Standard method for detecting upper respiratory carriage of Streptococcus pneumoniae: Updated recommendations from the World Health Organization Pneumococcal Carriage Working Group

•We present updated recommendations from a World Health Organization working group.•These are a core set of standard methods for pneumococcal carriage studies.•Methods for the collection, transport and storage of nasopharyngeal samples are outlined.•Methods for identification and serotyping of pneum...

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Veröffentlicht in:Vaccine Jg. 32; H. 1; S. 165 - 179
Hauptverfasser: Satzke, Catherine, Turner, Paul, Virolainen-Julkunen, Anni, Adrian, Peter V., Antonio, Martin, Hare, Kim M., Henao-Restrepo, Ana Maria, Leach, Amanda J., Klugman, Keith P., Porter, Barbara D., Sá-Leão, Raquel, Scott, J. Anthony, Nohynek, Hanna, O’Brien, Katherine L.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Netherlands Elsevier Ltd 17.12.2013
Elsevier
Schlagworte:
Allergy and Immunology
Bacteriological Techniques - standards
Carriage
Carrier State - diagnosis
Carrier State - microbiology
Colonization
epidemiological studies
Humans
Life Sciences
Nasopharynx
Nasopharynx - microbiology
Pneumococcal Infections - diagnosis
Pneumococcal Infections - microbiology
Pneumococcus
Sensitivity and Specificity
Serotyping
Specimen Handling
Streptococcus pneumoniae
Streptococcus pneumoniae - classification
Streptococcus pneumoniae - isolation & purification
vaccines
World Health Organization
Nasopharynx
Pneumococcus
Colonization
Carriage
ISSN:0264-410X, 1873-2518, 1873-2518
Online-Zugang:Volltext
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Zusammenfassung:•We present updated recommendations from a World Health Organization working group.•These are a core set of standard methods for pneumococcal carriage studies.•Methods for the collection, transport and storage of nasopharyngeal samples are outlined.•Methods for identification and serotyping of pneumococci are described.•The epidemiological rationale for pneumococcal carriage studies is described. In 2003 the World Health Organization (WHO) convened a working group and published a set of standard methods for studies measuring nasopharyngeal carriage of Streptococcus pneumoniae (the pneumococcus). The working group recently reconvened under the auspices of the WHO and updated the consensus standard methods. These methods describe the collection, transport and storage of nasopharyngeal samples, as well as provide recommendations for the identification and serotyping of pneumococci using culture and non-culture based approaches. We outline the consensus position of the working group, the evidence supporting this position, areas worthy of future research, and the epidemiological role of carriage studies. Adherence to these methods will reduce variability in the conduct of pneumococcal carriage studies undertaken in the context of pneumococcal vaccine trials, implementation studies, and epidemiology studies more generally so variability in methodology does not confound the interpretation of study findings.
Bibliographie:http://dx.doi.org/10.1016/j.vaccine.2013.08.062
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ISSN:0264-410X
1873-2518
1873-2518
DOI:10.1016/j.vaccine.2013.08.062