How important is EMT for cancer metastasis?

Epithelial-to-mesenchymal transition (EMT), a biological phenomenon of cellular plasticity initially reported in embryonic development, has been increasingly recognized for its importance in cancer progression and metastasis. Despite tremendous progress being made in the past 2 decades in our unders...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:PLoS biology Ročník 22; číslo 2; s. e3002487
Hlavní autoři: Celià-Terrassa, Toni, Kang, Yibin
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Public Library of Science 07.02.2024
Public Library of Science (PLoS)
Témata:
Analysis
Breast cancer
Cancer
Colorectal cancer
Embryogenesis
Embryonic development
Embryonic growth stage
Medical research
Medicine and Health Sciences
Metastases
Metastasis
Methods
Molecular modelling
Plastic foam
Stem cells
Transcription factors
Tumors
Unsolved Mystery
United States
ISSN:1545-7885, 1544-9173, 1545-7885
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Abstract Epithelial-to-mesenchymal transition (EMT), a biological phenomenon of cellular plasticity initially reported in embryonic development, has been increasingly recognized for its importance in cancer progression and metastasis. Despite tremendous progress being made in the past 2 decades in our understanding of the molecular mechanism and functional importance of EMT in cancer, there are several mysteries around EMT that remain unresolved. In this Unsolved Mystery, we focus on the variety of EMT types in metastasis, cooperative and collective EMT behaviors, spatiotemporal characterization of EMT, and strategies of therapeutically targeting EMT. We also highlight new technical advances that will facilitate the efforts to elucidate the unsolved mysteries of EMT in metastasis.
AbstractList Epithelial-to-mesenchymal transition (EMT), a biological phenomenon of cellular plasticity initially reported in embryonic development, has been increasingly recognized for its importance in cancer progression and metastasis. Despite tremendous progress being made in the past 2 decades in our understanding of the molecular mechanism and functional importance of EMT in cancer, there are several mysteries around EMT that remain unresolved. In this Unsolved Mystery, we focus on the variety of EMT types in metastasis, cooperative and collective EMT behaviors, spatiotemporal characterization of EMT, and strategies of therapeutically targeting EMT. We also highlight new technical advances that will facilitate the efforts to elucidate the unsolved mysteries of EMT in metastasis.
Epithelial-to-mesenchymal transition (EMT), a biological phenomenon of cellular plasticity initially reported in embryonic development, has been increasingly recognized for its importance in cancer progression and metastasis. Despite tremendous progress being made in the past 2 decades in our understanding of the molecular mechanism and functional importance of EMT in cancer, there are several mysteries around EMT that remain unresolved. In this Unsolved Mystery, we focus on the variety of EMT types in metastasis, cooperative and collective EMT behaviors, spatiotemporal characterization of EMT, and strategies of therapeutically targeting EMT. We also highlight new technical advances that will facilitate the efforts to elucidate the unsolved mysteries of EMT in metastasis. Epithelial-to-mesenchymal transition (EMT) promotes metastasis. This Unsolved Mystery looks at what is known about different types of EMT, the cooperative behaviors of tumor cells, and spatiotemporal aspects of EMT, and what potential they could hold for developing new therapeutic avenues.
Epithelial-to-mesenchymal transition (EMT), a biological phenomenon of cellular plasticity initially reported in embryonic development, has been increasingly recognized for its importance in cancer progression and metastasis. Despite tremendous progress being made in the past 2 decades in our understanding of the molecular mechanism and functional importance of EMT in cancer, there are several mysteries around EMT that remain unresolved. In this Unsolved Mystery, we focus on the variety of EMT types in metastasis, cooperative and collective EMT behaviors, spatiotemporal characterization of EMT, and strategies of therapeutically targeting EMT. We also highlight new technical advances that will facilitate the efforts to elucidate the unsolved mysteries of EMT in metastasis.Epithelial-to-mesenchymal transition (EMT), a biological phenomenon of cellular plasticity initially reported in embryonic development, has been increasingly recognized for its importance in cancer progression and metastasis. Despite tremendous progress being made in the past 2 decades in our understanding of the molecular mechanism and functional importance of EMT in cancer, there are several mysteries around EMT that remain unresolved. In this Unsolved Mystery, we focus on the variety of EMT types in metastasis, cooperative and collective EMT behaviors, spatiotemporal characterization of EMT, and strategies of therapeutically targeting EMT. We also highlight new technical advances that will facilitate the efforts to elucidate the unsolved mysteries of EMT in metastasis.
Audience Academic
Author Celià-Terrassa, Toni
Kang, Yibin
AuthorAffiliation 3 Ludwig Institute for Cancer Research Princeton Branch, Princeton, New Jersey, United States of America
1 Cancer Research Program, Hospital del Mar Research Institute, Barcelona, Spain
2 Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America
AuthorAffiliation_xml – name: 1 Cancer Research Program, Hospital del Mar Research Institute, Barcelona, Spain
– name: 2 Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America
– name: 3 Ludwig Institute for Cancer Research Princeton Branch, Princeton, New Jersey, United States of America
Author_xml – sequence: 1
  givenname: Toni
  surname: Celià-Terrassa
  fullname: Celià-Terrassa, Toni
– sequence: 2
  givenname: Yibin
  orcidid: 0000-0002-1626-6730
