33303834 crossref_primary_10_1038_s41598_020_78031_9 crossref_citationtrail_10_1038_s41598_020_78031_9 springer_journals_10_1038_s41598_020_78031_9 |
| PublicationCentury | 2000 |
| PublicationDate | 2020-12-10 |
| PublicationDateYYYYMMDD | 2020-12-10 |
| PublicationDate_xml | – month: 12 year: 2020 text: 2020-12-10 day: 10 |
| PublicationDecade | 2020 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | Scientific reports |
| PublicationTitleAbbrev | Sci Rep |
| PublicationTitleAlternate | Sci Rep |
| PublicationYear | 2020 |
| Publisher | Nature Publishing Group UK Nature Publishing Group Nature Portfolio |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group – name: Nature Portfolio |
| References | Vogt (CR15) 2017; 7 Dong, Brewer (CR71) 2019; 71 Ho (CR88) 1998; 20 Lovestone (CR22) 2009; 1180 Purcell (CR84) 2007; 81 Wang (CR7) 2015; 20 Lindsay, Costello (CR11) 2017; 47 Marschall (CR50) 1992; 89 Foy (CR75) 2007; 22 Kimball, Wilson, Wesson (CR17) 2016; 6 Giau (CR16) 2018; 10 Shabalin (CR80) 2012; 28 Bolstad, Irizarry, Astrand, Speed (CR83) 2003; 19 Aslibekyan (CR69) 2017; 8 CR79 Zengi (CR10) 2011; 50 An (CR56) 2018; 14 Karpievitch, Nikolic, Wilson, Sharman, Edwards (CR82) 2014; 9 Hye (CR23) 2006; 129 Suhre (CR26) 2011; 43 Sands (CR77) 2019; 35 Pan (CR58) 2017; 7 Reitz (CR33) 2013; 3 Igarashi, Yoshida, Waragai, Kashiwagi (CR9) 2015; 450 Paterson (CR30) 2009; 29 O’Bryant (CR4) 2017; 13 Fitzgerald (CR73) 2017; 2 Reitz (CR34) 2012; 7 Wishart (CR92) 2007; 35 Robinette, Dumas (CR25) 2012 Rueedi (CR28) 2014; 10 Newton (CR40) 2011; 23 Ruiz, Bruick (CR43) 2014; 133 Wang (CR64) 2018; 3 Rajagopal, Soni, Meltzer (CR61) 2018; 350 Olsson (CR5) 2016; 15 Borin (CR39) 2018; 6 Ashton (CR6) 2019; 7 Carvalho (CR66) 2012; 61 Ma (CR8) 2015; 22 Castillo (CR46) 2017; 7 CR87 Horowitz, Greenamyre (CR44) 2010; 20 Estep, Wong, Wong, Loui, Riccomagno (CR38) 2018 An, Gao (CR13) 2015; 13 Breiman (CR86) 2001; 45 Mez (CR37) 2017; 13 Yu (CR20) 2017; 16 Lane (CR35) 2012; 32 Han (CR59) 2011; 6 Casanova (CR55) 2016; 12 Blennow, Hampel, Zetterberg (CR2) 2014; 39 Hua (CR67) 2007; 80 Proitsi (CR24) 2014; 11 Romanoff, Thomas, Baxter (CR62) 1970; 25 Whiley (CR31) 2019; 91 Fukuhara (CR19) 2013; 52 Lewis (CR78) 2016; 88 Howie, Marchini, Stephens (CR85) 2011; 1 Joseph (CR68) 2011; 109 Hampel (CR1) 2014; 88 Dona (CR76) 2014; 86 Miyashita (CR45) 2014; 4 Simmons (CR21) 2009; 1180 Fiandaca (CR52) 2015 Voyle (CR54) 2016; 6 Newton (CR41) 2008; 48 Gareth, Witten, Hastie, Tibshirani (CR89) 2013 Smith (CR91) 2005; 27 Raffler (CR29) 2015; 11 Benjamini, Hochberg (CR81) 1995; 57 Nicholson (CR27) 2011; 7 Proitsi (CR57) 2017; 13 Ellison, Abner, Lovell (CR72) 2017; 140 Chaleckis, Meister, Zhang, Wheelock (CR32) 2019; 55 Roszkowski (CR12) 2014; 19 Campion, Charbonnier, Nicolas (CR36) 2019; 138 Mayo, Le Moal, Abrous (CR60) 2001; 40 Nicholson (CR14) 2012; 336 Lista (CR3) 2014; 10 Peng (CR18) 2014; 13 Öhrfelt (CR47) 2016; 8 Inoue (CR74) 2013; 3 Dastgheib, Dehpour, Heidari, Moezi (CR42) 2015; 306 Buniello (CR48) 2019; 47 Mapstone (CR51) 2014; 20 Marksteiner, Blasko, Kemmler, Koal, Humpel (CR63) 2018 Fawcett (CR90) 2006; 27 Velenosi (CR70) 2019; 9 de Leeuw (CR53) 2017; 8 Meng, Griffiths, Sjövall (CR49) 1996; 58 MahmoudianDehkordi (CR65) 2019; 15 TK Ho (78031_CR88) 1998; 20 MS Fiandaca (78031_CR52) 2015 TJ Velenosi (78031_CR70) 2019; 9 BL Fitzgerald (78031_CR73) 2017; 2 JL Newton (78031_CR41) 2008; 48 CJ Sands (78031_CR77) 2019; 35 J Mez (78031_CR37) 2017; 13 CML Foy (78031_CR75) 2007; 22 S Aslibekyan (78031_CR69) 2017; 8 EM Ellison (78031_CR72) 2017; 140 J Yu (78031_CR20) 2017; 16 FA de Leeuw (78031_CR53) 2017; 8 D Campion (78031_CR36) 2019; 138 K Inoue (78031_CR74) 2013; 3 N Voyle (78031_CR54) 2016; 6 S Purcell (78031_CR84) 2007; 81 JK Nicholson (78031_CR14) 2012; 336 C Smith (78031_CR91) 2005; 27 G Nicholson (78031_CR27) 2011; 7 HU Marschall (78031_CR50) 1992; 89 A Lindsay (78031_CR11) 2017; 47 Y An (78031_CR56) 2018; 14 LP Romanoff (78031_CR62) 1970; 25 A Simmons (78031_CR21) 2009; 1180 DS Wishart (78031_CR92) 2007; 35 J Raffler (78031_CR29) 2015; 11 K Roszkowski (78031_CR12) 2014; 19 AC Dona (78031_CR76) 2014; 86 K Blennow (78031_CR2) 2014; 39 JA Estep (78031_CR38) 2018 J Marksteiner (78031_CR63) 2018 Y Benjamini (78031_CR81) 1995; 57 X Hua (78031_CR67) 2007; 80 AD Paterson (78031_CR30) 2009; 29 L Whiley (78031_CR31) 2019; 91 R Chaleckis (78031_CR32) 2019; 55 VV Giau (78031_CR16) 2018; 10 P Proitsi (78031_CR24) 2014; 11 P Proitsi (78031_CR57) 2017; 13 L Breiman (78031_CR86) 2001; 45 O Zengi (78031_CR10) 2011; 50 BA Kimball (78031_CR17) 2016; 6 LJ Meng (78031_CR49) 1996; 58 C Carvalho (78031_CR66) 2012; 61 Loscalzo Joseph (78031_CR68) 2011; 109 78031_CR79 RF Lane (78031_CR35) 2012; 32 M Borin (78031_CR39) 2018; 6 K Igarashi (78031_CR9) 2015; 450 NJ Ashton (78031_CR6) 2019; 7 MR Lewis (78031_CR78) 2016; 88 X Pan (78031_CR58) 2017; 7 AA Shabalin (78031_CR80) 2012; 28 B Olsson (78031_CR5) 2016; 15 M An (78031_CR13) 2015; 13 A Buniello (78031_CR48) 2019; 47 YV Karpievitch (78031_CR82) 2014; 9 C Wang (78031_CR7) 2015; 20 SL Robinette (78031_CR25) 2012 A Hye (78031_CR23) 2006; 129 JC Ruiz (78031_CR43) 2014; 133 R Casanova (78031_CR55) 2016; 12 A Öhrfelt (78031_CR47) 2016; 8 B Howie (78031_CR85) 2011; 1 L Rajagopal (78031_CR61) 2018; 350 SE O’Bryant (78031_CR4) 2017; 13 J Peng (78031_CR18) 2014; 13 NM Vogt (78031_CR15) 2017; 7 K Suhre (78031_CR26) 2011; 43 T Fawcett (78031_CR90) 2006; 27 R Rueedi (78031_CR28) 2014; 10 S Lovestone (78031_CR22) 2009; 1180 H Hampel (78031_CR1) 2014; 88 C Reitz (78031_CR33) 2013; 3 BM Bolstad (78031_CR83) 2003; 19 78031_CR87 E Castillo (78031_CR46) 2017; 7 L Ma (78031_CR8) 2015; 22 A Miyashita (78031_CR45) 2014; 4 S Lista (78031_CR3) 2014; 10 K Fukuhara (78031_CR19) 2013; 52 M Dastgheib (78031_CR42) 2015; 306 J Gareth (78031_CR89) 2013 JL Newton (78031_CR40) 2011; 23 S MahmoudianDehkordi (78031_CR65) 2019; 15 Y Dong (78031_CR71) 2019; 71 MP Horowitz (78031_CR44) 2010; 20 M Mapstone (78031_CR51) 2014; 20 W Mayo (78031_CR60) 2001; 40 Y Wang (78031_CR64) 2018; 3 C Reitz (78031_CR34) 2012; 7 X Han (78031_CR59) 2011; 6 |
