The Immortalized UROtsa Cell Line as a Potential Cell Culture Model of Human Urothelium

The UROtsa cell line was isolated from a primary culture of normal human urothelium through immortalization with a construct containing the SV40 large T antigen. It proliferates in serum-containing growth medium as a cell monolayer with little evidence of uroepithelial differentiation. The working h...

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Bibliographic Details
Published in:	Environmental health perspectives Vol. 109; no. 8; pp. 801 - 808
Main Authors:	Rossi, Michael R., John R. W. Masters, Park, Seongmi, Todd, John H., Garrett, Scott H., Sens, Mary Ann, Somji, Seema, Nath, Joginder, Sens, Donald A.
Format:	Journal Article
Language:	English
Published:	United States National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare 01.08.2001 National Institute of Environmental Health Sciences
Subjects:	Cell culture techniques Cell Culture Techniques - methods Cell Division Cell growth Cell Line Cell lines Cell Transformation, Viral Culture Media Cultured cells Dendritic cells Epithelial cells Gene Expression Heat-Shock Proteins - genetics Humans Kidney Tubules, Proximal Messenger RNA Metallothionein - biosynthesis Models, Biological Protein Isoforms - biosynthesis Protein Isoforms - genetics RNA RNA, Antisense - genetics RNA, Messenger - biosynthesis Transfection - methods Ureter - cytology Urinary bladder Urothelium Urothelium - cytology
ISSN:	0091-6765, 1552-9924
Online Access:	Get full text
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