Decreased somatic hypermutation induces an impaired peripheral B cell tolerance checkpoint

Patients with mutations in AICDA, which encodes activation-induced cytidine deaminase (AID), display an impaired peripheral B cell tolerance. AID mediates class-switch recombination (CSR) and somatic hypermutation (SHM) in B cells, but the mechanism by which AID prevents the accumulation of autoreac...

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Veröffentlicht in:	The Journal of clinical investigation Jg. 126; H. 11; S. 4289 - 4302
Hauptverfasser:	Cantaert, Tineke, Schickel, Jean-Nicolas, Bannock, Jason M., Ng, Yen-Shing, Massad, Christopher, Delmotte, Fabien R., Yamakawa, Natsuko, Glauzy, Salome, Chamberlain, Nicolas, Kinnunen, Tuure, Menard, Laurence, Lavoie, Aubert, Walter, Jolan E., Notarangelo, Luigi D., Bruneau, Julie, Al-Herz, Waleed, Kilic, Sara Sebnem, Ochs, Hans D., Cunningham-Rundles, Charlotte, van der Burg, Mirjam, Kuijpers, Taco W., Kracker, Sven, Kaneko, Hideo, Sekinaka, Yujin, Nonoyama, Shigeaki, Durandy, Anne, Meffre, Eric
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States American Society for Clinical Investigation 01.11.2016
Schlagworte:	Analysis Autoimmunity B cells B-Lymphocytes - immunology B-Lymphocytes - pathology Biomedical research Cell Cycle Checkpoints - genetics Cell Cycle Checkpoints - immunology Cloning Cytidine Deaminase - deficiency Cytidine Deaminase - immunology Cytokines Defects Experiments Female Gene mutations Health aspects Humans Immune Tolerance Immunoglobulins Immunologic Memory Interleukins Lymphocyte receptors Male Mutation Physiological aspects R&D Research & development Somatic Hypermutation, Immunoglobulin - immunology Studies T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - pathology Massachusetts
ISSN:	0021-9738, 1558-8238, 1558-8238
Online-Zugang:	Volltext
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