  surname: Kang
  fullname: Kang, Yibin
BackLink https://www.ncbi.nlm.nih.gov/pubmed/38324529$$D View this record in MEDLINE/PubMed
BookMark eNqVkm1r1EAUhYNU7Iv-A9GAXxTZNZmXZMYvpZRqF6oFrX4d7szerLMkmXVmou2_d9bNSrcUURLIMHnOudzDOcz2etdjlj0ti2lJ6_LN0g2-h3a60tZNaVEQJuoH2UHJGZ_UQvC9W-f97DCEZWKIJOJRtk8FJYwTeZC9Pnc_c9utnI_Qx9yG_OzDVd44nxvoDfq8wwghvTYcP84eNtAGfDJ-j7Iv786uTs8nF5fvZ6cnFxNTySpOJIfGVGAMAJVFUzcctCCECCo1E0JTXTGqaw2yQt1AhYagQImMMi6BEXqUPd_4rloX1LhnULSoZFmndVgiZhti7mCpVt524G-UA6t-Xzi_UOCjNS0qrZGaEkUzlwUrEIALVsl6TistqCh48joepw26w7nBPnpod0x3__T2m1q4H6osBJOEi-TwcnTw7vuAIarOBoNtCz26IagUOpVlGiYT-uIOev96I7WAtIHtG5cGm7WpOqkFF3VN-dpreg-Vnjl21qSyNDbd7whe7QgSE_E6LmAIQc0-f_oP9uO_s5dfd9lnt9P-E_O2kQl4uwGMdyF4bJSxEaJ16_Btm1JX6_pvc1Pr-qux_knM7oi3_n-V_QI9CAc6
CitedBy_id crossref_primary_10_1016_j_xfnr_2025_100089
crossref_primary_10_1021_acs_jproteome_5c00386
crossref_primary_10_1038_s41571_025_01058_2
crossref_primary_10_1038_s41540_024_00483_w
crossref_primary_10_3390_ijms25179277
crossref_primary_10_1186_s12943_025_02338_2
crossref_primary_10_1016_j_isci_2025_112551
crossref_primary_10_1016_j_canlet_2024_216769
crossref_primary_10_3390_cells14080585
crossref_primary_10_3390_cells14191484
crossref_primary_10_1158_0008_5472_CAN_24_2801
crossref_primary_10_1158_0008_5472_CAN_24_4309
crossref_primary_10_3389_fphar_2025_1585668
crossref_primary_10_3390_biomedicines12081801
crossref_primary_10_1007_s00210_025_04235_3
crossref_primary_10_1091_mbc_E25_07_0340
crossref_primary_10_1016_j_canlet_2025_218032
crossref_primary_10_1016_j_ccell_2025_06_015
crossref_primary_10_2174_0115665240310780240805114133
crossref_primary_10_3389_fonc_2025_1471110
crossref_primary_10_3390_ijms25179669
crossref_primary_10_1186_s12943_025_02342_6
crossref_primary_10_1016_j_jbc_2024_107994
crossref_primary_10_37349_edd_2025_100588
crossref_primary_10_1016_j_lfs_2024_122972
crossref_primary_10_1016_j_biopha_2025_117880
crossref_primary_10_1038_s41416_025_03074_6
crossref_primary_10_3390_jcm13174995
crossref_primary_10_3390_cancers17020290
crossref_primary_10_1038_s44341_024_00007_x
crossref_primary_10_17816_aog677746
crossref_primary_10_1038_s41388_025_03360_w
crossref_primary_10_1016_j_drup_2024_101119
crossref_primary_10_21053_ceo_2025_00029
crossref_primary_10_3390_cancers16172975
crossref_primary_10_3390_vetsci11120652
crossref_primary_10_1007_s42452_024_06218_0
crossref_primary_10_1093_bib_bbaf415
crossref_primary_10_1016_j_drup_2025_101276
crossref_primary_10_1016_j_fitote_2025_106774
crossref_primary_10_1007_s00210_025_03861_1
crossref_primary_10_1016_j_cellsig_2025_111634
crossref_primary_10_3390_ijms25137234
crossref_primary_10_1097_CAD_0000000000001744
Cites_doi 10.1038/nature15748
10.1038/s41580-020-0237-9
10.1074/jbc.M005912200
10.1016/j.stem.2016.10.018
10.1016/j.ccr.2012.09.022
10.1038/s41467-020-18951-2
10.1016/j.cell.2009.11.007
10.1126/science.aaf6546
10.1038/nature15260
10.1038/s41467-019-13091-8
10.1016/j.biosystems.2016.05.009
10.1016/j.cell.2017.12.007
10.1016/j.tcb.2018.12.001
10.1038/nm.2401
10.1016/j.ccr.2012.10.012
10.1158/0008-5472.CAN-15-2662
10.4161/19336918.2014.972761
10.1016/j.ccell.2018.12.002
10.1016/j.cell.2016.06.028
10.1038/ncb2765
10.1038/nrc3971
10.1172/JCI77767
10.1093/annonc/mdz244.001
10.1016/j.tcb.2021.10.004
10.1073/pnas.1812876116
10.1016/j.cell.2008.09.043
10.1016/j.cell.2014.07.013
10.1016/j.ccell.2019.12.003
10.1172/JCI20074
10.3389/fonc.2014.00371
10.1016/j.cell.2008.03.027
10.1530/ERC-15-0383
10.1016/j.ccell.2021.05.005
10.1007/s10585-008-9177-z
10.1016/j.ccr.2011.09.009
10.1038/nature16064
10.1038/s41556-022-01045-0
10.1016/j.cell.2017.10.044
10.1016/j.celrep.2016.02.034
10.1016/j.cell.2011.11.025
10.7554/eLife.84019
10.1038/s41576-023-00601-0
10.1016/j.ccr.2009.01.023
10.1016/j.ceb.2021.01.001
10.1073/pnas.1110431108
10.3389/fonc.2020.553342
10.1038/nature20609
10.1016/j.cell.2022.12.028
10.1016/j.devcel.2020.06.021
10.1038/s41556-019-0309-2
10.1126/science.1228522
10.1038/s41467-018-07538-7
10.1016/j.celrep.2019.09.081
10.1038/s41568-021-00332-6
10.1038/ncb3513
10.1038/35000034
10.1016/j.ccell.2019.02.010
10.1038/s41388-018-0488-5
10.3390/jcm8050646
10.1158/2159-8290.CD-21-0282
10.1093/intbio/zyz021
10.1038/nature22816
10.1016/j.cell.2022.04.015
10.1158/1078-0432.CCR-15-0876
10.1038/nature13556
10.1126/scitranslmed.abn7571
10.1007/s10911-010-9178-9
10.1016/j.devcel.2022.11.015
10.1038/s41598-018-21061-1
10.1073/pnas.171610498
10.1007/s00418-008-0529-1
10.1016/j.cell.2009.06.034
10.1242/dev.159525
10.1172/JCI59218
10.1186/s13058-020-01304-8
10.1038/s41586-023-06367-z
10.1038/s41586-018-0040-3
10.1038/ncomms15166
10.1073/pnas.1318192110
10.1007/s00018-011-0735-1
10.1038/ncb1973
10.1038/nrclinonc.2017.44
10.1186/s12943-022-01569-x
10.1038/s41586-023-06372-2
10.1038/s41588-019-0489-5
10.1038/s41586-023-05729-x
10.1038/s41467-019-08595-2
10.1038/35000025
10.1073/pnas.1004900107
10.1016/j.jtbi.2009.10.002
10.1016/j.devcel.2019.04.010
10.1016/j.devcel.2018.05.027
10.1038/s41586-020-03046-1
10.1038/s41467-019-10269-y
10.15252/emmm.201404208
10.1016/j.devcel.2021.11.006
10.1016/j.cell.2013.11.029
10.1038/s41556-018-0109-0
10.1038/s43018-020-0068-9
10.1158/0008-5472.CAN-07-2318
10.1038/nrmicro.2016.89
10.1158/1078-0432.CCR-12-1558
ContentType Journal Article
Copyright Copyright: © 2024 Celià-Terrassa, Kang. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
COPYRIGHT 2024 Public Library of Science
2024 Celià-Terrassa, Kang. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2024 Celià-Terrassa, Kang 2024 Celià-Terrassa, Kang
2024 Celià-Terrassa, Kang. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: Copyright: © 2024 Celià-Terrassa, Kang. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
– notice: COPYRIGHT 2024 Public Library of Science
– notice: 2024 Celià-Terrassa, Kang. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: 2024 Celià-Terrassa, Kang 2024 Celià-Terrassa, Kang
– notice: 2024 Celià-Terrassa, Kang. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID AAYXX
CITATION
NPM
IOV
ISN
ISR
3V.