| References_xml | – volume: 81 start-page: 559 year: 2007 end-page: 575 ident: CR84 article-title: PLINK: A toolset for whole-genome association and population-based linkage analysis publication-title: Am. J. Hum. Genet. doi: 10.1086/519795 – volume: 22 start-page: 649 year: 2015 end-page: 652 ident: CR8 article-title: The level of Alzheimer-associated neuronal thread protein in urine may be an important biomarker of mild cognitive impairment publication-title: J. Clin. Neurosci. Off. J. Neurosurg. Soc. Aust. doi: 10.1016/j.jocn.2014.10.011 – volume: 50 start-page: 529 year: 2011 end-page: 534 ident: CR10 article-title: Urinary 8-hydroxy-2’-deoxyguanosine level and plasma paraoxonase 1 activity with Alzheimer’s disease publication-title: Clin. Chem. Lab. Med. doi: 10.1515/CCLM.2011.792 – volume: 8 start-page: 196 year: 2017 end-page: 207 ident: CR53 article-title: Blood-based metabolic signatures in Alzheimer’s disease publication-title: Alzheimer’s Dementia Diag. Assess. Disease Monit. doi: 10.1016/j.dadm.2017.07.006 – volume: 48 start-page: 541 year: 2008 end-page: 549 ident: CR41 article-title: Cognitive impairment in primary biliary cirrhosis: Symptom impact and potential etiology publication-title: Hepatology doi: 10.1002/hep.22371 – volume: 7 start-page: 423 year: 2012 end-page: 431 ident: CR34 article-title: The role of intracellular trafficking and the VPS10d receptors in Alzheimer’s disease publication-title: Future Neurol. doi: 10.2217/fnl.12.31 – volume: 19 start-page: 808 year: 2014 end-page: 817 ident: CR12 article-title: Oxidative DNA damage-the possible use of biomarkers as additional prognostic factors in oncology publication-title: Front. Biosci. (Landmark Edn.) doi: 10.2741/4248 – volume: 25 start-page: 98 year: 1970 end-page: 101 ident: CR62 article-title: Effect of age on pregnanediol excretion by men publication-title: J. Gerontol. doi: 10.1093/geronj/25.2.98 – ident: CR87 – volume: 91 start-page: 8873 year: 2019 end-page: 8882 ident: CR31 article-title: Systematic isolation and structure elucidation of urinary metabolites optimized for the analytical-scale molecular profiling laboratory publication-title: Analyt. Chem. doi: 10.1021/acs.analchem.9b00241 – volume: 88 start-page: 426 year: 2014 end-page: 449 ident: CR1 article-title: Perspective on future role of biological markers in clinical therapy trials of Alzheimer’s disease: A long-range point of view beyond 2020 publication-title: Biochem. Pharmacol. doi: 10.1016/j.bcp.2013.11.009 – volume: 7 start-page: 28 year: 2017 ident: CR58 article-title: Metabolomic profiling of bile acids in clinical and experimental samples of Alzheimer’s disease publication-title: Metabolites doi: 10.3390/metabo7020028 – volume: 40 start-page: 215 year: 2001 end-page: 217 ident: CR60 article-title: Pregnenolone sulfate and aging of cognitive functions: Behavioral, neurochemical, and morphological investigations publication-title: Hormones Behav. doi: 10.1006/hbeh.2001.1677 – volume: 35 start-page: 5359 year: 2019 end-page: 5360 ident: CR77 article-title: The nPYc-toolbox, a python module for the pre-processing, quality-control and analysis of metabolic profiling datasets publication-title: Bioinformatics doi: 10.1093/bioinformatics/btz566 – volume: 23 start-page: 566 year: 2011 end-page: 572 ident: CR40 article-title: Functional capacity is significantly impaired in primary biliary cirrhosis and is related to orthostatic symptoms publication-title: Eur. J. Gastroenterol. Hepatol. doi: 10.1097/MEG.0b013e3283470256 – year: 2018 ident: CR63 article-title: Bile acid quantification of 20 plasma metabolites identifies lithocholic acid as a putative biomarker in Alzheimer’s disease publication-title: Metabolomics. doi: 10.1007/s11306-017-1297-5 – volume: 3 start-page: e99676 issue: 8 year: 2018 ident: CR64 article-title: Bile acids regulate cysteine catabolism and glutathione regeneration to modulate hepatic sensitivity to oxidative injury publication-title: JCI Insight. doi: 10.1172/jci.insight.99676 – volume: 129 start-page: 3042 year: 2006 end-page: 3050 ident: CR23 article-title: Proteome-based plasma biomarkers for Alzheimer’s disease publication-title: Brain J. Neurol. doi: 10.1093/brain/awl279 – volume: 133 start-page: 73 year: 2014 end-page: 77 ident: CR43 article-title: F-box and leucine-rich repeat protein 5 (FBXL5): Sensing intracellular iron and oxygen publication-title: J. Inorg. Biochem. doi: 10.1016/j.jinorgbio.2014.01.015 – volume: 47 start-page: D1005 year: 2019 end-page: D1012 ident: CR48 article-title: The NHGRI-EBI GWAS catalog of published genome-wide association studies, targeted arrays and summary statistics 2019 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gky1120 – volume: 9 start-page: 1 year: 2019 end-page: 13 ident: CR70 article-title: Untargeted metabolomics reveals N,N,N-trimethyl- -alanyl- -proline betaine (TMAP) as a novel biomarker of kidney function publication-title: Sci. Rep. doi: 10.1038/s41598-019-42992-3 – volume: 86 start-page: 9887 year: 2014 end-page: 9894 ident: CR76 article-title: Precision high-throughput proton NMR spectroscopy of human urine, serum, and plasma for large-scale metabolic phenotyping publication-title: Analyt. Chem. doi: 10.1021/ac5025039 – volume: 19 start-page: 185 year: 2003 end-page: 193 ident: CR83 article-title: A comparison of normalization methods for high density oligonucleotide array data based on variance and bias publication-title: Bioinformatics doi: 10.1093/bioinformatics/19.2.185 – volume: 109 start-page: 127 year: 2011 end-page: 129 