Smoking-induced aggravation of experimental arthritis is dependent of aryl hydrocarbon receptor activation in Th17 cells

Background Epidemiologic studies have highlighted the association of environmental factors with the development and progression of autoimmune and chronic inflammatory diseases. Among the environmental factors, smoking has been associated with increased susceptibility and poor prognosis in rheumatoid...

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Published in:	Arthritis research & therapy Vol. 20; no. 1; pp. 119 - 11
Main Authors:	Talbot, Jhimmy, Peres, Raphael S., Pinto, Larissa G., Oliveira, Rene D. R., Lima, Kalil A., Donate, Paula B., Silva, Jaqueline R., Ryffel, Bernard, Cunha, Thiago M., Alves-Filho, José C., Liew, Foo Y., Louzada-Junior, Paulo, de Queiroz Cunha, Fernando
Format:	Journal Article
Language:	English
Published:	London BioMed Central 08.06.2018 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Animals Antigens Aromatic compounds Arthritis Arthritis, Experimental - etiology Arthritis, Experimental - genetics Arthritis, Experimental - metabolism Atherosclerosis Azo Compounds - pharmacology Cigarette smoke Cigarettes Collagen Cytokines Development and progression Drug dosages Health aspects Health risk assessment Hydrocarbons Hyperalgesia Inflammation Inflammatory bowel disease Life Sciences Male Medicine Medicine & Public Health Mice, Inbred C57BL Mice, Inbred DBA Mice, Knockout Neutrophils Nicotiana - chemistry Orthopedics Pathogens Pollutants Polycyclic aromatic hydrocarbons Pyrazoles - pharmacology Receptors, Aryl Hydrocarbon - antagonists & inhibitors Receptors, Aryl Hydrocarbon - genetics Receptors, Aryl Hydrocarbon - metabolism Receptors, Interleukin-17 - genetics Receptors, Interleukin-17 - metabolism Research Article Rheumatoid arthritis Rheumatology Rodents Smoke - adverse effects Smoking Th17 Th17 Cells - metabolism Transcription factors France United States > US Inflammation Polycyclic aromatic hydrocarbons Th17 Rheumatoid arthritis Cigarette smoke
ISSN:	1478-6362, 1478-6354, 1478-6362
Online Access:	Get full text
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