Recent advances in exosome-mediated nucleic acid delivery for cancer therapy

Cancer is a leading public health problem worldwide. Its treatment remains a daunting challenge, although significant progress has been made in existing treatments in recent years. A large concern is the poor therapeutic effect due to lack of specificity and low bioavailability. Gene therapy has rec...

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Veröffentlicht in:Journal of nanobiotechnology Jg. 20; H. 1; S. 279 - 29
Hauptverfasser: Zhang, Ying, Liu, Qiqi, Zhang, Xinmeng, Huang, Haoqiang, Tang, Shiqi, Chai, Yujuan, Xu, Zhourui, Li, Meirong, Chen, Xin, Liu, Jia, Yang, Chengbin
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London BioMed Central 14.06.2022
BioMed Central Ltd
Springer Nature B.V
BMC
Schlagworte:
Acids
Analysis
B cells
Bioavailability
Biocompatibility
Biosynthesis
Biotechnology
Cancer
Cancer therapies
Cancer treatment
Care and treatment
Chemistry
Chemistry and Materials Science
Chemotherapy
Circular RNA
Clinical trials
Delivery
Deoxyribonucleic acid
DNA
Dosage and administration
Drug development
Drugs
Efficiency
Exosome
Exosomes
Extracellular vesicles
Gene expression
Gene therapy
Genetic engineering
Immunogenicity
Lipids
MicroRNA
MicroRNAs
miRNA
Molecular Medicine
mRNA
Nanotechnology
Nucleic acid drug
Nucleic acids
Proteins
Public health
Review
Ribonucleic acid
RNA
siRNA
Toxicity
China
Delivery
Gene therapy
Exosome
Cancer treatment
Nucleic acid drug
ISSN:1477-3155, 1477-3155
Online-Zugang:Volltext
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Abstract Cancer is a leading public health problem worldwide. Its treatment remains a daunting challenge, although significant progress has been made in existing treatments in recent years. A large concern is the poor therapeutic effect due to lack of specificity and low bioavailability. Gene therapy has recently emerged as a powerful tool for cancer therapy. However, delivery methods limit its therapeutic effects. Exosomes, a subset of extracellular vesicles secreted by most cells, have the characteristics of good biocompatibility, low toxicity and immunogenicity, and great designability. In the past decades, as therapeutic carriers and diagnostic markers, they have caught extensive attention. This review introduced the characteristics of exosomes, and focused on their applications as delivery carriers in DNA, messenger RNA (mRNA), microRNA (miRNA), small interfering RNA (siRNA), circular RNA (circRNA) and other nucleic acids. Meanwhile, their application in cancer therapy and exosome-based clinical trials were presented and discussed. Through systematic summarization and analysis, the recent advances and current challenges of exosome-mediated nucleic acid delivery for cancer therapy are introduced, which will provide a theoretical basis for the development of nucleic acid drugs. Graphical Abstract
AbstractList Cancer is a leading public health problem worldwide. Its treatment remains a daunting challenge, although significant progress has been made in existing treatments in recent years. A large concern is the poor therapeutic effect due to lack of specificity and low bioavailability. Gene therapy has recently emerged as a powerful tool for cancer therapy. However, delivery methods limit its therapeutic effects. Exosomes, a subset of extracellular vesicles secreted by most cells, have the characteristics of good biocompatibility, low toxicity and immunogenicity, and great designability. In the past decades, as therapeutic carriers and diagnostic markers, they have caught extensive attention. This review introduced the characteristics of exosomes, and focused on their applications as delivery carriers in DNA, messenger RNA (mRNA), microRNA (miRNA), small interfering RNA (siRNA), circular RNA (circRNA) and other nucleic acids. Meanwhile, their application in cancer therapy and exosome-based clinical trials were presented and discussed. Through systematic summarization and analysis, the recent advances and current challenges of exosome-mediated nucleic acid delivery for cancer therapy are introduced, which will provide a theoretical basis for the development of nucleic acid drugs. Graphical Keywords: Gene therapy, Exosome, Nucleic acid drug, Delivery, Cancer treatment
Cancer is a leading public health problem worldwide. Its treatment remains a daunting challenge, although significant progress has been made in existing treatments in recent years. A large concern is the poor therapeutic effect due to lack of specificity and low bioavailability. Gene therapy has recently emerged as a powerful tool for cancer therapy. However, delivery methods limit its therapeutic effects. Exosomes, a subset of extracellular vesicles secreted by most cells, have the characteristics of good biocompatibility, low toxicity and immunogenicity, and great designability. In the past decades, as therapeutic carriers and diagnostic markers, they have caught extensive attention. This review introduced the characteristics of exosomes, and focused on their applications as delivery carriers in DNA, messenger RNA (mRNA), microRNA (miRNA), small interfering RNA (siRNA), circular RNA (circRNA) and other nucleic acids. Meanwhile, their application in cancer therapy and exosome-based clinical trials were presented and discussed. Through systematic summarization and analysis, the recent advances and current challenges of exosome-mediated nucleic acid delivery for cancer therapy are introduced, which will provide a theoretical basis for the development of nucleic acid drugs.