ident: CR68 article-title: Lipid metabolism by gut microbes and atherosclerosis publication-title: Circ. Res. doi: 10.1161/RES.0b013e3182290620 – volume: 15 start-page: 673 year: 2016 end-page: 684 ident: CR5 article-title: CSF and blood biomarkers for the diagnosis of Alzheimer’s disease: A systematic review and meta-analysis publication-title: Lancet Neurol. doi: 10.1016/S1474-4422(16)00070-3 – volume: 20 start-page: S551 issue: Suppl 2 year: 2010 end-page: 568 ident: CR44 article-title: Mitochondrial iron metabolism and its role in neurodegeneration publication-title: J. Alzheimer’s Dis. JAD doi: 10.3233/JAD-2010-100354 – volume: 336 start-page: 1262 year: 2012 end-page: 1267 ident: CR14 article-title: Host-gut microbiota metabolic interactions publication-title: Science doi: 10.1126/science.1223813 – volume: 27 start-page: 861 year: 2006 end-page: 874 ident: CR90 article-title: An introduction to ROC analysis publication-title: Pattern Recognit. Lett. doi: 10.1016/j.patrec.2005.10.010 – volume: 43 start-page: 565 year: 2011 end-page: 569 ident: CR26 article-title: A genome-wide association study of metabolic traits in human urine publication-title: Nat. Genet. doi: 10.1038/ng.837 – volume: 61 start-page: 1234 year: 2012 end-page: 1242 ident: CR66 article-title: Metabolic alterations induced by sucrose intake and Alzheimer’s disease promote similar brain mitochondrial abnormalities publication-title: Diabetes doi: 10.2337/db11-1186 – volume: 20 start-page: 415 year: 2014 end-page: 418 ident: CR51 article-title: Plasma phospholipids identify antecedent memory impairment in older adults publication-title: Nat. Med. doi: 10.1038/nm.3466 – volume: 57 start-page: 289 year: 1995 end-page: 300 ident: CR81 article-title: Controlling the false discovery rate: A practical and powerful approach to multiple testing publication-title: J. R. Stat. Soc. Series B (Methodol.) doi: 10.1111/j.2517-6161.1995.tb02031.x – volume: 13 start-page: 345 year: 2015 end-page: 354 ident: CR13 article-title: Urinary biomarkers of brain diseases publication-title: Genom. Proteom. Bioinform. doi: 10.1016/j.gpb.2015.08.005 – volume: 88 start-page: 9004 year: 2016 end-page: 9013 ident: CR78 article-title: Development and application of ultra-performance liquid chromatography-TOF MS for precision large scale urinary metabolic phenotyping publication-title: Analyt. Chem. doi: 10.1021/acs.analchem.6b01481 – volume: 1180 start-page: 47 year: 2009 end-page: 55 ident: CR21 article-title: MRI measures of Alzheimer’s disease and the AddNeuroMed study publication-title: Ann. N. Y. Acad. Sci. doi: 10.1111/j.1749-6632.2009.05063.x – volume: 16 start-page: 3219 year: 2017 end-page: 3228 ident: CR20 article-title: High-throughput metabolomics for discovering potential metabolite biomarkers and metabolic mechanism from the APPswe/PS1dE9 transgenic model of Alzheimer’s disease publication-title: J. Proteome Res. doi: 10.1021/acs.jproteome.7b00206 – volume: 11 start-page: e1001713 year: 2014 ident: CR24 article-title: Genetic predisposition to increased blood cholesterol and triglyceride lipid levels and risk of Alzheimer disease: A mendelian randomization analysis publication-title: PLoS Med. doi: 10.1371/journal.pmed.1001713 – volume: 8 start-page: 41 year: 2016 ident: CR47 article-title: The pre-synaptic vesicle protein synaptotagmin is a novel biomarker for Alzheimer’s disease publication-title: Alzheimer’s Res. Ther. doi: 10.1186/s13195-016-0208-8 – volume: 52 start-page: 133 year: 2013 end-page: 138 ident: CR19 article-title: NMR-based metabolomics of urine in a mouse model of Alzheimer’s disease: Identification of oxidative stress biomarkers publication-title: J. Clin. Biochem. Nutr. doi: 10.3164/jcbn.12-118 – volume: 6 start-page: e21643 year: 2011 ident: CR59 article-title: Metabolomics in early Alzheimer’s disease: Identification of altered plasma sphingolipidome using shotgun lipidomics publication-title: PLOS ONE doi: 10.1371/journal.pone.0021643 – volume: 80 start-page: 1897 year: 2007 end-page: 1905 ident: CR67 article-title: Long-term -galactose injection combined with ovariectomy serves as a new rodent model for Alzheimer’s disease publication-title: Life Sci. doi: 10.1016/j.lfs.2007.02.030 – volume: 27 start-page: 747 year: 2005 end-page: 751 ident: CR91 article-title: METLIN: A metabolite mass spectral database publication-title: Therap. Drug Monit. doi: 10.1097/01.ftd.0000179845.53213.39 – volume: 15 start-page: 76 year: 2019 end-page: 92 ident: CR65 article-title: Altered bile acid profile associates with cognitive impairment in Alzheimer’s disease-an emerging role for gut microbiome publication-title: Alzheimer’s Dementia J. Alzheimer’s Assoc. doi: 10.1016/j.jalz.2018.07.217 – volume: 47 start-page: 11 year: 2017 end-page: 31 ident: CR11 article-title: Realising the potential of urine and saliva as diagnostic tools in sport and exercise medicine publication-title: Sports Med. (Auckland, N.Z.) doi: 10.1007/s40279-016-0558-1 – volume: 1180 start-page: 36 year: 2009 end-page: 46 ident: CR22 article-title: AddNeuroMed-the European collaboration for the discovery of novel biomarkers for Alzheimer’s disease publication-title: Ann. N. Y. Acad. Sci. doi: 10.1111/j.1749-6632.2009.05064.x – volume: 4 start-page: e396 year: 2014 ident: CR45 article-title: Genes associated with the progression of neurofibrillary tangles in Alzheimer’s disease publication-title: Transl. Psychiatry doi: 10.1038/tp.2014.35 – volume: 9 start-page: e116221 year: 2014 ident: CR82 article-title: Metabolomics data normalization with EigenMS publication-title: PLoS One doi: 10.1371/journal.pone.0116221 – volume: 138 start-page: 173 year: 2019 end-page: 186 ident: CR36 article-title: SORL1 genetic variants and Alzheimer disease risk: A literature review and meta-analysis of sequencing data