7QG
7QL
7SN
7SS
7T5
7TK
7TM
7X7
7XB
88E
8FD
8FE
8FH
8FI
8FJ
8FK
ABUWG
AEUYN
AFKRA
ATCPS
AZQEC
BBNVY
BENPR
BHPHI
C1K
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
LK8
M0S
M1P
M7N
M7P
P64
PATMY
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
PYCSY
RC3
7X8
5PM
DOA
CZG
DOI 10.1371/journal.pbio.3002487
DatabaseName CrossRef
PubMed
Gale In Context: Opposing Viewpoints
Gale In Context: Canada
Gale In Context: Science
ProQuest Central (Corporate)
Animal Behavior Abstracts
Bacteriology Abstracts (Microbiology B)
Ecology Abstracts
Entomology Abstracts (Full archive)
Immunology Abstracts
Neurosciences Abstracts
Nucleic Acids Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Technology Research Database
ProQuest SciTech Collection
ProQuest Natural Science Collection
ProQuest Hospital Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest One Sustainability
ProQuest Central UK/Ireland
Agricultural & Environmental Science Collection
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One
ProQuest Central
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
ProQuest Health & Medical Collection
PML(ProQuest Medical Library)
Algology Mycology and Protozoology Abstracts (Microbiology C)
Biological Science Database
Biotechnology and BioEngineering Abstracts
Environmental Science Database
ProQuest Central Premium
ProQuest One Academic
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic (retired)
ProQuest One Academic UKI Edition
ProQuest Central China
Environmental Science Collection
Genetics Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
PLoS Biology
DatabaseTitle CrossRef
PubMed
Publicly Available Content Database
ProQuest Central Student
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
ProQuest Central China
Environmental Sciences and Pollution Management
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
Health Research Premium Collection
Natural Science Collection
Health & Medical Research Collection
Biological Science Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Ecology Abstracts
Neurosciences Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Environmental Science Collection
Entomology Abstracts
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Environmental Science Database
Engineering Research Database
ProQuest One Academic
ProQuest One Academic (New)
Technology Research Database
ProQuest One Academic Middle East (New)
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Central
ProQuest Health & Medical Research Collection
Genetics Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
Algology Mycology and Protozoology Abstracts (Microbiology C)
Agricultural & Environmental Science Collection
AIDS and Cancer Research Abstracts
ProQuest SciTech Collection
ProQuest Medical Library
Animal Behavior Abstracts
Immunology Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList Publicly Available Content Database


CrossRef
MEDLINE - Academic

PubMed
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: PIMPY
  name: Publicly Available Content Database
  url: http://search.proquest.com/publiccontent
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1545-7885
ExternalDocumentID 3069177884
oai_doaj_org_article_bbe3c1e8fd9040eaa584697d36b83805
PMC10849258
A785877359
38324529
10_1371_journal_pbio_3002487
Genre Journal Article
GeographicLocations United States
GeographicLocations_xml – name: United States
GrantInformation_xml – fundername: ;
– fundername: ;
  grantid: RP-19-180-01-CSM
– fundername: ;
  grantid: 20-0156
– fundername: ;
  grantid: MS17/00037 and PI21/00020
– fundername: ;
  grantid: SAC220223
– fundername: ;
  grantid: BCRF-22-082
GroupedDBID ---
123
29O
2WC
36B
53G
5VS
7X7
7XC
88E
8FE
8FH
8FI
8FJ
AAFWJ
AAUCC
AAWOE
AAYXX
ABDBF
ABIVO
ABUFD
ABUWG
ACCTH
ACGFO
ACIHN
ACPRK
ACUHS
ADBBV
AEAQA
AENEX
AEUYN
AFFHD
AFKRA
AFPKN
AFRAH
AFXKF
AHMBA
AKRSQ
ALMA_UNASSIGNED_HOLDINGS
AOIJS
ATCPS
B0M
BAIFH
BAWUL
BBNVY
BBTPI
BCNDV
BENPR
BHPHI
BPHCQ
BVXVI
BWKFM
CCPQU
CITATION
CS3
DIK
DU5
E3Z
EAD
EAP
EAS
EBD
EBS
EJD
EMB
EMK
EMOBN
EPL
ESX
F5P
FPL
FYUFA
GROUPED_DOAJ
GX1
HCIFZ
HMCUK
HYE
IAG
IAO
IGS
IHR
IOV
ISE
ISN
ISR
ITC
KQ8
LK8
M1P
M48
M7P
O5R
O5S
OK1
OVT
P2P
PATMY
PHGZM
PHGZT
PIMPY
PJZUB
PPXIY
PQGLB
PQQKQ
PROAC
PSQYO
PV9
PYCSY
QF4
QN7
RNS
RPM
RZL
SJN
SV3
TR2
TUS
UKHRP
WOW
XSB
YZZ
~8M
.GJ
ADRAZ
ADXHL
ALIPV
C1A
IPNFZ
NPM
RIG
WOQ
3V.
7QG
7QL
7SN
7SS
7T5
7TK
7TM
7XB
8FD
8FK
AZQEC
C1K
DWQXO
FR3
GNUQQ
H94
K9.
M7N
P64
PKEHL
PQEST
PQUKI
PRINS
RC3
7X8
PUEGO
5PM
CZG
ID FETCH-LOGICAL-c696t-95afc6accaa390f7f5ab8222839b488b3b643b7ba96ebfa6ec2e8e9e43459a423
IEDL.DBID FPL
ISICitedReferencesCount 54
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001163891900001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 1545-7885
1544-9173
IngestDate Tue Aug 12 00:51:29 EDT 2025
Tue Oct 14 19:08:55 EDT 2025
Tue Nov 04 02:05:55 EST 2025
Thu Sep 04 17:02:47 EDT 2025
Tue Oct 07 06:36:25 EDT 2025
Tue Nov 11 10:54:17 EST 2025
Tue Nov 04 18:14:06 EST 2025
Thu Nov 13 16:12:42 EST 2025
Thu Nov 13 16:12:01 EST 2025
Thu Nov 13 16:12:46 EST 2025
Mon Jul 21 06:00:33 EDT 2025
Tue Nov 18 22:17:27 EST 2025
Sat Nov 29 03:28:11 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 2
Language English
License Copyright: © 2024 Celià-Terrassa, Kang. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Creative Commons Attribution License
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c696t-95afc6accaa390f7f5ab8222839b488b3b643b7ba96ebfa6ec2e8e9e43459a423
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
Y.K. is a founder and shareholder of KayoThera Inc. and Firebrand Therapeutics Inc.
