Oxido-reductive regulation of vascular remodeling by receptor tyrosine kinase ROS1

Angioplasty and stenting is the primary treatment for flow-limiting atherosclerosis; however, this strategy is limited by pathological vascular remodeling. Using a systems approach, we identified a role for the network hub gene glutathione peroxidase-1 (GPX1) in pathological remodeling following hum...

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Bibliographic Details
Published in:	The Journal of clinical investigation Vol. 124; no. 12; pp. 5159 - 5174
Main Authors:	Ali, Ziad A., de Jesus Perez, Vinicio, Yuan, Ke, Orcholski, Mark, Pan, Stephen, Qi, Wei, Chopra, Gaurav, Adams, Christopher, Kojima, Yoko, Leeper, Nicholas J., Qu, Xiumei, Zaleta-Rivera, Kathia, Kato, Kimihiko, Yamada, Yoshiji, Oguri, Mitsutoshi, Kuchinsky, Allan, Hazen, Stanley L., Jukema, J. Wouter, Ganesh, Santhi K., Nabel, Elizabeth G., Channon, Keith, Leon, Martin B., Charest, Alain, Quertermous, Thomas, Ashley, Euan A.
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 01.12.2014
Subjects:	Amino Acid Substitution Analysis Animals Atherosclerosis Atherosclerosis - enzymology Atherosclerosis - genetics Atherosclerosis - pathology Biomedical research Cardiovascular disease Cells, Cultured Coronary vessels Crizotinib Diabetes Female Gene expression Gene Expression Regulation, Enzymologic - drug effects Gene Expression Regulation, Enzymologic - genetics Genetic aspects Genomics Glutathione Peroxidase - biosynthesis Glutathione Peroxidase - genetics Glutathione Peroxidase GPX1 Grants Humans Kinases Laboratory animals Male Mice Mice, Knockout Muscle Proteins - antagonists & inhibitors Muscle Proteins - genetics Muscle Proteins - metabolism Muscle, Smooth, Vascular - enzymology Muscle, Smooth, Vascular - pathology Mutation, Missense Myocytes, Smooth Muscle - enzymology Myocytes, Smooth Muscle - pathology Oxidation-Reduction Oxidative Stress - drug effects Oxidative Stress - genetics Phosphatase Physiological aspects Protein Kinase Inhibitors - pharmacology Protein kinases Protein-Tyrosine Kinases - antagonists & inhibitors Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins - antagonists & inhibitors Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Pyrazoles - pharmacology Pyridines - pharmacology Receptor Protein-Tyrosine Kinases - antagonists & inhibitors Receptor Protein-Tyrosine Kinases - genetics Receptor Protein-Tyrosine Kinases - metabolism Risk factors Smooth muscle Stents Studies Thrombosis Vascular Remodeling Vascular smooth muscle United States United States > US
ISSN:	0021-9738, 1558-8238, 1558-8238
Online Access:	Get full text
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