Cancer is a leading public health problem worldwide. Its treatment remains a daunting challenge, although significant progress has been made in existing treatments in recent years. A large concern is the poor therapeutic effect due to lack of specificity and low bioavailability. Gene therapy has recently emerged as a powerful tool for cancer therapy. However, delivery methods limit its therapeutic effects. Exosomes, a subset of extracellular vesicles secreted by most cells, have the characteristics of good biocompatibility, low toxicity and immunogenicity, and great designability. In the past decades, as therapeutic carriers and diagnostic markers, they have caught extensive attention. This review introduced the characteristics of exosomes, and focused on their applications as delivery carriers in DNA, messenger RNA (mRNA), microRNA (miRNA), small interfering RNA (siRNA), circular RNA (circRNA) and other nucleic acids. Meanwhile, their application in cancer therapy and exosome-based clinical trials were presented and discussed. Through systematic summarization and analysis, the recent advances and current challenges of exosome-mediated nucleic acid delivery for cancer therapy are introduced, which will provide a theoretical basis for the development of nucleic acid drugs. Graphical Abstract
Cancer is a leading public health problem worldwide. Its treatment remains a daunting challenge, although significant progress has been made in existing treatments in recent years. A large concern is the poor therapeutic effect due to lack of specificity and low bioavailability. Gene therapy has recently emerged as a powerful tool for cancer therapy. However, delivery methods limit its therapeutic effects. Exosomes, a subset of extracellular vesicles secreted by most cells, have the characteristics of good biocompatibility, low toxicity and immunogenicity, and great designability. In the past decades, as therapeutic carriers and diagnostic markers, they have caught extensive attention. This review introduced the characteristics of exosomes, and focused on their applications as delivery carriers in DNA, messenger RNA (mRNA), microRNA (miRNA), small interfering RNA (siRNA), circular RNA (circRNA) and other nucleic acids. Meanwhile, their application in cancer therapy and exosome-based clinical trials were presented and discussed. Through systematic summarization and analysis, the recent advances and current challenges of exosome-mediated nucleic acid delivery for cancer therapy are introduced, which will provide a theoretical basis for the development of nucleic acid drugs.Cancer is a leading public health problem worldwide. Its treatment remains a daunting challenge, although significant progress has been made in existing treatments in recent years. A large concern is the poor therapeutic effect due to lack of specificity and low bioavailability. Gene therapy has recently emerged as a powerful tool for cancer therapy. However, delivery methods limit its therapeutic effects. Exosomes, a subset of extracellular vesicles secreted by most cells, have the characteristics of good biocompatibility, low toxicity and immunogenicity, and great designability. In the past decades, as therapeutic carriers and diagnostic markers, they have caught extensive attention. This review introduced the characteristics of exosomes, and focused on their applications as delivery carriers in DNA, messenger RNA (mRNA), microRNA (miRNA), small interfering RNA (siRNA), circular RNA (circRNA) and other nucleic acids. Meanwhile, their application in cancer therapy and exosome-based clinical trials were presented and discussed. Through systematic summarization and analysis, the recent advances and current challenges of exosome-mediated nucleic acid delivery for cancer therapy are introduced, which will provide a theoretical basis for the development of nucleic acid drugs.
Cancer is a leading public health problem worldwide. Its treatment remains a daunting challenge, although significant progress has been made in existing treatments in recent years. A large concern is the poor therapeutic effect due to lack of specificity and low bioavailability. Gene therapy has recently emerged as a powerful tool for cancer therapy. However, delivery methods limit its therapeutic effects. Exosomes, a subset of extracellular vesicles secreted by most cells, have the characteristics of good biocompatibility, low toxicity and immunogenicity, and great designability. In the past decades, as therapeutic carriers and diagnostic markers, they have caught extensive attention. This review introduced the characteristics of exosomes, and focused on their applications as delivery carriers in DNA, messenger RNA (mRNA), microRNA (miRNA), small interfering RNA (siRNA), circular RNA (circRNA) and other nucleic acids. Meanwhile, their application in cancer therapy and exosome-based clinical trials were presented and discussed. Through systematic summarization and analysis, the recent advances and current challenges of exosome-mediated nucleic acid delivery for cancer therapy are introduced, which will provide a theoretical basis for the development of nucleic acid drugs.
