Role of CD47 in Hematological Malignancies

CD47, or integrin-associated protein, is a cell surface ligand expressed in low levels by nearly all cells of the body. It plays an integral role in various immune responses as well as autoimmunity, by sending a potent “don’t eat me” signal to prevent phagocytosis. A growing body of evidence demonst...

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Vydané v:	Journal of hematology and oncology Ročník 13; číslo 1; s. 96 - 14
Hlavní autori:	Eladl, Entsar, Tremblay-LeMay, Rosemarie, Rastgoo, Nasrin, Musani, Rumina, Chen, Wenming, Liu, Aijun, Chang, Hong
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London BioMed Central 16.07.2020 BioMed Central Ltd Springer Nature B.V BMC
Predmet:	Angiogenic Proteins - metabolism Animals Antibodies Antibodies, Monoclonal, Humanized - therapeutic use Antigens, Differentiation - metabolism Antineoplastic Agents, Immunological - therapeutic use Apoptosis Autoimmunity Blood cancer Cancer Cancer metastasis Cancer prevention Cancer Research Cancer therapies CD47 CD47 Antigen - antagonists & inhibitors CD47 Antigen - physiology Cell surface Clinical trials Clinical Trials as Topic Cytochrome Drug Delivery Systems Drug Design Drug Screening Assays, Antitumor Extracellular matrix Gene expression Hematologic Neoplasms - physiopathology Hematologic Neoplasms - therapy Hematological cancers Hematology Humans Immune response Immune system Immunoglobulins Immunotherapy Integrins Integrins - metabolism Kinases Leukemia - metabolism Leukemia - physiopathology Ligands Lymphatic system Lymphoma Lymphoma, Non-Hodgkin - metabolism Lymphoma, Non-Hodgkin - physiopathology Medical prognosis Medical research Medicine Medicine & Public Health Metastases Molecular Mimicry Molecular Targeted Therapy Myeloid Cells - metabolism Neoplasia Neoplasm Metastasis Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - physiology Oligopeptides - therapeutic use Oncology Phagocytes Phagocytosis Phosphorylation Protein Binding Protein Domains Protein Interaction Mapping Proteins Receptors, Immunologic - antagonists & inhibitors Receptors, Immunologic - metabolism Review Signal transduction Signal Transduction - physiology Smooth muscle Surface markers Targeted therapy Therapeutic applications Tumors CD47 Targeted therapy Hematological cancers Immunotherapy
ISSN:	1756-8722, 1756-8722
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Popis
Shrnutí:	CD47, or integrin-associated protein, is a cell surface ligand expressed in low levels by nearly all cells of the body. It plays an integral role in various immune responses as well as autoimmunity, by sending a potent “don’t eat me” signal to prevent phagocytosis. A growing body of evidence demonstrates that CD47 is overexpressed in various hematological malignancies and its interaction with SIRPα on the phagocytic cells prevents phagocytosis of cancer cells. Additionally, it is expressed by different cell types in the tumor microenvironment and is required for establishing tumor metastasis. Overexpression of CD47 is thus often associated with poor clinical outcomes. CD47 has emerged as a potential therapeutic target and is being investigated in various preclinical studies as well as clinical trials to prove its safety and efficacy in treating hematological neoplasms. This review focuses on different therapeutic mechanisms to target CD47, either alone or in combination with other cell surface markers, and its pivotal role in impairing tumor growth and metastatic spread of various types of hematological malignancies.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	1756-8722 1756-8722
DOI:	10.1186/s13045-020-00930-1