Role of CD47 in Hematological Malignancies

CD47, or integrin-associated protein, is a cell surface ligand expressed in low levels by nearly all cells of the body. It plays an integral role in various immune responses as well as autoimmunity, by sending a potent “don’t eat me” signal to prevent phagocytosis. A growing body of evidence demonst...

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Bibliographic Details
Published in:	Journal of hematology and oncology Vol. 13; no. 1; pp. 96 - 14
Main Authors:	Eladl, Entsar, Tremblay-LeMay, Rosemarie, Rastgoo, Nasrin, Musani, Rumina, Chen, Wenming, Liu, Aijun, Chang, Hong
Format:	Journal Article
Language:	English
Published:	London BioMed Central 16.07.2020 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Angiogenic Proteins - metabolism Animals Antibodies Antibodies, Monoclonal, Humanized - therapeutic use Antigens, Differentiation - metabolism Antineoplastic Agents, Immunological - therapeutic use Apoptosis Autoimmunity Blood cancer Cancer Cancer metastasis Cancer prevention Cancer Research Cancer therapies CD47 CD47 Antigen - antagonists & inhibitors CD47 Antigen - physiology Cell surface Clinical trials Clinical Trials as Topic Cytochrome Drug Delivery Systems Drug Design Drug Screening Assays, Antitumor Extracellular matrix Gene expression Hematologic Neoplasms - physiopathology Hematologic Neoplasms - therapy Hematological cancers Hematology Humans Immune response Immune system Immunoglobulins Immunotherapy Integrins Integrins - metabolism Kinases Leukemia - metabolism Leukemia - physiopathology Ligands Lymphatic system Lymphoma Lymphoma, Non-Hodgkin - metabolism Lymphoma, Non-Hodgkin - physiopathology Medical prognosis Medical research Medicine Medicine & Public Health Metastases Molecular Mimicry Molecular Targeted Therapy Myeloid Cells - metabolism Neoplasia Neoplasm Metastasis Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - physiology Oligopeptides - therapeutic use Oncology Phagocytes Phagocytosis Phosphorylation Protein Binding Protein Domains Protein Interaction Mapping Proteins Receptors, Immunologic - antagonists & inhibitors Receptors, Immunologic - metabolism Review Signal transduction Signal Transduction - physiology Smooth muscle Surface markers Targeted therapy Therapeutic applications Tumors CD47 Targeted therapy Hematological cancers Immunotherapy
ISSN:	1756-8722, 1756-8722
Online Access:	Get full text
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