BDNF DNA methylation changes as a biomarker of psychiatric disorders: literature review and open access database analysis

Brain-derived neurotrophic factor (BDNF) plays an important role in nervous system development and function and it is well established that BDNF is involved in the pathogenesis of a wide range of psychiatric disorders. Recently, numerous studies have associated the DNA methylation level of BDNF prom...

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Vydané v:Behavioral and brain functions Ročník 12; číslo 1; s. 17
Hlavní autori: Zheleznyakova, Galina Y., Cao, Hao, Schiöth, Helgi B.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: London BioMed Central 06.06.2016
Springer Nature B.V
Predmet:
Animals
BDNF
Behavioral neurogenetics and epigenetics
Behavioral Therapy
Biomarkers
Biomarkers - blood
Biomedical and Life Sciences
Biomedicine
Brain - metabolism
Brain-Derived Neurotrophic Factor - genetics
Brain-Derived Neurotrophic Factor - metabolism
Databases, Genetic
DNA Methylation
Humans
Mental Disorders - genetics
Neurology
Neurosciences
Phenotype
Promoter Regions, Genetic
Psychiatric disorders
Psychiatry
Review
DNA methylation
Biomarkers
Psychiatric disorders
BDNF
ISSN:1744-9081, 1744-9081
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Popis
Shrnutí:Brain-derived neurotrophic factor (BDNF) plays an important role in nervous system development and function and it is well established that BDNF is involved in the pathogenesis of a wide range of psychiatric disorders. Recently, numerous studies have associated the DNA methylation level of BDNF promoters with certain psychiatric phenotypes. In this review, we summarize data from current literature as well as from our own analysis with respect to the correlation of BDNF methylation changes with psychiatric disorders and address questions about whether DNA methylation related to the BDNF can be useful as biomarker for specific neuropsychiatric disorders.
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ISSN:1744-9081
1744-9081
DOI:10.1186/s12993-016-0101-4