ORCID 0000-0002-1626-6730
OpenAccessLink http://dx.doi.org/10.1371/journal.pbio.3002487
PMID 38324529
PQID 3069177884
PQPubID 1436341
ParticipantIDs plos_journals_3069177884
doaj_primary_oai_doaj_org_article_bbe3c1e8fd9040eaa584697d36b83805
pubmedcentral_primary_oai_pubmedcentral_nih_gov_10849258
proquest_miscellaneous_2923913809
proquest_journals_3069177884
gale_infotracmisc_A785877359
gale_infotracacademiconefile_A785877359
gale_incontextgauss_ISR_A785877359
gale_incontextgauss_ISN_A785877359
gale_incontextgauss_IOV_A785877359
pubmed_primary_38324529
crossref_citationtrail_10_1371_journal_pbio_3002487
crossref_primary_10_1371_journal_pbio_3002487
PublicationCentury 2000
PublicationDate 20240207
PublicationDateYYYYMMDD 2024-02-07
PublicationDate_xml – month: 2
  year: 2024
  text: 20240207
  day: 7
PublicationDecade 2020
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: San Francisco
– name: San Francisco, CA USA
PublicationTitle PLoS biology
PublicationTitleAlternate PLoS Biol
PublicationYear 2024
Publisher Public Library of Science
Public Library of Science (PLoS)
Publisher_xml – name: Public Library of Science
– name: Public Library of Science (PLoS)
References D Yang (pbio.3002487.ref047) 2022; 185
X Zheng (pbio.3002487.ref006) 2015; 527
D Neelakantan (pbio.3002487.ref074) 2015; 9
Y Li (pbio.3002487.ref010) 2020; 54
K Papenfort (pbio.3002487.ref088) 2016; 14
T Shibue (pbio.3002487.ref092) 2017; 14
LA Byers (pbio.3002487.ref097) 2013; 19
F Bocci (pbio.3002487.ref051) 2019; 11
AD Rhim (pbio.3002487.ref017) 2012; 148
JM Westcott (pbio.3002487.ref063) 2015; 125
AW Lambert (pbio.3002487.ref013) 2021; 21
F Lüönd (pbio.3002487.ref011) 2021; 56
OH Ocaña (pbio.3002487.ref040) 2012; 22
T Celià-Terrassa (pbio.3002487.ref028) 2018; 9
I Pastushenko (pbio.3002487.ref053) 2021; 589
I Pastushenko (pbio.3002487.ref012) 2018; 556
J Hickson (pbio.3002487.ref089) 2009; 26
E Batlle (pbio.3002487.ref002) 2000; 2
J Haerinck (pbio.3002487.ref056) 2023; 24
TZ Tan (pbio.3002487.ref093) 2014; 6
W Lu (pbio.3002487.ref004) 2019; 49
A Satelli (pbio.3002487.ref099) 2011; 68
DP Tabassum (pbio.3002487.ref073) 2015; 15
V Sanz-Moreno (pbio.3002487.ref035) 2008; 135
AC Rios (pbio.3002487.ref070) 2019; 35
A Martinez Arias (pbio.3002487.ref079) 2018; 145
M Labelle (pbio.3002487.ref091) 2011; 20
Z Zhang (pbio.3002487.ref085) 2016; 146
C Kröger (pbio.3002487.ref048) 2019; 116
M Korpal (pbio.3002487.ref039) 2011; 17
HC Lo (pbio.3002487.ref076) 2020; 1
AK Casasent (pbio.3002487.ref067) 2018; 172
KR Fischer (pbio.3002487.ref005) 2015; 527
T Revenco (pbio.3002487.ref042) 2019; 29
M Latil (pbio.3002487.ref024) 2017; 20
D Olmeda (pbio.3002487.ref021) 2007; 67
KP Simeonov (pbio.3002487.ref029) 2021; 39
K Campbell (pbio.3002487.ref064) 2019; 10
NM Aiello (pbio.3002487.ref025) 2018; 45
DS Micalizzi (pbio.3002487.ref080) 2010; 15
JL McFaline-Figueroa (pbio.3002487.ref031) 2019; 51
SV Puram (pbio.3002487.ref052) 2017; 171
J Cui (pbio.3002487.ref054) 2023; 25
J Berenguer (pbio.3002487.ref057) 2021; 69
P Cassier (pbio.3002487.ref102) 2019; 30
Z Zhao (pbio.3002487.ref081) 2016; 76
MP Mak (pbio.3002487.ref095) 2016; 22
GM Tagliazucchi (pbio.3002487.ref094) 2022
S Rafehi (pbio.3002487.ref105) 2016; 23
A Francou (pbio.3002487.ref078) 2023; 12
C Kudo-Saito (pbio.3002487.ref020) 2009; 15
A Marusyk (pbio.3002487.ref072) 2014; 514
JH Taube (pbio.3002487.ref026) 2010; 107
JP Thiery (pbio.3002487.ref077) 2009; 139
H Fazilaty (pbio.3002487.ref027) 2019; 10
A Emad (pbio.3002487.ref069) 2020; 22
M Esposito (pbio.3002487.ref046) 2019; 21
M Al Bakir (pbio.3002487.ref015) 2023; 616
I Pastushenko (pbio.3002487.ref014) 2019; 29
D Merino (pbio.3002487.ref075) 2019; 10
T Brabletz (pbio.3002487.ref090) 2001; 98
KJ Cheung (pbio.3002487.ref065) 2013; 155
M Hentzer (pbio.3002487.ref087) 2003; 112
AR Subbalakshmi (pbio.3002487.ref050) 2020; 10
PB Gupta (pbio.3002487.ref103) 2009; 138
I Rodriguez-Hernandez (pbio.3002487.ref033) 2020; 11
X Liu (pbio.3002487.ref043) 2013; 15
JR Lin (pbio.3002487.ref066) 2023; 186
N Aceto (pbio.3002487.ref062) 2014; 158
NT Georgopoulos (pbio.3002487.ref086) 2014; 127
X Ye (pbio.3002487.ref008) 2017; 547
J Lengrand (pbio.3002487.ref101) 2023; 620
M Yu (pbio.3002487.ref068) 2013; 339
V Graziani (pbio.3002487.ref032) 2022; 32
D Ishay-Ronen (pbio.3002487.ref030) 2019; 35
AM Krebs (pbio.3002487.ref007) 2017; 19
M Lu (pbio.3002487.ref009) 2013; 110
YK Chae (pbio.3002487.ref096) 2018; 8
MA Nieto (pbio.3002487.ref001) 2016; 166
A Cano (pbio.3002487.ref003) 2000; 2
T Celià-Terrassa (pbio.3002487.ref038) 2012; 122
N Stylianou (pbio.3002487.ref045) 2018; 38
D Peng (pbio.3002487.ref098) 2022; 21
S Alexander (pbio.3002487.ref061) 2008; 130
AV Bakin (pbio.3002487.ref036) 2000; 275
JH Tsai (pbio.3002487.ref041) 2012; 22
SA Mani (pbio.3002487.ref019) 2008; 133
J Yang (pbio.3002487.ref022) 2020; 21
MQ Reeves (pbio.3002487.ref071) 2018; 20
Q Li (pbio.3002487.ref044) 2017; 8
AS Ribeiro (pbio.3002487.ref049) 2015; 4
JL Orgaz (pbio.3002487.ref034) 2020; 37
KL Harper (pbio.3002487.ref016) 2016; 540
GW Pearson (pbio.3002487.ref059) 2019; 8
AW Lambert (pbio.3002487.ref055) 2022; 57
E Beerling (pbio.3002487.ref082) 2016; 14
PA Cassier (pbio.3002487.ref100) 2023; 620
D Lu (pbio.3002487.ref104) 2011; 108
Y Hegerfeldt (pbio.3002487.ref060) 2002; 62
DA Lawson (pbio.3002487.ref018) 2015; 526
EM Grasset (pbio.3002487.ref023) 2022; 14
DC Walker (pbio.3002487.ref084) 2010; 262
DB Burkhardt (pbio.3002487.ref037) 2022; 12
KJ Cheung (pbio.3002487.ref058) 2016; 352
