Risk of stroke in hospitalized SARS-CoV-2 infected patients: A multinational study

There is an increased attention to stroke following SARS-CoV-2. The goal of this study was to better depict the short-term risk of stroke and its associated factors among SARS-CoV-2 hospitalized patients. This multicentre, multinational observational study includes hospitalized SARS-CoV-2 patients f...

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Published in:EBioMedicine Vol. 59; p. 102939
Main Authors: Shahjouei, Shima, Naderi, Soheil, Li, Jiang, Khan, Ayesha, Chaudhary, Durgesh, Farahmand, Ghasem, Male, Shailesh, Griessenauer, Christoph, Sabra, Mirna, Mondello, Stefania, Cernigliaro, Achille, Khodadadi, Faezeh, Dev, Apoorva, Goyal, Nitin, Ranji-Burachaloo, Sakineh, Olulana, Oluwaseyi, Avula, Venkatesh, Ebrahimzadeh, Seyed Amir, Alizada, Orkhan, Hancı, Mehmet Murat, Ghorbani, Askar, Vaghefi far, Alaleh, Ranta, Annemarei, Punter, Martin, Ramezani, Mahtab, Ostadrahimi, Nima, Tsivgoulis, Georgios, Fragkou, Paraskevi C., Nowrouzi-Sohrabi, Peyman, Karofylakis, Emmanouil, Tsiodras, Sotirios, Neshin Aghayari Sheikh, Saeideh, Saberi, Alia, Niemelä, Mika, Rezai Jahromi, Behnam, Mowla, Ashkan, Mashayekhi, Mahsa, Bavarsad Shahripour, Reza, Sajedi, Seyed Aidin, Ghorbani, Mohammad, Kia, Arash, Rahimian, Nasrin, Abedi, Vida, Zand, Ramin
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01.09.2020
Elsevier
Subjects:
Adult
Advanced Basic Science
Aged
Betacoronavirus - isolation & purification
Cerebrovascular disorders
Coronavirus Infections - complications
Coronavirus Infections - diagnosis
Coronavirus Infections - virology
COVID-19
Female
Hospitalization
Humans
Internal Medicine
Intracranial haemorrhage
Male
Middle Aged
Neurological complications
Pandemics
Pneumonia, Viral - complications
Pneumonia, Viral - diagnosis
Pneumonia, Viral - virology
Research paper
Risk Factors
SARS-CoV-2
Stroke
Stroke - complications
Stroke - diagnosis
Tertiary Care Centers
Venous thrombosis
COVID-19
Cerebrovascular disorders
Stroke
SARS-CoV-2
Neurological complications
Venous thrombosis
Intracranial haemorrhage
ISSN:2352-3964, 2352-3964
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Summary:There is an increased attention to stroke following SARS-CoV-2. The goal of this study was to better depict the short-term risk of stroke and its associated factors among SARS-CoV-2 hospitalized patients. This multicentre, multinational observational study includes hospitalized SARS-CoV-2 patients from North and South America (United States, Canada, and Brazil), Europe (Greece, Italy, Finland, and Turkey), Asia (Lebanon, Iran, and India), and Oceania (New Zealand). The outcome was the risk of subsequent stroke. Centres were included by non-probability sampling. The counts and clinical characteristics including laboratory findings and imaging of the patients with and without a subsequent stroke were recorded according to a predefined protocol. Quality, risk of bias, and heterogeneity assessments were conducted according to ROBINS-E and Cochrane Q-test. The risk of subsequent stroke was estimated through meta-analyses with random effect models. Bivariate logistic regression was used to determine the parameters with predictive outcome value. The study was reported according to the STROBE, MOOSE, and EQUATOR guidelines. We received data from 26,175 hospitalized SARS-CoV-2 patients from 99 tertiary centres in 65 regions of 11 countries until May 1st, 2020. A total of 17,799 patients were included in meta-analyses. Among them, 156(0.9%) patients had a stroke—123(79%) ischaemic stroke, 27(17%) intracerebral/subarachnoid hemorrhage, and 6(4%) cerebral sinus thrombosis. Subsequent stroke risks calculated with meta-analyses, under low to moderate heterogeneity, were 0.5% among all centres in all countries, and 0.7% among countries with higher health expenditures. The need for mechanical ventilation (OR: 1.9, 95% CI:1.1–3.5, p = 0.03) and the presence of ischaemic heart disease (OR: 2.5, 95% CI:1.4–4.7, p = 0.006) were predictive of stroke. The results of this multi-national study on hospitalized patients with SARS-CoV-2 infection indicated an overall stroke risk of 0.5%(pooled risk: 0.9%). The need for mechanical ventilation and the history of ischaemic heart disease are the independent predictors of stroke among SARS-CoV-2 patients. None.
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ISSN:2352-3964
2352-3964
DOI:10.1016/j.ebiom.2020.102939