Distinctive transcriptome alterations of prefrontal pyramidal neurons in schizophrenia and schizoaffective disorder

Schizophrenia is associated with alterations in working memory that reflect dysfunction of dorsolateral prefrontal cortex (DLPFC) circuitry. Working memory depends on the activity of excitatory pyramidal cells in DLPFC layer 3 and, to a lesser extent, in layer 5. Although many studies have profiled...

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Veröffentlicht in:	Molecular psychiatry Jg. 20; H. 11; S. 1397 - 1405
Hauptverfasser:	Arion, D, Corradi, J P, Tang, S, Datta, D, Boothe, F, He, A, Cacace, A M, Zaczek, R, Albright, C F, Tseng, G, Lewis, D A
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 01.11.2015 Nature Publishing Group
Schlagworte:	38/61 692/699/476/1799 Adult Analysis Analysis of Variance Animals Antipsychotic Agents - pharmacology Behavioral Sciences Biological Psychology Diagnosis DNA microarrays Female Gene expression Gene Expression Profiling Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Genetic aspects Humans Laser Capture Microdissection Lasers Macaca fascicularis Male Medicine Medicine & Public Health Memory Mental disorders Middle Aged Mitochondria Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Neurons Neurosciences Oligonucleotide Array Sequence Analysis original-article Pharmacotherapy Phenotypes Physiological aspects Prefrontal cortex Prefrontal Cortex - drug effects Prefrontal Cortex - pathology Proteasomes Psychiatry Psychotic Disorders - pathology Pyramidal cells Pyramidal Cells - metabolism Risk factors RNA, Messenger - metabolism Schizoaffective disorder Schizoaffective disorders Schizophrenia Schizophrenia - pathology Short term memory Signal Transduction - drug effects Signal Transduction - physiology Substantia grisea Transcription Transcriptome - physiology Ubiquitin Ubiquitin - genetics Ubiquitin - metabolism United States United States > US Pittsburgh Pennsylvania
ISSN:	1359-4184, 1476-5578, 1476-5578
Online-Zugang:	Volltext
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