Genome-Wide Association Study with Targeted and Non-targeted NMR Metabolomics Identifies 15 Novel Loci of Urinary Human Metabolic Individuality

Genome-wide association studies with metabolic traits (mGWAS) uncovered many genetic variants that influence human metabolism. These genetically influenced metabotypes (GIMs) contribute to our metabolic individuality, our capacity to respond to environmental challenges, and our susceptibility to spe...

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Veröffentlicht in:	PLoS genetics Jg. 11; H. 9; S. e1005487
Hauptverfasser:	Raffler, Johannes, Friedrich, Nele, Arnold, Matthias, Kacprowski, Tim, Rueedi, Rico, Altmaier, Elisabeth, Bergmann, Sven, Budde, Kathrin, Gieger, Christian, Homuth, Georg, Pietzner, Maik, Römisch-Margl, Werner, Strauch, Konstantin, Völzke, Henry, Waldenberger, Melanie, Wallaschofski, Henri, Nauck, Matthias, Völker, Uwe, Kastenmüller, Gabi, Suhre, Karsten
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 01.09.2015 Public Library of Science (PLoS)
Schlagworte:	Biomedical research Chromosome Mapping Datasets Funding Gene expression Genetic aspects Genetic Predisposition to Disease Genome-wide association studies Genome-Wide Association Study Genomes Grants Homeostasis Humans Kidneys Medicine Metabolism Metabolites Metabolomics Methods Nuclear magnetic resonance spectroscopy Proton Magnetic Resonance Spectroscopy Quantitative Trait Loci Studies Urine
ISSN:	1553-7404, 1553-7390, 1553-7404
Online-Zugang:	Volltext
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