S Giampieri (pbio.3002487.ref083) 2009; 11
References_xml – volume: 527
  start-page: 472
  year: 2015
  ident: pbio.3002487.ref005
  article-title: Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance
  publication-title: Nature
  doi: 10.1038/nature15748
– volume: 21
  start-page: 341
  year: 2020
  ident: pbio.3002487.ref022
  article-title: Guidelines and definitions for research on epithelial–mesenchymal transition
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/s41580-020-0237-9
– volume: 275
  start-page: 36803
  year: 2000
  ident: pbio.3002487.ref036
  article-title: Phosphatidylinositol 3-Kinase Function Is Required for Transforming Growth Factor β-mediated Epithelial to Mesenchymal Transition and Cell Migration
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M005912200
– volume: 20
  start-page: 191
  year: 2017
  ident: pbio.3002487.ref024
  article-title: Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition.
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2016.10.018
– volume: 22
  start-page: 725
  year: 2012
  ident: pbio.3002487.ref041
  article-title: Spatiotemporal Regulation of Epithelial-Mesenchymal Transition Is Essential for Squamous Cell Carcinoma Metastasis
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2012.09.022
– volume: 11
  start-page: 5315
  year: 2020
  ident: pbio.3002487.ref033
  article-title: WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion.
  publication-title: Nat Commun
  doi: 10.1038/s41467-020-18951-2
– volume: 139
  start-page: 871
  year: 2009
  ident: pbio.3002487.ref077
  article-title: Epithelial-Mesenchymal Transitions in Development and Disease
  publication-title: Cell
  doi: 10.1016/j.cell.2009.11.007
– volume: 352
  start-page: 167
  year: 2016
  ident: pbio.3002487.ref058
  article-title: A collective route to metastasis: Seeding by tumor cell clusters
  publication-title: Science
  doi: 10.1126/science.aaf6546
– volume: 526
  start-page: 131
  year: 2015
  ident: pbio.3002487.ref018
  article-title: Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells
  publication-title: Nature
  doi: 10.1038/nature15260
– volume: 10
  start-page: 5115
  year: 2019
  ident: pbio.3002487.ref027
  article-title: A gene regulatory network to control EMT programs in development and disease
  publication-title: Nat Commun
  doi: 10.1038/s41467-019-13091-8
– volume: 146
  start-page: 110
  year: 2016
  ident: pbio.3002487.ref085
  article-title: Characterization and classification of adherent cells in monolayer culture using automated tracking and evolutionary algorithms.
  publication-title: BioSystems
  doi: 10.1016/j.biosystems.2016.05.009
– volume: 172
  start-page: 205
  year: 2018
  ident: pbio.3002487.ref067
  article-title: Multiclonal Invasion in Breast Tumors Identified by Topographic Single Cell Sequencing
  publication-title: Cell
  doi: 10.1016/j.cell.2017.12.007
– volume: 29
  start-page: 212
  year: 2019
  ident: pbio.3002487.ref014
  article-title: EMT Transition States during Tumor Progression and Metastasis
  publication-title: Trends Cell Biol
  doi: 10.1016/j.tcb.2018.12.001
– volume: 17
  start-page: 1101
  year: 2011
  ident: pbio.3002487.ref039
  article-title: Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization
  publication-title: Nat Med
  doi: 10.1038/nm.2401
– volume: 22
  start-page: 709
  year: 2012
  ident: pbio.3002487.ref040
  article-title: Metastatic Colonization Requires the Repression of the Epithelial-Mesenchymal Transition Inducer Prrx1
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2012.10.012
– volume: 76
  start-page: 2094
  year: 2016
  ident: pbio.3002487.ref081
  article-title: In Vivo Visualization and Characterization of Epithelial-Mesenchymal Transition in Breast Tumors
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-15-2662
– volume: 9
  start-page: 265
  year: 2015
  ident: pbio.3002487.ref074
  article-title: Intratumoral heterogeneity: Clonal cooperation in epithelial-to-mesenchymal transition and metastasis
  publication-title: Cell Adhes Migr
  doi: 10.4161/19336918.2014.972761
– volume: 35
  start-page: 17
  year: 2019
  ident: pbio.3002487.ref030
  article-title: Gain Fat—Lose Metastasis: Converting Invasive Breast Cancer Cells into Adipocytes Inhibits Cancer Metastasis
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2018.12.002
– volume: 166
  start-page: 21
  year: 2016
  ident: pbio.3002487.ref001
  article-title: EMT: 2016.
  publication-title: Cell
  doi: 10.1016/j.cell.2016.06.028
– volume: 15
  start-page: 829
  year: 2013
  ident: pbio.3002487.ref043
  article-title: Sequential introduction of reprogramming factors reveals a time-sensitive requirement for individual factors and a sequential EMT-MET mechanism for optimal reprogramming
  publication-title: Nat Cell Biol
  doi: 10.1038/ncb2765
– volume: 15
  start-page: 473
  year: 2015
  ident: pbio.3002487.ref073
  article-title: Tumorigenesis: It takes a village
  publication-title: Nat Rev Cancer
  doi: 10.1038/nrc3971
– volume: 125
  start-page: 1927
  year: 2015
  ident: pbio.3002487.ref063
  article-title: An epigenetically distinct breast cancer cell subpopulation promotes collective invasion
  publication-title: J Clin Invest
  doi: 10.1172/JCI77767
– volume: 30
  start-page: V159
  issue: Supp 5
  year: 2019
  ident: pbio.3002487.ref102
  article-title: A first in human, phase I trial of NP137, a first-in-class antibody targeting netrin-1, in patients with advanced refractory solid tumors [Abstract].
