Recombination-restarted replication makes inverted chromosome fusions at inverted repeats

A new mechanism of chromosomal rearrangement is identified through the observation that broken or collapsed DNA replication forks restarted by homologous recombination have a high propensity for U-turns at short inverted repeats; the error-prone nature of this mechanism is suggested to contribute to...

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Veröffentlicht in:	Nature (London) Jg. 493; H. 7431; S. 246 - 249
Hauptverfasser:	Mizuno, Ken’Ichi, Miyabe, Izumi, Schalbetter, Stephanie A., Carr, Antony M., Murray, Johanne M.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 10.01.2013 Nature Publishing Group
Schlagworte:	631/337/1427/2190 631/337/1427/2567 631/337/149 631/337/151/2356 631/80/304 Arrests Cancer Chromosome Inversion - genetics Deoxyribonucleic acid DNA DNA Copy Number Variations - genetics DNA replication DNA Replication - genetics DNA, Fungal - genetics DNA, Ribosomal - genetics Environmental factors Gene amplification Genes, Fungal - genetics Genetic recombination Genetics Genomes Humanities and Social Sciences Inverted Repeat Sequences - genetics letter Models, Genetic multidisciplinary Neoplasms - genetics Physiological aspects Recombination, Genetic - genetics Ribosomal DNA Saccharomyces cerevisiae - genetics Schizosaccharomyces - genetics Schizosaccharomyces pombe Science Yeasts United Kingdom
ISSN:	0028-0836, 1476-4687, 1476-4687
Online-Zugang:	Volltext
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