PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer

The PI3K/AKT/mTOR (PAM) signaling pathway is a highly conserved signal transduction network in eukaryotic cells that promotes cell survival, cell growth, and cell cycle progression. Growth factor signalling to transcription factors in the PAM axis is highly regulated by multiple cross-interactions w...

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Bibliographic Details
Published in:	Molecular cancer Vol. 22; no. 1; pp. 138 - 37
Main Authors:	Glaviano, Antonino, Foo, Aaron S. C., Lam, Hiu Y., Yap, Kenneth C. H., Jacot, William, Jones, Robert H., Eng, Huiyan, Nair, Madhumathy G., Makvandi, Pooyan, Geoerger, Birgit, Kulke, Matthew H., Baird, Richard D., Prabhu, Jyothi S., Carbone, Daniela, Pecoraro, Camilla, Teh, Daniel B. L., Sethi, Gautam, Cavalieri, Vincenzo, Lin, Kevin H., Javidi-Sharifi, Nathalie R., Toska, Eneda, Davids, Matthew S., Brown, Jennifer R., Diana, Patrizia, Stebbing, Justin, Fruman, David A., Kumar, Alan P.
Format:	Journal Article
Language:	English
Published:	London BioMed Central 18.08.2023 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	1-Phosphatidylinositol 3-kinase AKT inhibitors AKT protein Allosteric mTOR inhibitors Antineoplastic drugs Biochemistry, Molecular Biology Biomedical and Life Sciences Biomedicine Bone cancer Brain cancer Breast cancer Cancer Cancer Research Care and treatment Cell cycle Cell growth Cell survival Cellular signal transduction Cervical cancer Clinical trials Development and progression Disease resistance Dual PI3K/mTOR inhibitors Estrogens Gallbladder cancer Gastric cancer Genomics Growth factors Health aspects Humans Hyperactivity Immunotherapy Isoform-specific PI3K inhibitors Kidney cancer Kinases Leukemia Life Sciences Lung cancer Medical prognosis Melanoma Metastasis Mutation Neoplasms Neoplasms - drug therapy Neoplasms - genetics Oncology Ovarian cancer Pan PI3K inhibitors Pharmaceutical sciences Pharmacology Phosphatidylinositol 3-Kinases PI3K/AKT/mTORC pathway Prostate cancer Proto-Oncogene Proteins c-akt PTEN protein Review Sarcoma Signal Transduction Thyroid cancer TOR protein TOR Serine-Threonine Kinases Transcription factors Treatment resistance Tumors PDK1 inhibitors AKT inhibitors Pan PI3K inhibitors Allosteric mTOR inhibitors Bi-steric mTOR inhibitors PI3K/AKT/mTORC pathway Isoform-specific PI3K inhibitors Dual PI3K/mTOR inhibitors ATP-competitive mTOR inhibitors Cancer
ISSN:	1476-4598, 1476-4598
Online Access:	Get full text
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