  publication-title: Ann Oncol.
  doi: 10.1093/annonc/mdz244.001
– volume: 32
  start-page: 228
  year: 2022
  ident: pbio.3002487.ref032
  article-title: The amoeboid state as part of the epithelial-to-mesenchymal transition programme
  publication-title: Trends Cell Biol
  doi: 10.1016/j.tcb.2021.10.004
– volume: 116
  start-page: 7353
  year: 2019
  ident: pbio.3002487.ref048
  article-title: Acquisition of a hybrid E/M state is essential for tumorigenicity of basal breast cancer cells
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1812876116
– volume: 135
  start-page: 510
  year: 2008
  ident: pbio.3002487.ref035
  article-title: Rac Activation and Inactivation Control Plasticity of Tumor Cell Movement
  publication-title: Cell
  doi: 10.1016/j.cell.2008.09.043
– volume: 158
  start-page: 1110
  year: 2014
  ident: pbio.3002487.ref062
  article-title: Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis
  publication-title: Cell
  doi: 10.1016/j.cell.2014.07.013
– volume: 37
  start-page: 85
  year: 2020
  ident: pbio.3002487.ref034
  article-title: Myosin II Reactivation and Cytoskeletal Remodeling as a Hallmark and a Vulnerability in Melanoma Therapy Resistance
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2019.12.003
– volume: 112
  start-page: 1300
  year: 2003
  ident: pbio.3002487.ref087
  article-title: Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections
  publication-title: J Clin Invest
  doi: 10.1172/JCI20074
– volume: 4
  start-page: 371
  year: 2015
  ident: pbio.3002487.ref049
  article-title: P-Cadherin Linking Breast Cancer Stem Cells and Invasion: A Promising Marker to Identify an “Intermediate/Metastable” EMT State.
  publication-title: Front Oncol.
  doi: 10.3389/fonc.2014.00371
– volume: 133
  start-page: 704
  year: 2008
  ident: pbio.3002487.ref019
  article-title: The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
  publication-title: Cell
  doi: 10.1016/j.cell.2008.03.027
– volume: 23
  start-page: 147
  year: 2016
  ident: pbio.3002487.ref105
  article-title: TGFβ signaling regulates epithelial–mesenchymal plasticity in ovarian cancer ascites-derived spheroids
  publication-title: Endocr Relat Cancer
  doi: 10.1530/ERC-15-0383
– volume: 39
  start-page: 1150
  year: 2021
  ident: pbio.3002487.ref029
  article-title: Single-cell lineage tracing of metastatic cancer reveals selection of hybrid EMT states
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2021.05.005
– volume: 26
  start-page: 67
  year: 2009
  ident: pbio.3002487.ref089
  article-title: Societal interactions in ovarian cancer metastasis: A quorum-sensing hypothesis
  publication-title: Clin Exp Metastasis
  doi: 10.1007/s10585-008-9177-z
– volume: 20
  start-page: 576
  year: 2011
  ident: pbio.3002487.ref091
  article-title: Direct Signaling between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2011.09.009
– volume: 527
  start-page: 525
  year: 2015
  ident: pbio.3002487.ref006
  article-title: Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer
  publication-title: Nature
  doi: 10.1038/nature16064
– volume: 25
  start-page: 145
  year: 2023
  ident: pbio.3002487.ref054
  article-title: MLL3 loss drives metastasis by promoting a hybrid epithelial–mesenchymal transition state
  publication-title: Nat Cell Biol
  doi: 10.1038/s41556-022-01045-0
– volume: 171
  start-page: 1611
  year: 2017
  ident: pbio.3002487.ref052
  article-title: Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer
  publication-title: Cell
  doi: 10.1016/j.cell.2017.10.044
– volume: 14
  start-page: 2281
  year: 2016
  ident: pbio.3002487.ref082
  article-title: Plasticity between Epithelial and Mesenchymal States Unlinks EMT from Metastasis-Enhancing Stem Cell Capacity
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2016.02.034
– volume: 148
  start-page: 349
  year: 2012
  ident: pbio.3002487.ref017
  article-title: EMT and Dissemination Precede Pancreatic Tumor Formation
  publication-title: Cell
  doi: 10.1016/j.cell.2011.11.025
– volume: 12
  start-page: e84019
  year: 2023
  ident: pbio.3002487.ref078
  article-title: A ratchet-like apical constriction drives cell ingression during the mouse gastrulation EMT
  publication-title: Elife
  doi: 10.7554/eLife.84019
– volume: 24
  start-page: 590
  year: 2023
  ident: pbio.3002487.ref056
  article-title: The landscape of epithelial-mesenchymal plasticity: principles of design and mechanisms of regulation
  publication-title: Nat Rev Genet
  doi: 10.1038/s41576-023-00601-0
– year: 2022
  ident: pbio.3002487.ref094
  article-title: Genomic and local microenvironment effects shaping epithelial-to-mesenchymal trajectories in cancer [preprint].
  publication-title: bioRxiv
– volume: 15
  start-page: 195
  year: 2009
  ident: pbio.3002487.ref020
  article-title: Cancer Metastasis Is Accelerated through Immunosuppression during Snail-Induced EMT of Cancer Cells
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2009.01.023
– volume: 69
  start-page: 103
  year: 2021
  ident: pbio.3002487.ref057
  article-title: Cell memory of epithelial-mesenchymal plasticity in cancer
  publication-title: Curr Opin Cell Biol
  doi: 10.1016/j.ceb.2021.01.001
– volume: 108
  start-page: 13253
  year: 2011
  ident: pbio.3002487.ref104
  article-title: Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1110431108
– volume: 10
  start-page: 553342
  year: 2020
  ident: pbio.3002487.ref050
  article-title: NFATc Acts as a Non-Canonical Phenotypic Stability Factor for a Hybrid Epithelial/Mesenchymal Phenotype.
  publication-title: Front Oncol.
  doi: 10.3389/fonc.2020.553342
– volume: 540
  start-page: 588
  year: 2016
  ident: pbio.3002487.ref016
  article-title: Mechanism of early dissemination and metastasis in Her2+mammary cancer
  publication-title: Nature
  doi: 10.1038/nature20609
– volume: 186
  start-page: 363
  year: 2023
  ident: pbio.3002487.ref066
  article-title: Multiplexed 3D atlas of state transitions and immune interaction in colorectal cancer
  publication-title: Cell
  doi: 10.1016/j.cell.2022.12.028
– volume: 54
  start-page: 593
  year: 2020
  ident: pbio.3002487.ref010
  article-title: Genetic Fate Mapping of Transient Cell Fate Reveals N-Cadherin Activity and Function in Tumor Metastasis
  publication-title: Dev Cell
  doi: 10.1016/j.devcel.2020.06.021
– volume: 21
  start-page: 627
  year: 2019
  ident: pbio.3002487.ref046
  article-title: Bone vascular niche E-selectin induces mesenchymal–epithelial transition and Wnt activation in cancer cells to promote bone metastasis
  publication-title: Nat Cell Biol
  doi: 10.1038/s41556-019-0309-2
– volume: 339
  start-page: 580
  year: 2013
  ident: pbio.3002487.ref068
  article-title: Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition
  publication-title: Science
  doi: 10.1126/science.1228522
– volume: 9
  start-page: 5005
  year: 2018
  ident: pbio.3002487.ref028
  article-title: Hysteresis control of epithelial-mesenchymal transition dynamics conveys a distinct program with enhanced metastatic ability.