Abstract Cancer is a leading public health problem worldwide. Its treatment remains a daunting challenge, although significant progress has been made in existing treatments in recent years. A large concern is the poor therapeutic effect due to lack of specificity and low bioavailability. Gene therapy has recently emerged as a powerful tool for cancer therapy. However, delivery methods limit its therapeutic effects. Exosomes, a subset of extracellular vesicles secreted by most cells, have the characteristics of good biocompatibility, low toxicity and immunogenicity, and great designability. In the past decades, as therapeutic carriers and diagnostic markers, they have caught extensive attention. This review introduced the characteristics of exosomes, and focused on their applications as delivery carriers in DNA, messenger RNA (mRNA), microRNA (miRNA), small interfering RNA (siRNA), circular RNA (circRNA) and other nucleic acids. Meanwhile, their application in cancer therapy and exosome-based clinical trials were presented and discussed. Through systematic summarization and analysis, the recent advances and current challenges of exosome-mediated nucleic acid delivery for cancer therapy are introduced, which will provide a theoretical basis for the development of nucleic acid drugs. Graphical Abstract
ArticleNumber 279
Audience Academic
Author Zhang, Xinmeng
Chen, Xin
Xu, Zhourui
Li, Meirong
Yang, Chengbin
Liu, Qiqi
Zhang, Ying
Chai, Yujuan
Liu, Jia
Tang, Shiqi
Huang, Haoqiang
Author_xml – sequence: 1
  givenname: Ying
  surname: Zhang
  fullname: Zhang, Ying
  organization: Central Laboratory of Longgang District People’s Hospital of Shenzhen & The Second Affiliated Hospital, The Chinese University of Hong Kong, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University
– sequence: 2
  givenname: Qiqi
  surname: Liu
  fullname: Liu, Qiqi
  organization: Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University
– sequence: 3
  givenname: Xinmeng
  surname: Zhang
  fullname: Zhang, Xinmeng
  organization: Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University
– sequence: 4
  givenname: Haoqiang
  surname: Huang
  fullname: Huang, Haoqiang
  organization: Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University
– sequence: 5
  givenname: Shiqi
  surname: Tang
  fullname: Tang, Shiqi
  organization: Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University
– sequence: 6
  givenname: Yujuan
  surname: Chai
  fullname: Chai, Yujuan
  organization: Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University
– sequence: 7
  givenname: Zhourui
  surname: Xu
  fullname: Xu, Zhourui
  organization: Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University
– sequence: 8
  givenname: Meirong
  surname: Li
  fullname: Li, Meirong
  organization: Central Laboratory of Longgang District People’s Hospital of Shenzhen & The Second Affiliated Hospital, The Chinese University of Hong Kong, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University
– sequence: 9
  givenname: Xin
  surname: Chen
  fullname: Chen, Xin
  organization: Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University
– sequence: 10
  givenname: Jia
  surname: Liu
  fullname: Liu, Jia
  email: liujia870702@126.com
  organization: Central Laboratory of Longgang District People’s Hospital of Shenzhen & The Second Affiliated Hospital, The Chinese University of Hong Kong
– sequence: 11
  givenname: Chengbin
  surname: Yang
  fullname: Yang, Chengbin
  email: cbyang@szu.edu.cn
  organization: Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35701788$$D View this record in MEDLINE/PubMed
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Keywords Delivery
Gene therapy
Exosome
Cancer treatment
Nucleic acid drug
Language English
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Snippet Cancer is a leading public health problem worldwide. Its treatment remains a daunting challenge, although significant progress has been made in existing...
Abstract Cancer is a leading public health problem worldwide. Its treatment remains a daunting challenge, although significant progress has been made in...
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SubjectTerms Acids
Analysis
B cells
Bioavailability
Biocompatibility
Biosynthesis
Biotechnology
Cancer
Cancer therapies
Cancer treatment
Care and treatment
Chemistry
Chemistry and Materials Science
Chemotherapy
Circular RNA
Clinical trials
Delivery
Deoxyribonucleic acid
DNA
Dosage and administration
Drug development
Drugs
Efficiency
Exosome
Exosomes
Extracellular vesicles
Gene expression
Gene therapy
Genetic engineering
Immunogenicity
Lipids
MicroRNA
MicroRNAs
miRNA
Molecular Medicine
mRNA
Nanotechnology
Nucleic acid drug
Nucleic acids
Proteins
Public health
Review
Ribonucleic acid
RNA
siRNA
Toxicity
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Title Recent advances in exosome-mediated nucleic acid delivery for cancer therapy
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