Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus

A small clinical trial shows that short-term cold acclimation to moderately-cold temperature improves the glucose homeostasis of individuals with type 2 diabetes, without an appreciable activation of their brown adipose tissue. Cold exposure may be a potential therapy for diabetes by increasing brow...

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Vydáno v:	Nature medicine Ročník 21; číslo 8; s. 863 - 865
Hlavní autoři:	Hanssen, Mark J W, Hoeks, Joris, Brans, Boudewijn, van der Lans, Anouk A J J, Schaart, Gert, van den Driessche, José J, Jörgensen, Johanna A, Boekschoten, Mark V, Hesselink, Matthijs K C, Havekes, Bas, Kersten, Sander, Mottaghy, Felix M, van Marken Lichtenbelt, Wouter D, Schrauwen, Patrick
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	New York Nature Publishing Group US 01.08.2015 Nature Publishing Group
Témata:	38/61 631/443 631/443/319 692/163 692/308/575 82/80 Acclimatization Adipose tissue Adipose Tissue, Brown - metabolism Aged Biomedicine Body fat brief-communication Cancer Research Care and treatment Chair Nutrition Metabolism and Genomics Cold Cold Temperature Diabetes Diabetes Mellitus, Type 2 - metabolism Dosage and administration Fluorodeoxyglucose F18 Glucose - metabolism Glucose Transporter Type 4 - physiology Health aspects HNE Nutrition, Metabolism and Genomics HNE Voeding, Metabolisme en Genomics Humans Infectious Diseases Insulin Insulin Resistance Male Medical research Metabolic Diseases Middle Aged Molecular Medicine Muscles Neurosciences Nutrition, Metabolism and Genomics Translocation Type 2 diabetes VLAG Voeding, Metabolisme en Genomica
ISSN:	1078-8956, 1546-170X, 1546-170X
On-line přístup:	Získat plný text
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Abstract	A small clinical trial shows that short-term cold acclimation to moderately-cold temperature improves the glucose homeostasis of individuals with type 2 diabetes, without an appreciable activation of their brown adipose tissue. Cold exposure may be a potential therapy for diabetes by increasing brown adipose tissue (BAT) mass and activity. Here we report that 10 d of cold acclimation (14–15 °C) increased peripheral insulin sensitivity by ∼43% in eight type 2 diabetes subjects. Basal skeletal muscle GLUT4 translocation markedly increased, without effects on insulin signaling or AMP-activated protein kinase (AMPK) activation and only a minor increase in BAT glucose uptake.
AbstractList	Cold exposure may be a potential therapy for diabetes by increasing brown adipose tissue (BAT) mass and activity. Here we report that 10 d of cold acclimation (14–15 °C) increased peripheral insulin sensitivity by ~43% in eight type 2 diabetes subjects. Basal skeletal muscle GLUT4 translocation markedly increased, without effects on insulin signaling or AMP-activated protein kinase (AMPK) activation and only a minor increase in BAT glucose uptake. Cold exposure may be a potential therapy for diabetes by increasing brown adipose tissue (BAT) mass and activity. Here we report that 10 d of cold acclimation (14-15 °C) increased peripheral insulin sensitivity by ∼43% in eight type 2 diabetes subjects. Basal skeletal muscle GLUT4 translocation markedly increased, without effects on insulin signaling or AMP-activated protein kinase (AMPK) activation and only a minor increase in BAT glucose uptake.Cold exposure may be a potential therapy for diabetes by increasing brown adipose tissue (BAT) mass and activity. Here we report that 10 d of cold acclimation (14-15 °C) increased peripheral insulin sensitivity by ∼43% in eight type 2 diabetes subjects. Basal skeletal muscle GLUT4 translocation markedly increased, without effects on insulin signaling or AMP-activated protein kinase (AMPK) activation and only a minor increase in BAT glucose uptake. Cold exposure may be a potential therapy for diabetes by increasing brown adipose tissue (BAT) mass and activity. Here we report that 10 d of cold acclimation (14-15 °C) increased peripheral insulin sensitivity by ∼43% in eight type 2 diabetes subjects. Basal skeletal muscle GLUT4 translocation markedly increased, without effects on insulin signaling or AMP-activated protein kinase (AMPK) activation and only a minor increase in BAT glucose uptake. A small clinical trial shows that short-term cold acclimation to moderately-cold temperature improves the glucose homeostasis of individuals with type 2 diabetes, without an appreciable activation of their brown adipose tissue. Cold exposure may be a potential therapy for diabetes by increasing brown adipose tissue (BAT) mass and activity. Here we report that 10 d of cold acclimation (14–15 °C) increased peripheral insulin sensitivity by ∼43% in eight type 2 diabetes subjects. Basal skeletal muscle GLUT4 translocation markedly increased, without effects on insulin signaling or AMP-activated protein kinase (AMPK) activation and only a minor increase in BAT glucose uptake. Cold exposure may be a potential therapy for diabetes by increasing brown adipose tissue (BAT) mass and activity. Here we report that 10 d of cold acclimation (1415 C) increased peripheral insulin sensitivity by ~43% in eight type 2 diabetes subjects. Basal skeletal muscle GLUT4 translocation markedly increased, without effects on insulin signaling or AMP-activated protein kinase (AMPK) activation and only a minor increase in BAT glucose uptake. Cold exposure may be a potential therapy for diabetes by increasing brown adipose tissue (BAT) mass and activity. Here we report that 10 d of cold acclimation (14-15°C) increased peripheral insulin sensitivity by ~43% in eight type 2 diabetes subjects. Basal skeletal muscle GLUT4 translocation markedly increased, without effects on insulin signaling or AMP-activated protein kinase (AMPK) activation and only a minor increase in BAT glucose uptake.