publication-title: Acta Neuropathol. doi: 10.1007/s00401-019-01991-4 – volume: 7 start-page: 17762 year: 2017 ident: CR46 article-title: Comparative profiling of cortical gene expression in Alzheimer’s disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation publication-title: Sci. Rep. doi: 10.1038/s41598-017-17999-3 – volume: 22 start-page: 1154 year: 2007 end-page: 1163 ident: CR75 article-title: Diagnosing Alzheimer’s disease-non-clinicians and computerised algorithms together are as accurate as the best clinical practice publication-title: Int. J. Geriatric Psychiatry doi: 10.1002/gps.1810 – volume: 55 start-page: 44 year: 2019 end-page: 50 ident: CR32 article-title: Challenges, progress and promises of metabolite annotation for LC–MS-based metabolomics publication-title: Curr. Opin. Biotechnol. doi: 10.1016/j.copbio.2018.07.010 – volume: 10 start-page: e1004132 year: 2014 ident: CR28 article-title: Genome-wide association study of metabolic traits reveals novel gene-metabolite-disease links publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1004132 – volume: 350 start-page: 31 year: 2018 end-page: 43 ident: CR61 article-title: Neurosteroid pregnenolone sulfate, alone, and as augmentation of lurasidone or tandospirone, rescues phencyclidine-induced deficits in cognitive function and social interaction publication-title: Behav. Brain Res. doi: 10.1016/j.bbr.2018.05.005 – volume: 58 start-page: 585 year: 1996 end-page: 598 ident: CR49 article-title: The identification of novel steroid N-acetylglucosaminides in the urine of pregnant women publication-title: J. Steroid Biochem. Mol. Biol. doi: 10.1016/0960-0760(96)00080-5 – volume: 7 start-page: e1002270 year: 2011 ident: CR27 article-title: A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1002270 – volume: 20 start-page: 84 year: 2015 end-page: 88 ident: CR7 article-title: Combining serum and urine biomarkers in the early diagnosis of mild cognitive impairment that evolves into Alzheimer’s disease in patients with the apolipoprotein E 4 genotype publication-title: Biomarkers Biochem. Indicators Exposure Response Suscept. Chem. doi: 10.3109/1354750X.2014.994036 – volume: 13 start-page: 45 year: 2017 end-page: 58 ident: CR4 article-title: Blood-based biomarkers in Alzheimer disease: Current state of the science and a novel collaborative paradigm for advancing from discovery to clinic publication-title: Alzheimer’s Dementia J. Alzheimer’s Assoc. doi: 10.1016/j.jalz.2016.09.014 – volume: 14 start-page: 318 year: 2018 end-page: 329 ident: CR56 article-title: Evidence for brain glucose dysregulation in Alzheimer’s disease publication-title: Alzheimer’s Dementia doi: 10.1016/j.jalz.2017.09.011 – volume: 45 start-page: 5 year: 2001 end-page: 32 ident: CR86 article-title: Random forests publication-title: Mach. Learn. doi: 10.1023/A:1010933404324 – volume: 13 start-page: 140 year: 2017 end-page: 151 ident: CR57 article-title: Association of blood lipids with Alzheimer’s disease: A comprehensive lipidomics analysis publication-title: Alzheimer’s Dementia doi: 10.1016/j.jalz.2016.08.003 – volume: 28 start-page: 1353 year: 2012 end-page: 1358 ident: CR80 article-title: Matrix eQTL: Ultra fast eQTL analysis via large matrix operations publication-title: Bioinformatics doi: 10.1093/bioinformatics/bts163 – volume: 450 start-page: 56 year: 2015 end-page: 63 ident: CR9 article-title: Evaluation of dementia by acrolein, amyloid- and creatinine publication-title: Clin. Chim. Acta Int. J. Clin. Chem. doi: 10.1016/j.cca.2015.07.017 – volume: 3 start-page: 1 year: 2013 end-page: 9 ident: CR74 article-title: Metabolic profiling of Alzheimer’s disease brains publication-title: Sci. Rep. doi: 10.1038/srep02364 – ident: CR79 – volume: 6 start-page: 61 year: 2018 ident: CR39 article-title: Rac1 activation links tau hyperphosphorylation and a dysmetabolism in Alzheimer’s disease publication-title: Acta Neuropathol. Commun. doi: 10.1186/s40478-018-0567-4 – volume: 20 start-page: 832 year: 1998 end-page: 844 ident: CR88 article-title: The random subspace method for constructing decision forests publication-title: IEEE Trans. Pattern Anal. Mach. Intell. doi: 10.1109/34.709601 – volume: 35 start-page: D521 year: 2007 end-page: D526 ident: CR92 article-title: HMDB: The human metabolome database publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkl923 – volume: 10 start-page: 381 year: 2014 end-page: 392 ident: CR3 article-title: CSF A 1–42 combined with neuroimaging biomarkers in the early detection, diagnosis and prediction of Alzheimer’s disease publication-title: Alzheimer’s Dementia doi: 10.1016/j.jalz.2013.04.506 – volume: 29 start-page: 1958 year: 2009 end-page: 1967 ident: CR30 article-title: Genome-wide association identifies the ABO blood group as a major locus associated with serum levels of soluble E-selectin publication-title: Arteriosclerosis Thromb. Vasc. Biol. doi: 10.1161/ATVBAHA.109.192971 – volume: 10 start-page: 1765 year: 2018 ident: CR16 article-title: Gut microbiota and their neuroinflammatory implications in Alzheimer’s disease publication-title: Nutrients doi: 10.3390/nu10111765 – volume: 13 start-page: 4457 year: 2014 end-page: 4469 ident: CR18 article-title: Development of isotope labeling liquid chromatography mass spectrometry for mouse urine metabolomics: Quantitative metabolomic study of transgenic mice related to Alzheimer’s disease publication-title: J. Proteome Res. doi: 10.1021/pr500828v – year: 2013 ident: CR89 publication-title: Introduction to Statistical Learning – year: 2018 ident: CR38 article-title: The RacGAP -Chimaerin is essential for cerebellar granule cell migration publication-title: Sci. Rep. doi: 10.1038/s41598-017-19116-w – volume: 89 start-page: 1981 year: 1992 end-page: 1987 ident: CR50 article-title: Bile acid n-acetylglucosaminidation. in