  publication-title: Nat Commun
  doi: 10.1038/s41467-018-07538-7
– volume: 29
  start-page: 1458
  year: 2019
  ident: pbio.3002487.ref042
  article-title: Context Dependency of Epithelial-to-Mesenchymal Transition for Metastasis
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2019.09.081
– volume: 21
  start-page: 325
  year: 2021
  ident: pbio.3002487.ref013
  article-title: Linking EMT programmes to normal and neoplastic epithelial stem cells
  publication-title: Nat Rev Cancer
  doi: 10.1038/s41568-021-00332-6
– volume: 19
  start-page: 518
  year: 2017
  ident: pbio.3002487.ref007
  article-title: The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer
  publication-title: Nat Cell Biol
  doi: 10.1038/ncb3513
– volume: 2
  start-page: 84
  year: 2000
  ident: pbio.3002487.ref002
  article-title: The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells
  publication-title: Nat Cell Biol
  doi: 10.1038/35000034
– volume: 35
  start-page: 618
  year: 2019
  ident: pbio.3002487.ref070
  article-title: Intraclonal Plasticity in Mammary Tumors Revealed through Large-Scale Single-Cell Resolution 3D Imaging
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2019.02.010
– volume: 38
  start-page: 913
  year: 2018
  ident: pbio.3002487.ref045
  article-title: A molecular portrait of epithelial–mesenchymal plasticity in prostate cancer associated with clinical outcome
  publication-title: Oncogene
  doi: 10.1038/s41388-018-0488-5
– volume: 8
  start-page: 646
  year: 2019
  ident: pbio.3002487.ref059
  article-title: Control of Invasion by Epithelial-to-Mesenchymal Transition Programs during Metastasis.
  publication-title: J Clin Med.
  doi: 10.3390/jcm8050646
– volume: 12
  start-page: 1847
  year: 2022
  ident: pbio.3002487.ref037
  article-title: Mapping Phenotypic Plasticity upon the Cancer Cell State Landscape Using Manifold Learning.
  publication-title: Cancer Discov
  doi: 10.1158/2159-8290.CD-21-0282
– volume: 11
  start-page: 251
  year: 2019
  ident: pbio.3002487.ref051
  article-title: NRF2 activates a partial epithelial-mesenchymal transition and is maximally present in a hybrid epithelial/mesenchymal phenotype.
  publication-title: Integr Biol
  doi: 10.1093/intbio/zyz021
– volume: 547
  start-page: E1
  year: 2017
  ident: pbio.3002487.ref008
  article-title: Upholding a role for EMT in breast cancer metastasis
  publication-title: Nature
  doi: 10.1038/nature22816
– volume: 185
  start-page: 1905
  year: 2022
  ident: pbio.3002487.ref047
  article-title: Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution
  publication-title: Cell
  doi: 10.1016/j.cell.2022.04.015
– volume: 22
  start-page: 609
  year: 2016
  ident: pbio.3002487.ref095
  article-title: A Patient-Derived, Pan-Cancer EMT Signature Identifies Global Molecular Alterations and Immune Target Enrichment Following Epithelial-to-Mesenchymal Transition
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-15-0876
– volume: 514
  start-page: 54
  year: 2014
  ident: pbio.3002487.ref072
  article-title: Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity
  publication-title: Nature
  doi: 10.1038/nature13556
– volume: 14
  start-page: eabn7571
  year: 2022
  ident: pbio.3002487.ref023
  article-title: Triple-negative breast cancer metastasis involves complex epithelial-mesenchymal transition dynamics and requires vimentin
  publication-title: Sci Transl Med
  doi: 10.1126/scitranslmed.abn7571
– volume: 62
  start-page: 2125
  year: 2002
  ident: pbio.3002487.ref060
  article-title: Collective cell movement in primary melanoma explants: plasticity of cell-cell interaction, beta1-integrin function, and migration strategies
  publication-title: Cancer Res
– volume: 15
  start-page: 117
  year: 2010
  ident: pbio.3002487.ref080
  article-title: Epithelial-mesenchymal transition in cancer: Parallels between normal development and tumor progression
  publication-title: J Mammary Gland Biol Neoplasia
  doi: 10.1007/s10911-010-9178-9
– volume: 57
  start-page: 2714
  year: 2022
  ident: pbio.3002487.ref055
  article-title: ΔNp63/p73 drive metastatic colonization by controlling a regenerative epithelial stem cell program in quasi-mesenchymal cancer stem cells
  publication-title: Dev Cell
  doi: 10.1016/j.devcel.2022.11.015
– volume: 8
  start-page: 2918
  year: 2018
  ident: pbio.3002487.ref096
  article-title: Epithelial-mesenchymal transition (EMT) signature is inversely associated with T-cell infiltration in non-small cell lung cancer (NSCLC).
  publication-title: Sci Rep.
