Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus

A small clinical trial shows that short-term cold acclimation to moderately-cold temperature improves the glucose homeostasis of individuals with type 2 diabetes, without an appreciable activation of their brown adipose tissue. Cold exposure may be a potential therapy for diabetes by increasing brow...

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Vydáno v:	Nature medicine Ročník 21; číslo 8; s. 863 - 865
Hlavní autoři:	Hanssen, Mark J W, Hoeks, Joris, Brans, Boudewijn, van der Lans, Anouk A J J, Schaart, Gert, van den Driessche, José J, Jörgensen, Johanna A, Boekschoten, Mark V, Hesselink, Matthijs K C, Havekes, Bas, Kersten, Sander, Mottaghy, Felix M, van Marken Lichtenbelt, Wouter D, Schrauwen, Patrick
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	New York Nature Publishing Group US 01.08.2015 Nature Publishing Group
Témata:	38/61 631/443 631/443/319 692/163 692/308/575 82/80 Acclimatization Adipose tissue Adipose Tissue, Brown - metabolism Aged Biomedicine Body fat brief-communication Cancer Research Care and treatment Chair Nutrition Metabolism and Genomics Cold Cold Temperature Diabetes Diabetes Mellitus, Type 2 - metabolism Dosage and administration Fluorodeoxyglucose F18 Glucose - metabolism Glucose Transporter Type 4 - physiology Health aspects HNE Nutrition, Metabolism and Genomics HNE Voeding, Metabolisme en Genomics Humans Infectious Diseases Insulin Insulin Resistance Male Medical research Metabolic Diseases Middle Aged Molecular Medicine Muscles Neurosciences Nutrition, Metabolism and Genomics Translocation Type 2 diabetes VLAG Voeding, Metabolisme en Genomica
ISSN:	1078-8956, 1546-170X, 1546-170X
On-line přístup:	Získat plný text
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Shrnutí:	A small clinical trial shows that short-term cold acclimation to moderately-cold temperature improves the glucose homeostasis of individuals with type 2 diabetes, without an appreciable activation of their brown adipose tissue. Cold exposure may be a potential therapy for diabetes by increasing brown adipose tissue (BAT) mass and activity. Here we report that 10 d of cold acclimation (14–15 °C) increased peripheral insulin sensitivity by ∼43% in eight type 2 diabetes subjects. Basal skeletal muscle GLUT4 translocation markedly increased, without effects on insulin signaling or AMP-activated protein kinase (AMPK) activation and only a minor increase in BAT glucose uptake.
Bibliografie:	SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 content type line 23
ISSN:	1078-8956 1546-170X 1546-170X
DOI:	10.1038/nm.3891