In vivo neuronal firing patterns during human epileptiform discharges replicated by electrical stimulation

► The neuronal firing patterns during interictal epileptiform discharges (IEDs) and after single pulse electrical stimulation (SPES) can be described as burst-only, suppression-only, burst–suppression or no-change. ► Similar neuronal firing patterns can be observed during IEDs and after SPES. ► IEDs...

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Bibliographic Details
Published in:Clinical neurophysiology Vol. 123; no. 9; pp. 1736 - 1744
Main Authors: Alarcón, Gonzalo, Martinez, Juan, Kerai, Shashivadan V., Lacruz, Maria E., Quiroga, Rodrigo Quian, Selway, Richard P., Richardson, Mark P., García Seoane, Jorge J., Valentín, Antonio
Format: Journal Article
Language:English
Published: Oxford Elsevier Ireland Ltd 01.09.2012
Elsevier
Subjects:
Action Potentials - physiology
Adult
Biological and medical sciences
Brain - pathology
Brain Waves - physiology
Cognitive ability
Electric Stimulation - methods
Electrical stimuli
Electrodes, Implanted
Electrodiagnosis. Electric activity recording
Electroencephalography - methods
Epilepsy
Epilepsy - pathology
Epilepsy - physiopathology
Epileptiform discharge
Extracellular recording
Female
Firing pattern
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Human
Humans
In vivo
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
Nervous system
Nervous system (semeiology, syndromes)
Neurology
Neurons - physiology
Pathophysiology
Single pulse electrical stimulation
Single unit activity
SPES
Substance P
Young Adult
Human
In vivo
Extracellular recording
Pathophysiology
Epileptiform discharge
EEG
Epilepsy
Single unit activity
IEDs
SPES
Single pulse electrical stimulation
single pulse electrical stimulation
interictal epileptiform discharges
electroencephalogram
Nervous system diseases
Electrical activity
Electrical stimulus
Suppression
Discharge pattern
Electrophysiology
Electroencephalography
Depth
Cerebral disorder
Electrodes
Neuron
Central nervous system disease
Microelectrode
Burst
High frequency
ISSN:1388-2457, 1872-8952, 1872-8952
Online Access:Get full text
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Summary:► The neuronal firing patterns during interictal epileptiform discharges (IEDs) and after single pulse electrical stimulation (SPES) can be described as burst-only, suppression-only, burst–suppression or no-change. ► Similar neuronal firing patterns can be observed during IEDs and after SPES. ► IEDs and responses to SPES appear to activate similar and generic cortical mechanisms, which may explain transient cognitive impairment. To describe neuronal firing patterns observed during human spontaneous interictal epileptiform discharges (IEDs) and responses to single pulse electrical stimulation (SPES). Activity of single neurons was recorded during IEDs and after SPES in 11 consecutive patients assessed with depth EEG electrodes and attached microelectrodes. A total of 66 neurons were recorded during IEDs and 151 during SPES. We have found essentially similar patterns of neuronal firing during IEDs and after SPES, namely: (a) a burst of high frequency firing lasting less than 100ms (in 39% and 25% of local neurons, respectively for IED and SPES); (b) a period of suppression in firing lasting around 100–1300ms (in 19% and 14%, respectively); (c) a burst followed by suppression (in 10% and 12%, respectively); (d) no-change (in 32% and 50%, respectively). The similarities in neuronal firing patterns associated with IEDs and SPES suggest that, although both phenomena are initiated differently, they result in the activation of a common cortical mechanism, probably initiated by brief synchronised burst firing in some cells followed by long inhibition. The findings provide direct in vivo human evidence to further comprehend the pathophysiology of human focal epilepsy.
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Gonzalo Alarcon and Juan Martinez are joint first authors.
ISSN:1388-2457
1872-8952
1872-8952
DOI:10.1016/j.clinph.2012.02.062