Role of CD47 in Hematological Malignancies

CD47, or integrin-associated protein, is a cell surface ligand expressed in low levels by nearly all cells of the body. It plays an integral role in various immune responses as well as autoimmunity, by sending a potent “don’t eat me” signal to prevent phagocytosis. A growing body of evidence demonst...

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Bibliographic Details
Published in:Journal of hematology and oncology Vol. 13; no. 1; pp. 96 - 14
Main Authors: Eladl, Entsar, Tremblay-LeMay, Rosemarie, Rastgoo, Nasrin, Musani, Rumina, Chen, Wenming, Liu, Aijun, Chang, Hong
Format: Journal Article
Language:English
Published: London BioMed Central 16.07.2020
BioMed Central Ltd
Springer Nature B.V
BMC
Subjects:
Angiogenic Proteins - metabolism
Animals
Antibodies
Antibodies, Monoclonal, Humanized - therapeutic use
Antigens, Differentiation - metabolism
Antineoplastic Agents, Immunological - therapeutic use
Apoptosis
Autoimmunity
Blood cancer
Cancer
Cancer metastasis
Cancer prevention
Cancer Research
Cancer therapies
CD47
CD47 Antigen - antagonists & inhibitors
CD47 Antigen - physiology
Cell surface
Clinical trials
Clinical Trials as Topic
Cytochrome
Drug Delivery Systems
Drug Design
Drug Screening Assays, Antitumor
Extracellular matrix
Gene expression
Hematologic Neoplasms - physiopathology
Hematologic Neoplasms - therapy
Hematological cancers
Hematology
Humans
Immune response
Immune system
Immunoglobulins
Immunotherapy
Integrins
Integrins - metabolism
Kinases
Leukemia - metabolism
Leukemia - physiopathology
Ligands
Lymphatic system
Lymphoma
Lymphoma, Non-Hodgkin - metabolism
Lymphoma, Non-Hodgkin - physiopathology
Medical prognosis
Medical research
Medicine
Medicine & Public Health
Metastases
Molecular Mimicry
Molecular Targeted Therapy
Myeloid Cells - metabolism
Neoplasia
Neoplasm Metastasis
Neoplasm Proteins - antagonists & inhibitors
Neoplasm Proteins - physiology
Oligopeptides - therapeutic use
Oncology
Phagocytes
Phagocytosis
Phosphorylation
Protein Binding
Protein Domains
Protein Interaction Mapping
Proteins
Receptors, Immunologic - antagonists & inhibitors
Receptors, Immunologic - metabolism
Review
Signal transduction
Signal Transduction - physiology
Smooth muscle
Surface markers
Targeted therapy
Therapeutic applications
Tumors
CD47
Targeted therapy
Hematological cancers
Immunotherapy
ISSN:1756-8722, 1756-8722
Online Access:Get full text
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Summary:CD47, or integrin-associated protein, is a cell surface ligand expressed in low levels by nearly all cells of the body. It plays an integral role in various immune responses as well as autoimmunity, by sending a potent “don’t eat me” signal to prevent phagocytosis. A growing body of evidence demonstrates that CD47 is overexpressed in various hematological malignancies and its interaction with SIRPα on the phagocytic cells prevents phagocytosis of cancer cells. Additionally, it is expressed by different cell types in the tumor microenvironment and is required for establishing tumor metastasis. Overexpression of CD47 is thus often associated with poor clinical outcomes. CD47 has emerged as a potential therapeutic target and is being investigated in various preclinical studies as well as clinical trials to prove its safety and efficacy in treating hematological neoplasms. This review focuses on different therapeutic mechanisms to target CD47, either alone or in combination with other cell surface markers, and its pivotal role in impairing tumor growth and metastatic spread of various types of hematological malignancies.
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ISSN:1756-8722
1756-8722
DOI:10.1186/s13045-020-00930-1