Recombination-restarted replication makes inverted chromosome fusions at inverted repeats

A new mechanism of chromosomal rearrangement is identified through the observation that broken or collapsed DNA replication forks restarted by homologous recombination have a high propensity for U-turns at short inverted repeats; the error-prone nature of this mechanism is suggested to contribute to...

Full description

Saved in:

Bibliographic Details
Published in:	Nature (London) Vol. 493; no. 7431; pp. 246 - 249
Main Authors:	Mizuno, Ken’Ichi, Miyabe, Izumi, Schalbetter, Stephanie A., Carr, Antony M., Murray, Johanne M.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 10.01.2013 Nature Publishing Group
Subjects:	631/337/1427/2190 631/337/1427/2567 631/337/149 631/337/151/2356 631/80/304 Arrests Cancer Chromosome Inversion - genetics Deoxyribonucleic acid DNA DNA Copy Number Variations - genetics DNA replication DNA Replication - genetics DNA, Fungal - genetics DNA, Ribosomal - genetics Environmental factors Gene amplification Genes, Fungal - genetics Genetic recombination Genetics Genomes Humanities and Social Sciences Inverted Repeat Sequences - genetics letter Models, Genetic multidisciplinary Neoplasms - genetics Physiological aspects Recombination, Genetic - genetics Ribosomal DNA Saccharomyces cerevisiae - genetics Schizosaccharomyces - genetics Schizosaccharomyces pombe Science Yeasts United Kingdom
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!