Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse

Escape of prostate cancer (PCa) cells from ionizing radiation-induced (IR-induced) killing leads to disease progression and cancer relapse. The influence of sphingolipids, such as ceramide and its metabolite sphingosine 1-phosphate, on signal transduction pathways under cell stress is important to s...

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Bibliographic Details
Published in:	The Journal of clinical investigation Vol. 123; no. 10; pp. 4344 - 4358
Main Authors:	Cheng, Joseph C., Bai, Aiping, Beckham, Thomas H., Marrison, S. Tucker, Yount, Caroline L., Young, Katherine, Lu, Ping, Bartlett, Anne M., Wu, Bill X., Keane, Barry J., Armeson, Kent E., Marshall, David T., Keane, Thomas E., Smith, Michael T., Jones, E. Ellen, Drake, Richard R., Bielawska, Alicja, Norris, James S., Liu, Xiang
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 01.10.2013
Subjects:	Acid Ceramidase - antagonists & inhibitors Acid Ceramidase - genetics Acid Ceramidase - metabolism Amides - administration & dosage Amides - pharmacology Animals Biomedical research Cancer therapies Care and treatment Cell culture Cell Line, Tumor Enzyme Induction - radiation effects Enzymes Gene Expression Gene Expression Regulation, Neoplastic - radiation effects Genetic aspects Humans Hydrolases Injections, Intraperitoneal Ionizing radiation Kinases Male Mice Mice, Nude Neoplasm Recurrence, Local - enzymology Neoplasm Recurrence, Local - prevention & control Promoter Regions, Genetic Propanolamines - administration & dosage Propanolamines - pharmacology Properties Prostate cancer Prostatic Neoplasms - enzymology Prostatic Neoplasms - pathology Prostatic Neoplasms - radiotherapy Protein Binding Proteins Proto-Oncogene Proteins c-jun - metabolism Radiation therapy Radiation Tolerance Radiation-Sensitizing Agents - administration & dosage Radiation-Sensitizing Agents - pharmacology Radiotherapy Sphingolipids - metabolism Studies Transcription Factor AP-1 - metabolism Transcriptional Activation - radiation effects Tumors Xenograft Model Antitumor Assays United States
ISSN:	0021-9738, 1558-8238, 1558-8238
Online Access:	Get full text
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