vivo and in vitro evidence for a selective conjugation reaction of 7 beta-hydroxylated bile acids in humans publication-title: J. Clin. Invest. doi: 10.1172/JCI115806 – volume: 13 start-page: 119 year: 2017 end-page: 129 ident: CR37 article-title: Two novel loci, COBL and SLC10a2, for Alzheimer’s disease in African Americans publication-title: Alzheimer’s Dementia J. Alzheimer’s Assoc. doi: 10.1016/j.jalz.2016.09.002 – volume: 140 start-page: 383 year: 2017 end-page: 394 ident: CR72 article-title: Multiregional analysis of global 5-methylcytosine and 5-hydroxymethylcytosine throughout the progression of Alzheimer’s disease publication-title: J. Neurochem. doi: 10.1111/jnc.13912 – volume: 71 start-page: 119 year: 2019 end-page: 140 ident: CR71 article-title: Global metabolic shifts in age and Alzheimer’s disease mouse brains pivot at NAD+/NADH redox sites publication-title: J. Alzheimer’s Dis. doi: 10.3233/JAD-190408 – year: 2015 ident: CR52 article-title: Plasma 24-metabolite panel predicts preclinical transition to clinical stages of Alzheimer’s disease publication-title: Front. Neurol. doi: 10.3389/fneur.2015.00237 – volume: 32 start-page: 14080 year: 2012 end-page: 14086 ident: CR35 article-title: Vps10 family proteins and the retromer complex in aging-related neurodegeneration and diabetes publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.3359-12.2012 – volume: 7 start-page: 1 year: 2017 end-page: 11 ident: CR15 article-title: Gut microbiome alterations in Alzheimer’s disease publication-title: Sci. Rep. doi: 10.1038/s41598-017-13601-y – volume: 8 start-page: 1 year: 2017 end-page: 7 ident: CR69 article-title: Genome- and CD4+ T-cell methylome-wide association study of circulating trimethylamine-N-oxide in the genetics of lipid lowering drugs and diet network (GOLDN) publication-title: J. Nutr. Intermediary Metab. doi: 10.1016/j.jnim.2017.03.002 – volume: 7 start-page: 5 year: 2019 ident: CR6 article-title: Increased plasma neurofilament light chain concentration correlates with severity of post-mortem neurofibrillary tangle pathology and neurodegeneration publication-title: Acta Neuropathol. Commun. doi: 10.1186/s40478-018-0649-3 – volume: 3 start-page: e256 year: 2013 ident: CR33 article-title: Independent and epistatic effects of variants in VPS10-d receptors on Alzheimer disease risk and processing of the amyloid precursor protein (APP) publication-title: Transl. Psychiatry doi: 10.1038/tp.2013.13 – volume: 11 start-page: e1005487 year: 2015 ident: CR29 article-title: Genome-wide association study with targeted and non-targeted NMR metabolomics identifies 15 novel loci of urinary human metabolic individuality publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1005487 – year: 2012 ident: CR25 article-title: Genetic determinants of metabolism in health and disease: From biochemical genetics to genome-wide associations publication-title: Genome Med. doi: 10.1186/gm329 – volume: 39 start-page: 189 year: 2014 end-page: 201 ident: CR2 article-title: Biomarkers in Amyloid- immunotherapy trials in Alzheimer’s disease publication-title: Neuropsychopharmacology doi: 10.1038/npp.2013.154 – volume: 1 start-page: 457 year: 2011 end-page: 470 ident: CR85 article-title: Genotype imputation with thousands of genomes publication-title: G3 Genet. Genes Genom. doi: 10.1534/g3.111.001198 – volume: 2 start-page: 3921 year: 2017 end-page: 3930 ident: CR73 article-title: Elucidating the structure of N1-acetylisoputreanine: A novel polyamine catabolite in human urine publication-title: ACS Omega doi: 10.1021/acsomega.7b00872 – volume: 6 start-page: e719 year: 2016 end-page: e719 ident: CR54 article-title: Blood metabolite markers of neocortical amyloid- burden: Discovery and enrichment using candidate proteins publication-title: Transl. Psychiatry doi: 10.1038/tp.2015.205 – volume: 12 start-page: 815 year: 2016 end-page: 822 ident: CR55 article-title: Blood metabolite markers of preclinical Alzheimer’s disease in two longitudinally followed cohorts of older individuals publication-title: Alzheimer’s Dementia J. Alzheimer’s Assoc. doi: 10.1016/j.jalz.2015.12.008 – volume: 6 start-page: 19495 year: 2016 ident: CR17 article-title: Alterations of the volatile metabolome in mouse models of Alzheimer’s disease publication-title: Sci. Rep. doi: 10.1038/srep19495 – volume: 306 start-page: 1 year: 2015 end-page: 9 ident: CR42 article-title: The effects of intra-dorsal hippocampus infusion of pregnenolone sulfate on memory function and hippocampal BDNF mRNA expression of biliary cirrhosis-induced memory impairment in rats publication-title: Neuroscience doi: 10.1016/j.neuroscience.2015.08.018 – volume: 7 start-page: 28 year: 2017 ident: 78031_CR58 publication-title: Metabolites doi: 10.3390/metabo7020028 – volume: 7 start-page: 17762 year: 2017 ident: 78031_CR46 publication-title: Sci. Rep. doi: 10.1038/s41598-017-17999-3 – volume: 13 start-page: 140 year: 2017 ident: 78031_CR57 publication-title: Alzheimer’s Dementia doi: 10.1016/j.jalz.2016.08.003 – volume: 22 start-page: 649 year: 2015 ident: 78031_CR8 publication-title: J. Clin. Neurosci. Off. J. Neurosurg. Soc. Aust. doi: 10.1016/j.jocn.2014.10.011 – volume: 19 start-page: 808 year: 2014 ident: 78031_CR12 publication-title: Front. Biosci. (Landmark Edn.) doi: 10.2741/4248 – volume: 6 start-page: e21643 year: 2011 ident: 78031_CR59 publication-title: PLOS ONE doi: 10.1371/journal.pone.0021643 – volume: 43 start-page: 565 year: 2011 ident: 78031_CR26 publication-title: Nat. Genet. doi: 10.1038/ng.837 – volume: 58 start-page: 585 year: 1996 ident: 78031_CR49 publication-title: J. Steroid Biochem. Mol. Biol. doi: 10.1016/0960-0760(96)00080-5 – volume: 3 start-page: e99676 issue: 8 year: 2018 ident: 78031_CR64 publication-title: JCI Insight. doi: 10.1172/jci.insight.99676 – volume: 89 start-page: 1981 year: 1992 ident: 78031_CR50 publication-title: J. Clin. Invest. doi: 10.1172/JCI115806 – volume: 91 start-page: 8873 year: 2019 ident: 78031_CR31 publication-title: Analyt. Chem. doi: 10.1021/acs.analchem.9b00241 – year: 2018 ident: 78031_CR38 publication-title: Sci. Rep. doi: 10.1038/s41598-017-19116-w – volume: 40 start-page: 215 year: 2001 ident: 78031_CR60 publication-title: Hormones Behav. doi: 10.1006/hbeh.2001.1677 – volume: 35 start-page: 5359 year: 2019 ident: 78031_CR77 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btz566 – volume: 13 start-page: 345 year: 2015 ident: 78031_CR13 publication-title: Genom. Proteom. Bioinform. doi: 10.1016/j.gpb.2015.08.005 – volume: 2 start-page: 3921 year: 2017 ident: 78031_CR73 publication-title: ACS Omega doi: 10.1021/acsomega.7b00872 – volume: 28 start-page: 1353 year: 2012 ident: 78031_CR80 publication-title: Bioinformatics doi: 10.1093/bioinformatics/bts163 – volume: 9 start-page: e116221 year: 2014 ident: 78031_CR82 publication-title: PLoS One doi: 10.1371/journal.pone.0116221 – volume: 3 start-page: 1 year: 2013 ident: 78031_CR74 publication-title: Sci. Rep. doi: 10.1038/srep02364 – volume: 7 start-page: e1002270 year: 2011 ident: 78031_CR27 publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1002270 – volume: 10 start-page: e1004132 year: 2014 ident: 78031_CR28 publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1004132 – volume: 13 start-page: 45 year: 2017 ident: 78031_CR4 publication-title: Alzheimer’s Dementia J. Alzheimer’s Assoc. doi: 10.1016/j.jalz.2016.09.014 – volume: 7 start-page: 423 year: 2012 ident: 78031_CR34 publication-title: Future Neurol. doi: 10.2217/fnl.12.31 – volume: 55 start-page: 44 year: 2019 ident: 78031_CR32 publication-title: Curr. Opin. Biotechnol. doi: 10.1016/j.copbio.2018.07.010 – volume: 13 start-page: 119 year: 2017 ident: 78031_CR37 publication-title: Alzheimer’s Dementia J. Alzheimer’s Assoc. doi: 10.1016/j.jalz.2016.09.002 – volume: 20 start-page: S551 issue: Suppl 2 year: 2010 ident: 78031_CR44 publication-title: J. Alzheimer’s Dis. JAD doi: 10.3233/JAD-2010-100354 – volume: 350 start-page: 31 year: 2018 ident: 78031_CR61 publication-title: Behav. Brain Res. doi: 10.1016/j.bbr.2018.05.005 – volume: 1180 start-page: 36 year: 2009 ident: 78031_CR22 publication-title: Ann. N. Y. Acad. Sci. doi: 10.1111/j.1749-6632.2009.05064.x – volume: 3 start-page: e256 year: 2013 ident: 78031_CR33 publication-title: Transl. Psychiatry doi: 10.1038/tp.2013.13 – volume: 23 start-page: 566 year: 2011 ident: 78031_CR40 publication-title: Eur. J. Gastroenterol. Hepatol. doi: 10.1097/MEG.0b013e3283470256 – volume: 7 start-page: 1 year: 2017 ident: 78031_CR15 publication-title: Sci. Rep. doi: 10.1038/s41598-017-13601-y – volume: 20 start-page: 415 year: 2014 ident: 78031_CR51 publication-title: Nat. Med. doi: 10.1038/nm.3466 – volume: 1 start-page: 457 year: 2011 ident: 78031_CR85 publication-title: G3 Genet. Genes Genom. doi: 10.1534/g3.111.001198 – volume: 50 start-page: 529 year: 2011 ident: 78031_CR10 publication-title: Clin. Chem. Lab. Med. doi: 10.1515/CCLM.2011.792 – volume: 6 start-page: 19495 year: 2016 ident: 78031_CR17 publication-title: Sci. Rep. doi: 10.1038/srep19495 – volume: 81 start-page: 559 year: 2007 ident: 78031_CR84 publication-title: Am. J. Hum. Genet. doi: 10.1086/519795 – volume: 140 start-page: 383 year: 2017 ident: 78031_CR72 publication-title: J. Neurochem. doi: 10.1111/jnc.13912 – volume: 86 start-page: 9887 year: 2014 ident: 78031_CR76 publication-title: Analyt. Chem. doi: 10.1021/ac5025039 – volume: 27 start-page: 747 year: 2005 ident: 78031_CR91 publication-title: Therap. Drug Monit. doi: 10.1097/01.ftd.0000179845.53213.39 – volume: 35 start-page: D521 year: 2007 ident: 78031_CR92 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkl923 – volume: 27 start-page: 861 year: 2006 ident: 78031_CR90 publication-title: Pattern Recognit. Lett. doi: 10.1016/j.patrec.2005.10.010 – volume: 450 start-page: 56 year: 2015 ident: 78031_CR9 publication-title: Clin. Chim. Acta Int. J. Clin. Chem. doi: 10.1016/j.cca.2015.07.017 – volume: 1180 start-page: 47 year: 2009 ident: 78031_CR21 publication-title: Ann. N. Y. Acad. Sci. doi: 10.1111/j.1749-6632.2009.05063.x – year: 2012 ident: 78031_CR25 publication-title: Genome Med. doi: 10.1186/gm329 – volume: 11 start-page: e1005487 year: 2015 ident: 78031_CR29 publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1005487 – volume-title: Introduction to Statistical Learning year: 2013 ident: 78031_CR89 – volume: 15 start-page: 76 year: 2019 ident: 78031_CR65 publication-title: Alzheimer’s Dementia J. Alzheimer’s Assoc. doi: 10.1016/j.jalz.2018.07.217 – volume: 15 start-page: 673 year: 2016 ident: 78031_CR5 publication-title: Lancet Neurol. doi: 10.1016/S1474-4422(16)00070-3 – volume: 12 start-page: 815 year: 2016 ident: 78031_CR55 publication-title: Alzheimer’s Dementia J. Alzheimer’s Assoc. doi: 10.1016/j.jalz.2015.12.008 – volume: 10 start-page: 381 year: 2014 ident: 78031_CR3 publication-title: Alzheimer’s Dementia doi: 10.1016/j.jalz.2013.04.506 – volume: 8 start-page: 1 year: 2017 ident: 78031_CR69 publication-title: J. Nutr. Intermediary Metab. doi: 10.1016/j.jnim.2017.03.002 – volume: 22 start-page: 1154 year: 2007 ident: 78031_CR75 publication-title: Int. J. Geriatric Psychiatry doi: 10.1002/gps.1810 – volume: 47 start-page: 11 year: 2017 ident: 78031_CR11 publication-title: Sports Med. (Auckland, N.Z.) doi: 10.1007/s40279-016-0558-1 – volume: 11 start-page: e1001713 year: 2014 ident: 78031_CR24 publication-title: PLoS Med. doi: 10.1371/journal.pmed.1001713 – volume: 71 start-page: 119 year: 2019 ident: 78031_CR71 publication-title: J. Alzheimer’s Dis. doi: 10.3233/JAD-190408 – volume: 8 start-page: 196 year: 2017 ident: 78031_CR53 publication-title: