Role of tumor suppressor p53 and micro-RNA interplay in multiple myeloma pathogenesis

The molecular mechanisms underlying dysregulated wild type (wt) p53 in multiple myeloma (MM) have been subjects of intense investigation for years. Indeed, correlation of rarely occurring TP53 gene mutations or deletions with adverse clinical outcomes in MM patients is strongly established, while in...

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Bibliographic Details
Published in:	Journal of hematology and oncology Vol. 10; no. 1; pp. 169 - 11
Main Authors:	Abdi, Jahangir, Rastgoo, Nasrin, Li, Lihong, Chen, Wenming, Chang, Hong
Format:	Journal Article
Language:	English
Published:	London BioMed Central 26.10.2017 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Apoptosis Cancer Cancer Research Causes of Cell cycle Development and progression Disease resistance Drug resistance Exploration Gene expression Genetic aspects Hematology Humans Leukemia Medicine Medicine & Public Health Micro-RNA MicroRNA MicroRNAs - metabolism miRNA Molecular modelling Multiple myeloma Multiple Myeloma - genetics Multiple Myeloma - metabolism Multiple Myeloma - pathology Mutation Myeloma Oncology p53 p53 Protein Pathogenesis Physiological aspects Regulatory sequences Review Tumor suppressor genes Tumor Suppressor Protein p53 - metabolism Canada Micro-RNA Myeloma p53
ISSN:	1756-8722, 1756-8722
Online Access:	Get full text
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