Neoantigen-specific immunity in low mutation burden colorectal cancers of the consensus molecular subtype 4

Background The efficacy of checkpoint blockade immunotherapies in colorectal cancer is currently restricted to a minority of patients diagnosed with mismatch repair-deficient tumors having high mutation burden. However, this observation does not exclude the existence of neoantigen-specific T cells i...

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Veröffentlicht in:	Genome medicine Jg. 11; H. 1; S. 87 - 15
Hauptverfasser:	van den Bulk, Jitske, Verdegaal, Els M. E., Ruano, Dina, Ijsselsteijn, Marieke E., Visser, Marten, van der Breggen, Ruud, Duhen, Thomas, van der Ploeg, Manon, de Vries, Natasja L., Oosting, Jan, Peeters, Koen C. M. J., Weinberg, Andrew D., Farina-Sarasqueta, Arantza, van der Burg, Sjoerd H., de Miranda, Noel F. C. C.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London BioMed Central 30.12.2019 BioMed Central Ltd Springer Nature B.V BMC
Schlagworte:	Adoptive T cell transfer (ACT) Antigenic determinants Antigens Antigens, Neoplasm - chemistry Antigens, Neoplasm - immunology Bioinformatics Biomedical and Life Sciences Biomedicine Blood cells Bone morphogenetic proteins Cancer Cancer immunotherapy Cancer patients Cancer Research Cancer treatment CD103 antigen CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - metabolism Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - immunology Colorectal Neoplasms - pathology Colorectal Neoplasms - therapy Deoxyribonucleic acid DNA DNA Mismatch Repair DNA-Binding Proteins - genetics Epitopes Epitopes - chemistry Epitopes - immunology Epitopes - pharmacology Gene expression Genetic aspects Genomes Health aspects Human Genetics Humans Immune checkpoint Immunotherapy Interferon-gamma - metabolism Low mutation burden Lymphocytes Lymphocytes T Lymphocytes, Tumor-Infiltrating - cytology Lymphocytes, Tumor-Infiltrating - drug effects Lymphocytes, Tumor-Infiltrating - metabolism Medical prognosis Medicine/Public Health Metabolomics Microfilament Proteins - genetics Mismatch repair Mismatch repair-proficient (MMR-p) Mutation Neoantigens Patients Peptides Peptides - chemical synthesis Peptides - pharmacology Pharmacy Scientific equipment industry Systems Biology T cells T-Lymphocyte Subsets - cytology T-Lymphocyte Subsets - metabolism Transcription Factors - genetics Transforming Growth Factor beta - metabolism Transforming growth factor-beta Transforming growth factors Tumor antigens Tumor immune microenvironment and immunotherapy Tumor-infiltrating lymphocytes Tumors United States Netherlands United States > US Adoptive T cell transfer (ACT) Tumor-infiltrating lymphocytes Mismatch repair-proficient (MMR-p) CMS Transforming growth factor-beta Cancer immunotherapy Neoantigen Low mutation burden
ISSN:	1756-994X, 1756-994X
Online-Zugang:	Volltext
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