Insight in Genome-Wide Association of Metabolite Quantitative Traits by Exome Sequence Analyses

Metabolite quantitative traits carry great promise for epidemiological studies, and their genetic background has been addressed using Genome-Wide Association Studies (GWAS). Thus far, the role of less common variants has not been exhaustively studied. Here, we set out a GWAS for metabolite quantitat...

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Veröffentlicht in:	PLoS genetics Jg. 11; H. 1; S. e1004835
Hauptverfasser:	Demirkan, Ayşe, Henneman, Peter, Verhoeven, Aswin, Dharuri, Harish, Amin, Najaf, van Klinken, Jan Bert, Karssen, Lennart C., de Vries, Boukje, Meissner, Axel, Göraler, Sibel, van den Maagdenberg, Arn M. J. M., Deelder, André M., C ’t Hoen, Peter A., van Duijn, Cornelia M., van Dijk, Ko Willems
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 01.01.2015 Public Library of Science (PLoS)
Schlagworte:	DNA sequencing Exome - genetics Female Genetic aspects Genetic Predisposition to Disease Genome-wide association studies Genome-Wide Association Study Genomics Glycine - blood Humans Identification and classification Medicine and Health Sciences Metabolic disorders Metabolism, Inborn Errors Metabolites Metabolome - genetics Methods NMR Nuclear magnetic resonance Phenotype Polymorphism, Single Nucleotide Pyruvic Acid - blood Quantitative trait loci Quantitative Trait Loci - genetics Studies Valine - blood
ISSN:	1553-7404, 1553-7390, 1553-7404
Online-Zugang:	Volltext
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