Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus

A small clinical trial shows that short-term cold acclimation to moderately-cold temperature improves the glucose homeostasis of individuals with type 2 diabetes, without an appreciable activation of their brown adipose tissue. Cold exposure may be a potential therapy for diabetes by increasing brow...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Nature medicine Jg. 21; H. 8; S. 863 - 865
Hauptverfasser: Hanssen, Mark J W, Hoeks, Joris, Brans, Boudewijn, van der Lans, Anouk A J J, Schaart, Gert, van den Driessche, José J, Jörgensen, Johanna A, Boekschoten, Mark V, Hesselink, Matthijs K C, Havekes, Bas, Kersten, Sander, Mottaghy, Felix M, van Marken Lichtenbelt, Wouter D, Schrauwen, Patrick
Format: Journal Article
Sprache:Englisch
Veröffentlicht: New York Nature Publishing Group US 01.08.2015
Nature Publishing Group
Schlagworte:
38/61
631/443
631/443/319
692/163
692/308/575
82/80
Acclimatization
Adipose tissue
Adipose Tissue, Brown - metabolism
Aged
Biomedicine
Body fat
brief-communication
Cancer Research
Care and treatment
Chair Nutrition Metabolism and Genomics
Cold
Cold Temperature
Diabetes
Diabetes Mellitus, Type 2 - metabolism
Dosage and administration
Fluorodeoxyglucose F18
Glucose - metabolism
Glucose Transporter Type 4 - physiology
Health aspects
HNE Nutrition, Metabolism and Genomics
HNE Voeding, Metabolisme en Genomics
Humans
Infectious Diseases
Insulin
Insulin Resistance
Male
Medical research
Metabolic Diseases
Middle Aged
Molecular Medicine
Muscles
Neurosciences
Nutrition, Metabolism and Genomics
Translocation
Type 2 diabetes
VLAG
Voeding, Metabolisme en Genomica
ISSN:1078-8956, 1546-170X, 1546-170X
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A small clinical trial shows that short-term cold acclimation to moderately-cold temperature improves the glucose homeostasis of individuals with type 2 diabetes, without an appreciable activation of their brown adipose tissue. Cold exposure may be a potential therapy for diabetes by increasing brown adipose tissue (BAT) mass and activity. Here we report that 10 d of cold acclimation (14–15 °C) increased peripheral insulin sensitivity by ∼43% in eight type 2 diabetes subjects. Basal skeletal muscle GLUT4 translocation markedly increased, without effects on insulin signaling or AMP-activated protein kinase (AMPK) activation and only a minor increase in BAT glucose uptake.
Bibliographie:SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 14
ObjectType-Article-1
ObjectType-Feature-2
content type line 23
ISSN:1078-8956
1546-170X
1546-170X
DOI:10.1038/nm.3891