Dendritic cell biology and its role in tumor immunotherapy

As crucial antigen presenting cells, dendritic cells (DCs) play a vital role in tumor immunotherapy. Taking into account the many recent advances in DC biology, we discuss how DCs (1) recognize pathogenic antigens with pattern recognition receptors through specific phagocytosis and through non-speci...

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Vydáno v:	Journal of hematology and oncology Ročník 13; číslo 1; s. 107 - 18
Hlavní autoři:	Wang, Yingying, Xiang, Ying, Xin, Victoria W., Wang, Xian-Wang, Peng, Xiao-Chun, Liu, Xiao-Qin, Wang, Dong, Li, Na, Cheng, Jun-Ting, Lyv, Yan-Ning, Cui, Shu-Zhong, Ma, Zhaowu, Zhang, Qing, Xin, Hong-Wu
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London BioMed Central 03.08.2020 BioMed Central Ltd Springer Nature B.V BMC
Témata:	Animals Antigen (tumor-associated) Antigen presentation Antigen Presentation - immunology Antigen-presenting cells Antigens Antigens, Neoplasm - immunology Autophagy Autophagy - immunology Cancer Research Carbohydrates Caspase-11 CD4 antigen CD8 antigen Cell adhesion & migration Chemokines Clinical trials Clinical Trials as Topic Cytokines Dendritic cells Dendritic cells (DCs) Dendritic Cells - immunology Exosomes Exosomes - immunology Hematology Histocompatibility antigen HLA Histocompatibility Antigens Class I - immunology Humans Immune cells Immune response Immunoglobulin G Immunologic Memory Immunologic Surveillance Immunological memory Immunosurveillance Immunotherapy Lectins Lectins, C-Type - immunology Lymphocyte Activation Lymphocyte Subsets - immunology Lymphocytes Lymphocytes T Major histocompatibility complex Medical research Medicine Medicine & Public Health Medicine, Experimental Melanoma Memory cells MHC Mice Models, Immunological Neoantigens Neoplasms - immunology Neoplasms - therapy Oncology Pathogens Pattern recognition receptors Peptides Phagocytosis Physiology Protein Conformation Proteins Receptors, Antigen, T-Cell - chemistry Receptors, Antigen, T-Cell - immunology Receptors, Fc - immunology Receptors, Immunologic - immunology Review T cell receptors Tumor antigens Tumor immunotherapy Tumor Microenvironment Tumors Vaccines MHC Tumor immunotherapy Dendritic cells (DCs) Immune cells
ISSN:	1756-8722, 1756-8722
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Popis
Shrnutí:	As crucial antigen presenting cells, dendritic cells (DCs) play a vital role in tumor immunotherapy. Taking into account the many recent advances in DC biology, we discuss how DCs (1) recognize pathogenic antigens with pattern recognition receptors through specific phagocytosis and through non-specific micropinocytosis, (2) process antigens into small peptides with proper sizes and sequences, and (3) present MHC-peptides to CD4 + and CD8 + T cells to initiate immune responses against invading microbes and aberrant host cells. During anti-tumor immune responses, DC-derived exosomes were discovered to participate in antigen presentation. T cell microvillar dynamics and TCR conformational changes were demonstrated upon DC antigen presentation. Caspase-11-driven hyperactive DCs were recently reported to convert effectors into memory T cells. DCs were also reported to crosstalk with NK cells. Additionally, DCs are the most important sentinel cells for immune surveillance in the tumor microenvironment. Alongside DC biology, we review the latest developments for DC-based tumor immunotherapy in preclinical studies and clinical trials. Personalized DC vaccine-induced T cell immunity, which targets tumor-specific antigens, has been demonstrated to be a promising form of tumor immunotherapy in patients with melanoma. Importantly, allogeneic-IgG-loaded and HLA-restricted neoantigen DC vaccines were discovered to have robust anti-tumor effects in mice. Our comprehensive review of DC biology and its role in tumor immunotherapy aids in the understanding of DCs as the mentors of T cells and as novel tumor immunotherapy cells with immense potential.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	1756-8722 1756-8722
DOI:	10.1186/s13045-020-00939-6