Neutrophils in cancer carcinogenesis and metastasis

In recent years, neutrophils have attracted increasing attention because of their cancer-promoting effects. An elevated neutrophil-to-lymphocyte ratio is considered a prognostic indicator for patients with cancer. Neutrophils are no longer regarded as innate immune cells with a single function, let...

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Vydáno v:	Journal of hematology and oncology Ročník 14; číslo 1; s. 173 - 17
Hlavní autoři:	Xiong, Shumin, Dong, Liaoliao, Cheng, Lin
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London BioMed Central 21.10.2021 BioMed Central Ltd Springer Nature B.V BMC
Témata:	Adjuvant treatment Angiogenesis Animals Autoimmune diseases Bone marrow Cancer Cancer Research Carcinogenesis Carcinogenesis - immunology Carcinogenesis - pathology Cell plasticity Cell reprogramming Cellular Reprogramming Chemokines Colon Coronaviruses COVID-19 Development and progression Disease Progression DNA damage Genetic engineering Hematology Humans Infectious diseases Inflammation Leukocytes (neutrophilic) Liver cancer Lung cancer Lymphocytes Medicine Medicine & Public Health Metabolism Metastases Metastasis Microenvironment Microenvironments Mutation Neoplasm Metastasis - immunology Neoplasm Metastasis - pathology Neoplasm Recurrence, Local - immunology Neoplasm Recurrence, Local - pathology Neoplasms - immunology Neoplasms - pathology Neutrophil Neutrophils Neutrophils - immunology Neutrophils - pathology Nitric oxide Oncology Plasticity Review Tumor Microenvironment Type 2 diabetes Maryland Neutrophil Microenvironment Cell reprogramming Cancer Cell plasticity
ISSN:	1756-8722, 1756-8722
On-line přístup:	Získat plný text
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Popis
Shrnutí:	In recent years, neutrophils have attracted increasing attention because of their cancer-promoting effects. An elevated neutrophil-to-lymphocyte ratio is considered a prognostic indicator for patients with cancer. Neutrophils are no longer regarded as innate immune cells with a single function, let alone bystanders in the pathological process of cancer. Their diversity and plasticity are being increasingly recognized. This review summarizes previous studies assessing the roles and mechanisms of neutrophils in cancer initiation, progression, metastasis and relapse. Although the findings are controversial, the fact that neutrophils play a dual role in promoting and suppressing cancer is undeniable. The plasticity of neutrophils allows them to adapt to different cancer microenvironments and exert different effects on cancer. Given the findings from our own research, we propose a reasonable hypothesis that neutrophils may be reprogrammed into a cancer-promoting state in the cancer microenvironment. This new perspective indicates that neutrophil reprogramming in the course of cancer treatment is a problem worthy of attention. Preventing or reversing the reprogramming of neutrophils may be a potential strategy for adjuvant cancer therapy.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	1756-8722 1756-8722
DOI:	10.1186/s13045-021-01187-y