Somatic mutation load of estrogen receptor-positive breast tumors predicts overall survival: an analysis of genome sequence data

Breast cancer is one of the most commonly diagnosed cancers in women. While there are several effective therapies for breast cancer and important single gene prognostic/predictive markers, more than 40,000 women die from this disease every year. The increasing availability of large-scale genomic dat...

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Bibliographic Details
Published in:	Breast cancer research and treatment Vol. 146; no. 1; pp. 211 - 220
Main Authors:	Haricharan, Svasti, Bainbridge, Matthew N., Scheet, Paul, Brown, Powel H.
Format:	Journal Article
Language:	English
Published:	Boston Springer US 01.07.2014 Springer Springer Nature B.V
Subjects:	Adult Aged Analysis Biomarkers, Tumor Breast cancer Breast Neoplasms - genetics Breast Neoplasms - mortality Breast Neoplasms - pathology Brief Report Cancer Cancer research Computational Biology - methods Databases, Nucleic Acid DNA Damage DNA Repair Estrogen Estrogens Female Genetic aspects Genetic Association Studies Genomes Genomics Humans Medical diagnosis Medicine Medicine & Public Health Middle Aged Mutation Neoplasm Metastasis Neoplasm Staging Oncology Patient outcomes Phenols Prognosis Proportional Hazards Models Receptors, Estrogen - genetics Tumor Burden Tumors DNA damage repair Estrogen receptor Breast cancer Mutation load
ISSN:	0167-6806, 1573-7217, 1573-7217
Online Access:	Get full text
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