How important is EMT for cancer metastasis?

Epithelial-to-mesenchymal transition (EMT), a biological phenomenon of cellular plasticity initially reported in embryonic development, has been increasingly recognized for its importance in cancer progression and metastasis. Despite tremendous progress being made in the past 2 decades in our unders...

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Vydáno v:PLoS biology Ročník 22; číslo 2; s. e3002487
Hlavní autoři: Celià-Terrassa, Toni, Kang, Yibin
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Public Library of Science 07.02.2024
Public Library of Science (PLoS)
Témata:
Analysis
Breast cancer
Cancer
Colorectal cancer
Embryogenesis
Embryonic development
Embryonic growth stage
Medical research
Medicine and Health Sciences
Metastases
Metastasis
Methods
Molecular modelling
Plastic foam
Stem cells
Transcription factors
Tumors
Unsolved Mystery
United States
ISSN:1545-7885, 1544-9173, 1545-7885
On-line přístup:Získat plný text
Tagy: Přidat tag
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Abstract Epithelial-to-mesenchymal transition (EMT), a biological phenomenon of cellular plasticity initially reported in embryonic development, has been increasingly recognized for its importance in cancer progression and metastasis. Despite tremendous progress being made in the past 2 decades in our understanding of the molecular mechanism and functional importance of EMT in cancer, there are several mysteries around EMT that remain unresolved. In this Unsolved Mystery, we focus on the variety of EMT types in metastasis, cooperative and collective EMT behaviors, spatiotemporal characterization of EMT, and strategies of therapeutically targeting EMT. We also highlight new technical advances that will facilitate the efforts to elucidate the unsolved mysteries of EMT in metastasis.
AbstractList Epithelial-to-mesenchymal transition (EMT), a biological phenomenon of cellular plasticity initially reported in embryonic development, has been increasingly recognized for its importance in cancer progression and metastasis. Despite tremendous progress being made in the past 2 decades in our understanding of the molecular mechanism and functional importance of EMT in cancer, there are several mysteries around EMT that remain unresolved. In this Unsolved Mystery, we focus on the variety of EMT types in metastasis, cooperative and collective EMT behaviors, spatiotemporal characterization of EMT, and strategies of therapeutically targeting EMT. We also highlight new technical advances that will facilitate the efforts to elucidate the unsolved mysteries of EMT in metastasis.
Epithelial-to-mesenchymal transition (EMT), a biological phenomenon of cellular plasticity initially reported in embryonic development, has been increasingly recognized for its importance in cancer progression and metastasis. Despite tremendous progress being made in the past 2 decades in our understanding of the molecular mechanism and functional importance of EMT in cancer, there are several mysteries around EMT that remain unresolved. In this Unsolved Mystery, we focus on the variety of EMT types in metastasis, cooperative and collective EMT behaviors, spatiotemporal characterization of EMT, and strategies of therapeutically targeting EMT. We also highlight new technical advances that will facilitate the efforts to elucidate the unsolved mysteries of EMT in metastasis. Epithelial-to-mesenchymal transition (EMT) promotes metastasis. This Unsolved Mystery looks at what is known about different types of EMT, the cooperative behaviors of tumor cells, and spatiotemporal aspects of EMT, and what potential they could hold for developing new therapeutic avenues.
Epithelial-to-mesenchymal transition (EMT), a biological phenomenon of cellular plasticity initially reported in embryonic development, has been increasingly recognized for its importance in cancer progression and metastasis. Despite tremendous progress being made in the past 2 decades in our understanding of the molecular mechanism and functional importance of EMT in cancer, there are several mysteries around EMT that remain unresolved. In this Unsolved Mystery, we focus on the variety of EMT types in metastasis, cooperative and collective EMT behaviors, spatiotemporal characterization of EMT, and strategies of therapeutically targeting EMT. We also highlight new technical advances that will facilitate the efforts to elucidate the unsolved mysteries of EMT in metastasis.Epithelial-to-mesenchymal transition (EMT), a biological phenomenon of cellular plasticity initially reported in embryonic development, has been increasingly recognized for its importance in cancer progression and metastasis. Despite tremendous progress being made in the past 2 decades in our understanding of the molecular mechanism and functional importance of EMT in cancer, there are several mysteries around EMT that remain unresolved. In this Unsolved Mystery, we focus on the variety of EMT types in metastasis, cooperative and collective EMT behaviors, spatiotemporal characterization of EMT, and strategies of therapeutically targeting EMT. We also highlight new technical advances that will facilitate the efforts to elucidate the unsolved mysteries of EMT in metastasis.
Audience Academic
Author Celià-Terrassa, Toni
Kang, Yibin
AuthorAffiliation 3 Ludwig Institute for Cancer Research Princeton Branch, Princeton, New Jersey, United States of America
1 Cancer Research Program, Hospital del Mar Research Institute, Barcelona, Spain
2 Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America
AuthorAffiliation_xml – name: 1 Cancer Research Program, Hospital del Mar Research Institute, Barcelona, Spain
– name: 2 Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America
– name: 3 Ludwig Institute for Cancer Research Princeton Branch, Princeton, New Jersey, United States of America
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  givenname: Toni
  surname: Celià-Terrassa
  fullname: Celià-Terrassa, Toni
– sequence: 2
  givenname: Yibin
  orcidid: 0000-0002-1626-6730
  surname: Kang
  fullname: Kang, Yibin
BackLink https://www.ncbi.nlm.nih.gov/pubmed/38324529$$D View this record in MEDLINE/PubMed
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Copyright Copyright: © 2024 Celià-Terrassa, Kang. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
COPYRIGHT 2024 Public Library of Science
2024 Celià-Terrassa, Kang. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2024 Celià-Terrassa, Kang 2024 Celià-Terrassa, Kang
2024 Celià-Terrassa, Kang. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: Copyright: © 2024 Celià-Terrassa, Kang. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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– notice: 2024 Celià-Terrassa, Kang. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: 2024 Celià-Terrassa, Kang 2024 Celià-Terrassa, Kang
– notice: 2024 Celià-Terrassa, Kang. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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License Copyright: © 2024 Celià-Terrassa, Kang. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Y.K. is a founder and shareholder of KayoThera Inc. and Firebrand Therapeutics Inc.
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PublicationDate 20240207
PublicationDateYYYYMMDD 2024-02-07
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PublicationTitle PLoS biology
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Snippet Epithelial-to-mesenchymal transition (EMT), a biological phenomenon of cellular plasticity initially reported in embryonic development, has been increasingly...
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StartPage e3002487
SubjectTerms Analysis
Breast cancer
Cancer
Colorectal cancer
Embryogenesis
Embryonic development
Embryonic growth stage
Medical research
Medicine and Health Sciences
Metastases
Metastasis
Methods
Molecular modelling
Plastic foam
Stem cells
Transcription factors
Tumors
Unsolved Mystery
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Title How important is EMT for cancer metastasis?
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http://dx.doi.org/10.1371/journal.pbio.3002487
Volume 22
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