Hantavirus inhibits apoptosis by preventing mitochondrial membrane potential loss through up-regulation of the pro-survival factor BCL-2

Hantaviruses, zoonotic RNA viruses belonging to the order Bunyavirales, cause two severe acute diseases in humans, hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). Hantavirus-infected patients show strong cytotoxic lymphocyte responses and hyperinflammation; howe...

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Bibliographic Details
Published in:	PLoS pathogens Vol. 16; no. 2; p. e1008297
Main Authors:	Solà-Riera, Carles, García, Marina, Ljunggren, Hans-Gustaf, Klingström, Jonas
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 07.02.2020 Public Library of Science (PLoS)
Subjects:	A549 Cells Apoptosis Bax protein Bcl-2 protein bcl-2-Associated X Protein - genetics bcl-2-Associated X Protein - metabolism Biology and Life Sciences Biotechnology industries Caspase-3 Caspase-8 Caspase-9 Caspases - genetics Caspases - metabolism Cell activation Cell survival Cytochrome Cytochrome c Cytochromes Cytochromes c - genetics Cytochromes c - metabolism Cytosol Cytotoxicity Disease resistance Diseases Experiments Exposure Fatalities Granzyme B Hantavirus Hantavirus infections Hantavirus pulmonary syndrome Health aspects Hemorrhage Hemorrhagic fever with renal syndrome Hemorrhagic Fever with Renal Syndrome - metabolism Hemorrhagic Fever with Renal Syndrome - pathology Hemorrhagic fevers Humans Immunopathogenesis Infections Inhibition Lymphocytes Major outer membrane protein Medical research Medicine Medicine and Health Sciences Membrane potential Membrane Potential, Mitochondrial Membranes Mitochondria Mitochondrial Membranes - metabolism Mitochondrial Membranes - pathology Proto-Oncogene Proteins c-bcl-2 - biosynthesis Proto-Oncogene Proteins c-bcl-2 - genetics Research and Analysis Methods RNA RNA viruses Scientific equipment industry siRNA Staurosporine Survival Survival factor Up-Regulation Viruses Zoonoses United States Sweden
ISSN:	1553-7374, 1553-7366, 1553-7374
Online Access:	Get full text
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