Alzheimer’s Dementia Diag. Assess. Disease Monit. doi: 10.1016/j.dadm.2017.07.006 – volume: 32 start-page: 14080 year: 2012 ident: 78031_CR35 publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.3359-12.2012 – volume: 88 start-page: 426 year: 2014 ident: 78031_CR1 publication-title: Biochem. Pharmacol. doi: 10.1016/j.bcp.2013.11.009 – volume: 80 start-page: 1897 year: 2007 ident: 78031_CR67 publication-title: Life Sci. doi: 10.1016/j.lfs.2007.02.030 – volume: 8 start-page: 41 year: 2016 ident: 78031_CR47 publication-title: Alzheimer’s Res. Ther. doi: 10.1186/s13195-016-0208-8 – ident: 78031_CR79 – volume: 16 start-page: 3219 year: 2017 ident: 78031_CR20 publication-title: J. Proteome Res. doi: 10.1021/acs.jproteome.7b00206 – volume: 9 start-page: 1 year: 2019 ident: 78031_CR70 publication-title: Sci. Rep. doi: 10.1038/s41598-019-42992-3 – volume: 19 start-page: 185 year: 2003 ident: 78031_CR83 publication-title: Bioinformatics doi: 10.1093/bioinformatics/19.2.185 – volume: 45 start-page: 5 year: 2001 ident: 78031_CR86 publication-title: Mach. Learn. doi: 10.1023/A:1010933404324 – volume: 10 start-page: 1765 year: 2018 ident: 78031_CR16 publication-title: Nutrients doi: 10.3390/nu10111765 – volume: 57 start-page: 289 year: 1995 ident: 78031_CR81 publication-title: J. R. Stat. Soc. Series B (Methodol.) doi: 10.1111/j.2517-6161.1995.tb02031.x – volume: 133 start-page: 73 year: 2014 ident: 78031_CR43 publication-title: J. Inorg. Biochem. doi: 10.1016/j.jinorgbio.2014.01.015 – volume: 129 start-page: 3042 year: 2006 ident: 78031_CR23 publication-title: Brain J. Neurol. doi: 10.1093/brain/awl279 – volume: 336 start-page: 1262 year: 2012 ident: 78031_CR14 publication-title: Science doi: 10.1126/science.1223813 – volume: 25 start-page: 98 year: 1970 ident: 78031_CR62 publication-title: J. Gerontol. doi: 10.1093/geronj/25.2.98 – volume: 306 start-page: 1 year: 2015 ident: 78031_CR42 publication-title: Neuroscience doi: 10.1016/j.neuroscience.2015.08.018 – volume: 13 start-page: 4457 year: 2014 ident: 78031_CR18 publication-title: J. Proteome Res. doi: 10.1021/pr500828v – volume: 6 start-page: 61 year: 2018 ident: 78031_CR39 publication-title: Acta Neuropathol. Commun. doi: 10.1186/s40478-018-0567-4 – volume: 39 start-page: 189 year: 2014 ident: 78031_CR2 publication-title: Neuropsychopharmacology doi: 10.1038/npp.2013.154 – year: 2018 ident: 78031_CR63 publication-title: Metabolomics. doi: 10.1007/s11306-017-1297-5 – volume: 29 start-page: 1958 year: 2009 ident: 78031_CR30 publication-title: Arteriosclerosis Thromb. Vasc. Biol. doi: 10.1161/ATVBAHA.109.192971 – volume: 48 start-page: 541 year: 2008 ident: 78031_CR41 publication-title: Hepatology doi: 10.1002/hep.22371 – volume: 47 start-page: D1005 year: 2019 ident: 78031_CR48 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gky1120 – volume: 88 start-page: 9004 year: 2016 ident: 78031_CR78 publication-title: Analyt. Chem. doi: 10.1021/acs.analchem.6b01481 – volume: 52 start-page: 133 year: 2013 ident: 78031_CR19 publication-title: J. Clin. Biochem. Nutr. doi: 10.3164/jcbn.12-118 – volume: 61 start-page: 1234 year: 2012 ident: 78031_CR66 publication-title: Diabetes doi: 10.2337/db11-1186 – year: 2015 ident: 78031_CR52 publication-title: Front. Neurol. doi: 10.3389/fneur.2015.00237 – ident: 78031_CR87 doi: 10.1109/ICDAR.1995.598994 – volume: 20 start-page: 84 year: 2015 ident: 78031_CR7 publication-title: Biomarkers Biochem. Indicators Exposure Response Suscept. Chem. doi: 10.3109/1354750X.2014.994036 – volume: 109 start-page: 127 year: 2011 ident: 78031_CR68 publication-title: Circ. Res. doi: 10.1161/RES.0b013e3182290620 – volume: 138 start-page: 173 year: 2019 ident: 78031_CR36 publication-title: Acta Neuropathol. doi: 10.1007/s00401-019-01991-4 – volume: 7 start-page: 5 year: 2019 ident: 78031_CR6 publication-title: Acta Neuropathol. Commun. doi: 10.1186/s40478-018-0649-3 – volume: 6 start-page: e719 year: 2016 ident: 78031_CR54 publication-title: Transl. Psychiatry doi: 10.1038/tp.2015.205 – volume: 14 start-page: 318 year: 2018 ident: 78031_CR56 publication-title: Alzheimer’s Dementia doi: 10.1016/j.jalz.2017.09.011 – volume: 4 start-page: e396 year: 2014 ident: 78031_CR45 publication-title: Transl. Psychiatry doi: 10.1038/tp.2014.35 – volume: 20 start-page: 832 year: 1998 ident: 78031_CR88 publication-title: IEEE Trans. Pattern Anal. Mach. Intell. doi: 10.1109/34.709601 |
| SSID | ssj0000529419 |
| Score | 2.4804661 |
| Snippet | Finding early disease markers using non-invasive and widely available methods is essential to develop a successful therapy for Alzheimer’s Disease. Few studies... Finding early disease markers using non-invasive and widely available methods is essential to develop a successful therapy for Alzheimer's Disease. Few studies... Abstract Finding early disease markers using non-invasive and widely available methods is essential to develop a successful therapy for Alzheimer’s Disease.... |
| SourceID | doaj swepub pubmedcentral hal proquest pubmed crossref springer |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 21745 |
| SubjectTerms | 631/61/212 631/61/320 692/53 692/699/375/132 692/699/375/132/1283 Aged Aged, 80 and over Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer Disease - urine Alzheimer's disease amyloid-beta association bile-acids biomarkers Biomarkers - urine Cholesterol Cognitive ability Cognitive Dysfunction - genetics Cognitive Dysfunction - metabolism Cognitive Dysfunction - urine cognitive impairment discovery Female Gene mapping Genetic diversity Genetic variance gut microbiota Humanities and Social Sciences Humans Life Sciences Magnetic resonance spectroscopy Male Metabolism Metabolites Metabolomics Metabolomics - methods mouse models multidisciplinary Neurodegenerative diseases Neurosciences Neurovetenskaper NMR Nuclear magnetic resonance Phenotype Phenotyping pregnenolone sulfate primary biliary-cirrhosis Quantitative Trait Loci Santé publique et épidémiologie Science Science & Technology - Other Topics Science (multidisciplinary) |
