Serotonin Activates Bacterial Quorum Sensing and Enhances the Virulence of Pseudomonas aeruginosa in the Host

Bacteria in humans play an important role in health and disease. Considerable emphasis has been placed in understanding the role of bacteria in host-microbiome interkingdom communication. Here we show that serotonin, responsible for mood in the brain and motility in the gut, can also act as a bacter...

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Bibliographic Details
Published in:	EBioMedicine Vol. 9; no. C; pp. 161 - 169
Main Authors:	Knecht, Leslie D., O'Connor, Gregory, Mittal, Rahul, Liu, Xue Z., Daftarian, Pirouz, Deo, Sapna K., Daunert, Sylvia
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.07.2016 Elsevier
Subjects:	Advanced Basic Science Animals Bacterial Proteins - metabolism Catalase - metabolism Cytokines - analysis Female Host-microbiome interactions Injections, Intraperitoneal Interkingdom signaling molecule Internal Medicine Intestines - metabolism Intestines - microbiology Intestines - pathology Las pathway Malondialdehyde - metabolism Mice Mice, Inbred C57BL Microscopy, Electron, Scanning N-acyl homoserine lactone Peptide Hydrolases - metabolism Peroxidase - metabolism Phenotype Pregnancy Pseudomonas aeruginosa Pseudomonas aeruginosa - enzymology Pseudomonas aeruginosa - metabolism Pseudomonas aeruginosa - physiology Quorum sensing Quorum Sensing - drug effects Research Paper Serotonin Serotonin - pharmacology Virulence - drug effects Serotonin Las pathway Pseudomonas aeruginosa Host-microbiome interactions Quorum sensing Interkingdom signaling molecule N-acyl homoserine lactone
ISSN:	2352-3964, 2352-3964
Online Access:	Get full text
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