Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

Helen Hobbs and colleagues report an association between coding variation in PNPLA3 and susceptibility to nonalcoholic fatty liver disease. The associated alleles vary in frequency among Hispanics, African Americans and European Americans and contribute to differences in disease prevalence among the...

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Veröffentlicht in:	Nature genetics Jg. 40; H. 12; S. 1461 - 1465
Hauptverfasser:	Romeo, Stefano, Kozlitina, Julia, Xing, Chao, Pertsemlidis, Alexander, Cox, David, Pennacchio, Len A, Boerwinkle, Eric, Cohen, Jonathan C, Hobbs, Helen H
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Nature Publishing Group US 01.12.2008 Nature Publishing Group
Schlagworte:	African Americans Agriculture Animal Genetics and Genomics Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Diet Fatty liver Fatty Liver - epidemiology Fatty Liver - ethnology Fatty Liver - genetics Female Fundamental and applied biological sciences. Psychology Gastroenterology. Liver. Pancreas. Abdomen Gene Function Genetic aspects Genetic diversity Genetic Predisposition to Disease Genetic susceptibility Genetic variance Genetic Variation Genetics of eukaryotes. Biological and molecular evolution Hispanic people Human Genetics Humans letter Lipase - genetics Liver diseases Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Membrane Proteins - genetics Other diseases. Semiology Plasma Risk factors Single nucleotide polymorphisms United States Digestive diseases Hepatic disease Genetic variability Non alcoholic steatohepatitis Genetic variant
ISSN:	1061-4036, 1546-1718, 1546-1718
Online-Zugang:	Volltext
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