Role of immune cells in the removal of deleterious senescent cells

Cellular senescence is an essentially irreversible arrest of cell proliferation coupled to a complex senescence-associated secretory phenotype (SASP). The senescence arrest prevents the development of cancer, and the SASP can promote tissue repair. Recent data suggest that the prolonged presence of...

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Vydáno v:Immunity & ageing Ročník 17; číslo 1; s. 16 - 9
Hlavní autoři: Kale, Abhijit, Sharma, Amit, Stolzing, Alexandra, Desprez, Pierre-Yves, Campisi, Judith
Médium: Journal Article
Jazyk:angličtina
Vydáno: London BioMed Central 03.06.2020
BioMed Central Ltd
Springer Nature B.V
BMC
Témata:
Age
Age-related pathology
Aging
Antibodies
Arthritis
Atherosclerosis
BASIC BIOLOGICAL SCIENCES
Biomedical and Life Sciences
Biomedicine
Cancer
Care and treatment
Cell cycle
Cell proliferation
Cell-based therapy
Cellular senescence
Chemokines
Clinical Nutrition
Cyclin-dependent kinases
Cytokines
Deoxyribonucleic acid
Disease
DNA
Drugs
Genotype & phenotype
Geriatrics/Gerontology
Health aspects
Homeostasis
Immune surveillance
Immune system
Immunology
Inflammation
Ionizing radiation
Killer cells
Kinases
Macrophages
Natural killer cells
Neutrophils
Nitric oxide
Pathogens
Phenotypes
Prevention
Public Health
Review
Senescence
Tumor necrosis factor-TNF
Cellular senescence
Cell-based therapy
Immune surveillance
Inflammation
Natural killer cells
Macrophages
Age-related pathology
ISSN:1742-4933, 1742-4933
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Popis
Shrnutí:Cellular senescence is an essentially irreversible arrest of cell proliferation coupled to a complex senescence-associated secretory phenotype (SASP). The senescence arrest prevents the development of cancer, and the SASP can promote tissue repair. Recent data suggest that the prolonged presence of senescent cells, and especially the SASP, could be deleterious, and their beneficial effects early in life can become maladaptive such that they drive aging phenotypes and pathologies late in life. It is therefore important to develop strategies to eliminate senescent cells. There are currently under development or approved several immune cell-based therapies for cancer, which could be redesigned to target senescent cells. This review focuses on this possible use of immune cells and discusses how current cell-based therapies could be used for senescent cell removal.
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AC02-05CH11231
USDOE Office of Science (SC)
ISSN:1742-4933
1742-4933
DOI:10.1186/s12979-020-00187-9