TREM-1 orchestrates angiotensin II–induced monocyte trafficking and promotes experimental abdominal aortic aneurysm

The triggering receptor expressed on myeloid cells 1 (TREM-1) drives inflammatory responses in several cardiovascular diseases but its role in abdominal aortic aneurysm (AAA) remains unknown. Our objective was to explore the role of TREM-1 in a mouse model of angiotensin II-induced (AngII-induced) A...

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Veröffentlicht in:	The Journal of clinical investigation Jg. 131; H. 2; S. 1 - 14
Hauptverfasser:	Vandestienne, Marie, Zhang, Yujiao, Santos-Zas, Icia, Al-Rifai, Rida, Joffre, Jeremie, Giraud, Andreas, Laurans, Ludivine, Esposito, Bruno, Pinet, Florence, Bruneval, Patrick, Raffort, Juliette, Lareyre, Fabien, Vilar, Jose, Boufenzer, Amir, Guyonnet, Lea, Guerin, Coralie, Clauser, Eric, Silvestre, Jean-Sébastien, Lang, Sylvie, Soulat-Dufour, Laurie, Tedgui, Alain, Mallat, Ziad, Taleb, Soraya, Boissonnas, Alexandre, Derive, Marc, Chinetti, Giulia, Ait-Oufella, Hafid
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States American Society for Clinical Investigation 19.01.2021
Schlagworte:	Abdomen Abdominal aneurysm Adapter proteins Aneurysms Angiotensin Angiotensin II Angiotensin II - adverse effects Angiotensin II - pharmacology Animals Aorta Aortic Aneurysm, Abdominal - chemically induced Aortic Aneurysm, Abdominal - genetics Aortic Aneurysm, Abdominal - metabolism Aortic Aneurysm, Abdominal - pathology Aortic aneurysms Apolipoprotein E Atherosclerosis Biomedical research Blood pressure Cardiovascular diseases Cardiovascular system Cell activation Cell Movement - drug effects Cell Movement - genetics Chemokines Coronary vessels Cytokines Development and progression Flow cytometry Gelatinase A Gelatinase B Gene Deletion Gene expression Health aspects Human health and pathology Humans Inflammation Interleukin-1beta - genetics Interleukin-1beta - metabolism L-selectin Life Sciences Macrophages Matrix Metalloproteinase 2 - genetics Matrix Metalloproteinase 2 - metabolism Membrane proteins Mice Mice, Knockout, ApoE Monocytes Monocytes - metabolism Monocytes - pathology Myeloid cells Neutrophils Pathophysiology Peptides Physiological aspects Spleen Therapeutic targets Triggering Receptor Expressed on Myeloid Cells-1 - genetics Triggering Receptor Expressed on Myeloid Cells-1 - metabolism Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism France Innate immunity Monocytes Inflammation Cell migration/adhesion Vascular Biology
ISSN:	0021-9738, 1558-8238, 1558-8238
Online-Zugang:	Volltext
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