Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1

An aged circulatory environment can activate microglia, reduce neural precursor cell activity and impair cognition in mice. We hypothesized that brain endothelial cells (BECs) mediate at least some of these effects. We observe that BECs in the aged mouse hippocampus express an inflammatory transcrip...

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Bibliographic Details
Published in:	Nature medicine Vol. 25; no. 6; pp. 988 - 1000
Main Authors:	Yousef, Hanadie, Czupalla, Cathrin J, Lee, Davis, Chen, Michelle B, Burke, Ashley N, Zera, Kristy A, Zandstra, Judith, Berber, Elisabeth, Lehallier, Benoit, Mathur, Vidhu, Nair, Ramesh V, Bonanno, Liana N, Yang, Andrew C, Peterson, Todd, Hadeiba, Husein, Merkel, Taylor, Körbelin, Jakob, Schwaninger, Markus, Buckwalter, Marion S, Quake, Stephen R, Butcher, Eugene C, Wyss-Coray, Tony
Format:	Journal Article
Language:	English
Published:	United States Nature Publishing Group 01.06.2019
Subjects:	Ablation Adolescent Adult Aged Aging Aging - blood Aging - immunology Aging - metabolism Animals Antibodies Blood Blood-Brain Barrier - immunology Blood-Brain Barrier - metabolism Brain Brain - cytology Brain - metabolism Cell adhesion Cell adhesion & migration Cell adhesion molecules Cell interactions Cells, Cultured Cognition Cognitive ability Endothelial cells Endothelial Cells - metabolism Female Gene Deletion Hippocampus Hippocampus - cytology Hippocampus - metabolism Humans Immune system Inflammation Inflammation Mediators - metabolism Male Mice Mice, Inbred NOD Mice, Knockout Mice, SCID Microglia Microglia - metabolism Neural Stem Cells - cytology Neural Stem Cells - metabolism Neurodegeneration Precursors Transcription Vascular cell adhesion molecule 1 Vascular Cell Adhesion Molecule-1 - blood Vascular Cell Adhesion Molecule-1 - genetics Vascular Cell Adhesion Molecule-1 - metabolism Young Adult
ISSN:	1078-8956, 1546-170X, 1546-170X
Online Access:	Get full text
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