| SummonAdditionalLinks | – databaseName: Science Database dbid: M2P link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELaggMSF92OhoIAQF4ia2Elsn9CCqHooVQ9F6s2yHWd3xTZZNruVyom_wd_jlzDjeFOFir1wdcaJ4xmPP3tehLyhhRRGVjquEp1gUm0dy1LomOpKJNaC3jQ-Zf4hPzoSp6fyOFy4tcGtcqMTvaIuG4t35Hs043D0BgCcfVh8j7FqFFpXQwmN6-QGIJsUXbq-0OP-jgWtWFkqQ6xMwsReC_sVxpRRdKMDeY7lYD_yafthl5miU-RVxHnVcbK3nv6VadTvTvt3__e_7pE7AZdG406Q7pNrrn5AbnWVKi8eEv516QN3ozO3ArGZz2yEzmHN6gLjrSJAvtF4_mPqZmdu-fvnrzYKhp9H5GT_88mngzjUXIgtnJxWsanQ0kpNDifuVEtXOGELmtqEG1dlpTBF4oQsbcoqbY1hBkavc-OMTCwtNHtMduqmdk9JRFmmGddGZy5DG76m0gjHS7SlJnmZj0i6mXhlQz5yLIsxV94uzoTqmKWAWcozS8kRedf3WXTZOLZSf0R-9pSYSds3NMuJCgtTpaYUeQXHyDLnMK7caG7TymQY8WtKp0fkNUjD4B0H40OFbYCGEWEV5-mI7G6Yq4IOaNUlZ0fkVf8YVi-aZHTtmrWn8cWiBLziSSdb_acY9GaCQW8-kLrBWIZP6tnUZwjnqLcF9Hy_kc_LYW2br7edDA--MFkvFDRN1qp1iiHE_gdhaPo2Q8KsyGWWPNs-L8_JbYpLMaWABnbJzmq5di_ITXu-mrXLl34t_wE7nlHt priority: 102 providerName: ProQuest |
| Title | Urinary metabolic phenotyping for Alzheimer’s disease |
| URI | https://link.springer.com/article/10.1038/s41598-020-78031-9 https://www.ncbi.nlm.nih.gov/pubmed/33303834 https://www.proquest.com/docview/2473302554 https://www.proquest.com/docview/2470283281 https://hal.science/hal-04500786 https://pubmed.ncbi.nlm.nih.gov/PMC7730184 https://gup.ub.gu.se/publication/301559 http://kipublications.ki.se/Default.aspx?queryparsed=id:145683734 https://doaj.org/article/1bd85f619d574055ba7c1fb49956bdea |
| Volume | 10 |
| WOSCitedRecordID | wos000609195000101&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: DOA dateStart: 20110101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: M~E dateStart: 20110101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: M7P dateStart: 20110101 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: 7X7 dateStart: 20110101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: BENPR dateStart: 20110101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: PIMPY dateStart: 20110101 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVPQU databaseName: Science Database customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: M2P dateStart: 20110101 isFulltext: true titleUrlDefault: https://search.proquest.com/sciencejournals providerName: ProQuest |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3NbtQwELagBYlLxW8JlFVAiAtETewkto9b1KpI7SpCRVpOlu043RXb3Wo3W6k98Rq8Hk_CjJNdGirKhYsPzjg_M-PMjMbzDSFvaS6FkZWOqljHCKqtI1kKHVFdidha-G8aD5l_xAcDMRzK4lqrLzwT1sADN4zbTUwpsgrc_DLj4FxkRnObVCbFikxTOu8axVxeC6YaVG8q00S2VTIxE7sLsFRYTUbxAB1ociQ7lsgD9oN9GeFxyJu-5s0jk-u86R8Yo94uHTwkW61DGfabD3lE7rjpY3K_aTF5-YTwL3NfcRueuRrkPRnbEE91zepLLJQKwWUN-5OrkRufufnP7z8WYZuxeUpODvZPPh5GbbOEyELIU0emwhQpNRmEyomWLnfC5jSxMTeuSkth8tgJWdqEVdoawwxnTGfGGRlbmmv2jGxMZ1P3nISUpZpxbXTqUky-ayqNcLzEJGiclVlAkhXflG2BxLGfxUT5hDYTquG1Al4rz2slA_J-vea8gdG4lXoPxbGmRAhsPwGKoVrFUP9SjIC8AWF27nHYP1I4B24sukb5RRKQnZWsVbt5F4qmwBuMtdKAvF5fhm2HuRQ9dbOlp_FdngTcYrtRjfWjGKyGwB9W847SdN6le2U6Hnlob44_XAErP6zU6_dr3cavd40Kdp5wujxXMHW6VAunGPrGfyFsp76NkTDNM5nGL_6HBF6SBxT3W0LB2O-QjXq-dK_IPXtRjxfzHrnLh9yPokc29_YHxeee38QwHtMCRw7jZvHpuPj6C8h-S4E |
| linkProvider | Directory of Open Access Journals |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1R3JbhMx1CoFBBf2ZaDAgIALjDrj2ewDQmGpUjVEPQSpN8v2eJKINAmZpCic-A0-gp_iS3jPs1RDRW49cPU8L_K81W8j5DlNOFM8l17uSx-LakuPZ0x6VObM1xr4prIl83tpv8-OjvjhFvlV58JgWGXNEy2jzmYa38h3aZSC6Q0KcPR2_tXDrlHoXa1baJRocWDW38BkK97sf4D_-4LSvY-D912v6irgabANlp7K0ZdIVQw2ZSC5SQzTCQ20nyqTRxlTiW8Yz3QQ5lIrFSrYV8bKKO5rmsgQlr1ALkZYWAwjBelh86SDTrMo4FVqjh-y3QLEI6awUYzaA_LxeEv82S4BINRGGIN5VsE9G6fZOGv_KmxqheHe9f_sGm-Qa5XW7XZKMrlJtsz0Frlc9uFc3ybp54VNS3aPzRKIYjLWLoa-zZZrzCZzQa93O5PvIzM-NovfP34WbuXWukMG53Hou2R7Opua-8SlYSTDVCoZmQgjFCTlipk0Q0-xH2exQ4L6PwtdVVvHph8TYb3-IRMlbgjADWFxQ3CHvGrmzMtaIxuh3yH6NJBYJ9wOzBZDUbEdEaiMxTkYyVmcwrliJVMd5CrCfGaVGemQZ4B8rTW6nZ7AMdD1UX9MTgKH7NS4JCoOV4hTRHLI0-Yz8CZ0OMmpma0sjG2FxWCJeyUqN1uFMDtkIcxOW0jeOkv7y3Q8svXPU5RKDGa-rsnh9Fib7utlSTKtHYaruYCh4UoURoRoQPwDsBr6MkbAKIl55D_YfC9PyJXu4FNP9Pb7Bw_JVYpcIKCg9-yQ7eViZR6RS_pkOS4Wjy0bcYk4Z3r7AwS1sRs |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1R3LbtNAcFVSqLjwLgQKGARcwIq9fu0eEAqUqFFDlEOR2tNqd71OItIkxElROPEbfAq_w5cw41dlKnLrget6dj1az9PzIuQFDTlTPJF24kgHm2pLm8dM2lQmzNEa5KbKWub3on6fHR_zwRb5VdbCYFplKRMzQR3PNP4jb1E_AtcbDGC_lRRpEYP9zrv5VxsnSGGktRynkZPIoVl_A_ctfdvdh2_9ktLOx6MPB3YxYcDW4CcsbZVgXJGqAPxLV3ITGqZD6monUibxY6ZCxzAea9dLpFbKU4CDDJRR3NE0lB4ce4Vsg0Xu0wbZHnQ_DU6qHzwYQvNdXhTqOB5rpaAssaCNYg4fMJPNa8owmxkAKm6EGZkXzd2LWZtV6PavNqeZauzc_I8v9Ra5UdjjVjtnoNtky0zvkGv5hM71XRJ9XmQFy9apWQK7TMbawqS42XKNdWYWWPxWe_J9ZManZvH7x8_UKgJe98jRZSC9SxrT2dQ8IBb1fOlFUknf-Ji7IClXzEQxxpCdIA6axC2_udBFH3YcBzIRWT6Ax0ROJwLoRGR0IniTvK72zPMuJBuh3yMpVZDYQTxbmC2GohBIwlUxCxJwn-MgArwCJSPtJsrHSmcVG9kkz4EQa2cctHsC18ALQMsyPHObZK-kK1HIvlScE1WTPKseg9TCUJScmtkqg8mGZDE44n5O1tWrPNjtMQ92RzWCr-FSfzIdj7LO6BHqKwY735SscY7Wpvt6lbNP7Q3D1VzA0nAlUiM8dC3-AVgsfRkjoB8G3Hcebr6Xp2QH2Ez0uv3DR-Q6RYHgUjCI9khjuViZx-SqPluO08WTQqZYRFwyw_0BJ_-7ZA |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Urinary+metabolic+phenotyping+for+Alzheimer%E2%80%99s+disease&rft.jtitle=Scientific+reports&rft.au=Natalja+Kurbatova&rft.au=Manik+Garg&rft.au=Luke+Whiley&rft.au=Elena+Chekmeneva&rft.date=2020-12-10&rft.pub=Nature+Portfolio&rft.eissn=2045-2322&rft.volume=10&rft.issue=1&rft.spage=1&rft.epage=17&rft_id=info:doi/10.1038%2Fs41598-020-78031-9&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_1bd85f619d574055ba7c1fb49956bdea |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2045-2322&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2045-2322&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2045-2322&client=summon |