Audience	Academic
Author	Hesselink, Matthijs K C Schaart, Gert Mottaghy, Felix M Brans, Boudewijn van Marken Lichtenbelt, Wouter D Schrauwen, Patrick Hanssen, Mark J W Havekes, Bas van der Lans, Anouk A J J Hoeks, Joris van den Driessche, José J Jörgensen, Johanna A Boekschoten, Mark V Kersten, Sander
Author_xml	– sequence: 1 givenname: Mark J W surname: Hanssen fullname: Hanssen, Mark J W organization: Department of Human Biology, School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center – sequence: 2 givenname: Joris surname: Hoeks fullname: Hoeks, Joris organization: Department of Human Biology, School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center – sequence: 3 givenname: Boudewijn surname: Brans fullname: Brans, Boudewijn organization: Department of Nuclear Medicine, Maastricht University Medical Center – sequence: 4 givenname: Anouk A J J surname: van der Lans fullname: van der Lans, Anouk A J J organization: Department of Human Biology, School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center – sequence: 5 givenname: Gert surname: Schaart fullname: Schaart, Gert organization: Department of Human Movement Sciences, School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center – sequence: 6 givenname: José J surname: van den Driessche fullname: van den Driessche, José J organization: Department of Human Biology, School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center – sequence: 7 givenname: Johanna A surname: Jörgensen fullname: Jörgensen, Johanna A organization: Department of Human Biology, School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center – sequence: 8 givenname: Mark V surname: Boekschoten fullname: Boekschoten, Mark V organization: Division of Human Nutrition, Nutrition, Metabolism and Genomics group, Wageningen University – sequence: 9 givenname: Matthijs K C surname: Hesselink fullname: Hesselink, Matthijs K C organization: Department of Human Movement Sciences, School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center – sequence: 10 givenname: Bas surname: Havekes fullname: Havekes, Bas organization: Department of Internal Medicine, Division of Endocrinology and Metabolism, School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center – sequence: 11 givenname: Sander surname: Kersten fullname: Kersten, Sander organization: Division of Human Nutrition, Nutrition, Metabolism and Genomics group, Wageningen University – sequence: 12 givenname: Felix M surname: Mottaghy fullname: Mottaghy, Felix M organization: Department of Nuclear Medicine, Maastricht University Medical Center, Department of Nuclear Medicine, University Hospital Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen – sequence: 13 givenname: Wouter D surname: van Marken Lichtenbelt fullname: van Marken Lichtenbelt, Wouter D organization: Department of Human Biology, School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center – sequence: 14 givenname: Patrick surname: Schrauwen fullname: Schrauwen, Patrick email: p.schrauwen@maastrichtuniversity.nl organization: Department of Human Biology, School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/26147760$$D View this record in MEDLINE/PubMed
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Snippet	A small clinical trial shows that short-term cold acclimation to moderately-cold temperature improves the glucose homeostasis of individuals with type 2... Cold exposure may be a potential therapy for diabetes by increasing brown adipose tissue (BAT) mass and activity. Here we report that 10 d of cold acclimation...
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SubjectTerms	38/61 631/443 631/443/319 692/163 692/308/575 82/80 Acclimatization Adipose tissue Adipose Tissue, Brown - metabolism Aged Biomedicine Body fat brief-communication Cancer Research Care and treatment Chair Nutrition Metabolism and Genomics Cold Cold Temperature Diabetes Diabetes Mellitus, Type 2 - metabolism Dosage and administration Fluorodeoxyglucose F18 Glucose - metabolism Glucose Transporter Type 4 - physiology Health aspects HNE Nutrition, Metabolism and Genomics HNE Voeding, Metabolisme en Genomics Humans Infectious Diseases Insulin Insulin Resistance Male Medical research Metabolic Diseases Middle Aged Molecular Medicine Muscles Neurosciences Nutrition, Metabolism and Genomics Translocation Type 2 diabetes VLAG Voeding, Metabolisme en Genomica
Title	Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus
URI	https://link.springer.com/article/10.1038/nm.3891 https://www.ncbi.nlm.nih.gov/pubmed/26147760 https://www.proquest.com/docview/1702101511 https://www.proquest.com/docview/1702659720 http://www.narcis.nl/publication/RecordID/oai:library.wur.nl:wurpubs%2F492663
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