How important is EMT for cancer metastasis?

Epithelial-to-mesenchymal transition (EMT), a biological phenomenon of cellular plasticity initially reported in embryonic development, has been increasingly recognized for its importance in cancer progression and metastasis. Despite tremendous progress being made in the past 2 decades in our unders...

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Bibliographic Details
Published in:PLoS biology Vol. 22; no. 2; p. e3002487
Main Authors: Celià-Terrassa, Toni, Kang, Yibin
Format: Journal Article
Language:English
Published: United States Public Library of Science 07.02.2024
Public Library of Science (PLoS)
Subjects:
Analysis
Breast cancer
Cancer
Colorectal cancer
Embryogenesis
Embryonic development
Embryonic growth stage
Medical research
Medicine and Health Sciences
Metastases
Metastasis
Methods
Molecular modelling
Plastic foam
Stem cells
Transcription factors
Tumors
Unsolved Mystery
United States
ISSN:1545-7885, 1544-9173, 1545-7885
Online Access:Get full text
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Summary:Epithelial-to-mesenchymal transition (EMT), a biological phenomenon of cellular plasticity initially reported in embryonic development, has been increasingly recognized for its importance in cancer progression and metastasis. Despite tremendous progress being made in the past 2 decades in our understanding of the molecular mechanism and functional importance of EMT in cancer, there are several mysteries around EMT that remain unresolved. In this Unsolved Mystery, we focus on the variety of EMT types in metastasis, cooperative and collective EMT behaviors, spatiotemporal characterization of EMT, and strategies of therapeutically targeting EMT. We also highlight new technical advances that will facilitate the efforts to elucidate the unsolved mysteries of EMT in metastasis.
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Y.K. is a founder and shareholder of KayoThera Inc. and Firebrand Therapeutics Inc.
ISSN:1545-7885
1544-9173
1545-7885
DOI:10.1371/journal.pbio.3002487