Maternal, fetal and perinatal alterations associated with obesity, overweight and gestational diabetes: an observational cohort study (PREOBE)

Background Maternal overweight, obesity, and gestational diabetes (GD) have been negatively associated with offspring development. Further knowledge regarding metabolic and nutritional alterations in these mother and their offspring are warranted. Methods In an observational cohort study we included...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	BMC public health Ročník 16; číslo 1; s. 207 - 12
Hlavní autoři:	Berglund, Staffan K., García-Valdés, Luz, Torres-Espinola, Francisco J, Segura, Mª Teresa, Martínez-Zaldívar, Cristina, Aguilar, María J., Agil, Ahmad, Lorente, Jose A., Florido, Jesús, Padilla, Carmen, Altmäe, Signe, Marcos, Acensión, López-Sabater, M. Carmen, Campoy, Cristina
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London BioMed Central 01.03.2016 BioMed Central Ltd Springer Nature B.V BMC
Témata:	Adult Age Bioethics Biomarkers Biomarkers - blood Biostatistics Birth weight Birth Weight - physiology Body mass index Body weight C-reactive protein Carbohydrate metabolism Childrens health Cohort analysis Cohort Studies Cord blood Cortisol Data collection Diabetes Diabetes in pregnancy Diabetes mellitus Diabetes, Gestational - physiopathology Diabetis en l'embaràs Early programming Embaràs Energy balance-related behaviors Environmental Health Epidemiology Erythrocyte sedimentation rate Erythrocytes Fatty acids Female Ferritin Fetal Macrosomia - epidemiology Fetal nutrition Fetuses Folate Folic acid Gestational diabetes Glucose Glucose metabolism Health aspects Hemoglobin Hospitals Humans Immunology Infant Infants Insulin Iron status Laboratories Male Maternal obesity Maternal overweight Maternal-fetal exchange Medicine Medicine & Public Health Metabolic diseases Metabolism Metabolisme dels glúcids Microbiota Mothers Obesitat Obesity Obesity - physiopathology Observational studies Offspring Overweight Overweight - physiopathology Physiological aspects Placenta Pregnancy Pregnancy, Complications of Prenatal Exposure Delayed Effects - epidemiology Prenatal Nutritional Physiological Phenomena - physiology Proteins Public Health Research Article Risk factors Spain - epidemiology Studies Transferrin Transferrins Uric acid Vaccine Vitamin B12 Weight Gain - physiology Womens health Young Adult Spain Pregnancy Glucose metabolism Offspring Early programming Iron status Maternal obesity Fetal nutrition Gestational diabetes Maternal overweight Vitamin B12 Folate
ISSN:	1471-2458, 1471-2458
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Popis
Shrnutí:	Background Maternal overweight, obesity, and gestational diabetes (GD) have been negatively associated with offspring development. Further knowledge regarding metabolic and nutritional alterations in these mother and their offspring are warranted. Methods In an observational cohort study we included 331 pregnant women from Granada, Spain. The mothers were categorized into four groups according to BMI and their GD status; overweight (n:56), obese (n:64), GD (n:79), and healthy normal weight controls (n:132). We assessed maternal growth and nutritional biomarkers at 24 weeks ( n = 269), 34 weeks ( n = 310) and at delivery ( n = 310) and the perinatal characteristics including cord blood biomarkers. Results Obese and GD mothers had significantly lower weight gain during pregnancy and infant birth weight, waist circumference, and placental weight were higher in the obese group, including a significantly increased prevalence of macrosomia. Except for differences in markers of glucose metabolism (glucose, HbA1c, insulin and uric acid) we found at some measures that overweight and/or obese mothers had lower levels of transferrin saturation, hemoglobin, Vitamin B12 and folate and higher levels of C-reactive protein, erythrocyte sedimentation rate, ferritin, and cortisol. GD mothers had similar differences in hemoglobin and C-reactive protein but higher levels of folate. The latter was seen also in cord blood. Conclusions We identified several metabolic alterations in overweight, obese and GD mothers compared to controls. Together with the observed differences in infant anthropometrics, these may be important biomarkers in future research regarding the programming of health and disease in children. Trial registration The trial was registered at clinicaltrials.gov, identifier ( NCT01634464 ).
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23 ObjectType-Undefined-3
ISSN:	1471-2458 1471-2458
DOI:	10.1186/s12889-016-2809-3