Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases

The term sarcopenia refers to the loss of muscle mass that occurs with ageing. On the basis of study results showing that muscle mass is only moderately related to functional outcomes, international working groups have proposed that loss of muscle strength or physical function should also be include...

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Veröffentlicht in:The lancet. Diabetes & endocrinology Jg. 2; H. 10; S. 819
Hauptverfasser: Kalyani, Rita Rastogi, Corriere, Mark, Ferrucci, Luigi
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England 01.10.2014
Schlagworte:
Diabetes Complications
Endocrine System Diseases - complications
Humans
Male
Obesity - complications
Sarcopenia - complications
ISSN:2213-8595, 2213-8595
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Zusammenfassung:The term sarcopenia refers to the loss of muscle mass that occurs with ageing. On the basis of study results showing that muscle mass is only moderately related to functional outcomes, international working groups have proposed that loss of muscle strength or physical function should also be included in the definition. Irrespective of how sarcopenia is defined, both low muscle mass and poor muscle strength are clearly highly prevalent and important risk factors for disability and potentially mortality in individuals as they age. Many chronic diseases, in addition to ageing, could also accelerate decrease of muscle mass and strength, and this effect could be a main underlying mechanism by which chronic diseases cause physical disability. In this Review, we address both age-related and disease-related muscle loss, with a focus on diabetes and obesity but including other disease states, and potential common mechanisms and treatments. Development of treatments for age-related and disease-related muscle loss might improve active life expectancy in older people, and lead to substantial health-care savings and improved quality of life.
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ObjectType-Review-3
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ISSN:2213-8595
2213-8595
DOI:10.1016/S2213-8587(14)70034-8