  doi: 10.1038/s41598-018-21061-1
– volume: 98
  start-page: 10356
  year: 2001
  ident: pbio.3002487.ref090
  article-title: Variable β-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.171610498
– volume: 130
  start-page: 1147
  year: 2008
  ident: pbio.3002487.ref061
  article-title: Dynamic imaging of cancer growth and invasion: a modified skin-fold chamber model
  publication-title: Histochem Cell Biol
  doi: 10.1007/s00418-008-0529-1
– volume: 138
  start-page: 645
  year: 2009
  ident: pbio.3002487.ref103
  article-title: Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening
  publication-title: Cell
  doi: 10.1016/j.cell.2009.06.034
– volume: 145
  start-page: dev159525
  year: 2018
  ident: pbio.3002487.ref079
  article-title: On the nature and function of organizers
  publication-title: Development
  doi: 10.1242/dev.159525
– volume: 122
  start-page: 1849
  year: 2012
  ident: pbio.3002487.ref038
  article-title: Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells
  publication-title: J Clin Invest
  doi: 10.1172/JCI59218
– volume: 22
  start-page: 74
  year: 2020
  ident: pbio.3002487.ref069
  article-title: Superior breast cancer metastasis risk stratification using an epithelial-mesenchymal-amoeboid transition gene signature
  publication-title: Breast Cancer Res
  doi: 10.1186/s13058-020-01304-8
– volume: 620
  start-page: 409
  year: 2023
  ident: pbio.3002487.ref100
  article-title: Netrin-1 blockade inhibits tumour growth and EMT features in endometrial cancer
  publication-title: Nature
  doi: 10.1038/s41586-023-06367-z
– volume: 556
  start-page: 463
  year: 2018
  ident: pbio.3002487.ref012
  article-title: Identification of the tumour transition states occurring during EMT
  publication-title: Nature
  doi: 10.1038/s41586-018-0040-3
– volume: 8
  start-page: 15166
  year: 2017
  ident: pbio.3002487.ref044
  article-title: A sequential EMT-MET mechanism drives the differentiation of human embryonic stem cells towards hepatocytes
  publication-title: Nat Commun
  doi: 10.1038/ncomms15166
– volume: 110
  start-page: 18144
  year: 2013
  ident: pbio.3002487.ref009
  article-title: MicroRNA-based regulation of epithelial-hybrid mesencymal fate determination
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1318192110
– volume: 68
  start-page: 3033
  year: 2011
  ident: pbio.3002487.ref099
  article-title: Vimentin in cancer and its potential as a molecular target for cancer therapy
  publication-title: Cell Mol Life Sci
  doi: 10.1007/s00018-011-0735-1
– volume: 11
  start-page: 1287
  year: 2009
  ident: pbio.3002487.ref083
  article-title: Localized and reversible TGFβ signalling switches breast cancer cells from cohesive to single cell motility
  publication-title: Nat Cell Biol
  doi: 10.1038/ncb1973
– volume: 14
  start-page: 611
  year: 2017
  ident: pbio.3002487.ref092
  article-title: EMT, CSCs, and drug resistance: the mechanistic link and clinical implications.
  publication-title: Nat Rev Clin Oncol
  doi: 10.1038/nrclinonc.2017.44
– volume: 21
  start-page: 104
  year: 2022
  ident: pbio.3002487.ref098
  article-title: Targeting TGF-β signal transduction for fibrosis and cancer therapy
  publication-title: Mol Cancer
  doi: 10.1186/s12943-022-01569-x
– volume: 620
  start-page: 402
  year: 2023
  ident: pbio.3002487.ref101
  article-title: Pharmacological targeting of netrin-1 inhibits EMT in cancer
  publication-title: Nature
  doi: 10.1038/s41586-023-06372-2
– volume: 51
  start-page: 1389
  year: 2019
  ident: pbio.3002487.ref031
  article-title: A pooled single-cell genetic screen identifies regulatory checkpoints in the continuum of the epithelial-to-mesenchymal transition
  publication-title: Nat Genet
  doi: 10.1038/s41588-019-0489-5
– volume: 616
  start-page: 534
  year: 2023
  ident: pbio.3002487.ref015
  article-title: The evolution of non-small cell lung cancer metastases in TRACERx
  publication-title: Nature
  doi: 10.1038/s41586-023-05729-x
– volume: 10
  start-page: 766
  year: 2019
  ident: pbio.3002487.ref075
  article-title: Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer
  publication-title: Nat Commun
  doi: 10.1038/s41467-019-08595-2
– volume: 2
  start-page: 76
  year: 2000
  ident: pbio.3002487.ref003
  article-title: The transcription factor Snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
  publication-title: Nat Cell Biol
  doi: 10.1038/35000025
– volume: 107
  start-page: 15449
  year: 2010
  ident: pbio.3002487.ref026
  article-title: Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1004900107
– volume: 262
  start-page: 425
  year: 2010
  ident: pbio.3002487.ref084
  article-title: Anti-social cells: Predicting the influence of E-cadherin loss on the growth of epithelial cell populations
  publication-title: J Theor Biol
  doi: 10.1016/j.jtbi.2009.10.002
– volume: 49
  start-page: 361
  year: 2019
  ident: pbio.3002487.ref004
  article-title: Epithelial-Mesenchymal Plasticity in Cancer Progression and Metastasis
  publication-title: Dev Cell
  doi: 10.1016/j.devcel.2019.04.010
– volume: 45
  start-page: 681
  year: 2018
  ident: pbio.3002487.ref025
  article-title: EMT Subtype Influences Epithelial Plasticity and Mode of Cell Migration
  publication-title: Dev Cell
  doi: 10.1016/j.devcel.2018.05.027
– volume: 589
  start-page: 448
  year: 2021
  ident: pbio.3002487.ref053
  article-title: Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis
  publication-title: Nature
  doi: 10.1038/s41586-020-03046-1
– volume: 10
  start-page: 2311
  year: 2019
  ident: pbio.3002487.ref064
  article-title: Collective cell migration and metastases induced by an epithelial-to-mesenchymal transition in Drosophila intestinal tumors
  publication-title: Nat Commun
  doi: 10.1038/s41467-019-10269-y
– volume: 127
  start-page: 2967
  year: 2014
  ident: pbio.3002487.ref086
  article-title: A novel bidirectional positive-feedback loop between Wnt-β-catenin and EGFR-ERK plays a role in context-specific modulation of epithelial tissue regeneration
  publication-title: J Cell Sci
– volume: 6
  start-page: 1279
  year: 2014
  ident: pbio.3002487.ref093
  article-title: Epithelial-mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients
  publication-title: EMBO Mol Med
  doi: 10.15252/emmm.201404208
– volume: 56
  start-page: 3203
  year: 2021
  ident: pbio.3002487.ref011
  article-title: Distinct contributions of partial and full EMT to breast cancer malignancy
  publication-title: Dev Cell
  doi: 10.1016/j.devcel.2021.11.006
– volume: 155
  start-page: 1639
  year: 2013
  ident: pbio.3002487.ref065
  article-title: Collective invasion in breast cancer requires a conserved basal epithelial program
  publication-title: Cell
  doi: 10.1016/j.cell.2013.11.029
– volume: 20
  start-page: 699
  year: 2018
  ident: pbio.3002487.ref071
  article-title: Multicolour lineage tracing reveals clonal dynamics of squamous carcinoma evolution from initiation to metastasis
  publication-title: Nat Cell Biol
  doi: 10.1038/s41556-018-0109-0
– volume: 1
  start-page: 709
  year: 2020
  ident: pbio.3002487.ref076
  article-title: Resistance to natural killer cell immunosurveillance confers a selective advantage to polyclonal metastasis
  publication-title: Nat Cancer
  doi: 10.1038/s43018-020-0068-9
– volume: 67
  start-page: 11721
  year: 2007
  ident: pbio.3002487.ref021
  article-title: SNAI1 Is Required for Tumor Growth and Lymph Node Metastasis of Human Breast Carcinoma MDA-MB-231
  publication-title: Cells. Cancer Res
  doi: 10.1158/0008-5472.CAN-07-2318
– volume: 14
  start-page: 576
  year: 2016
  ident: pbio.3002487.ref088
  article-title: Quorum sensing signal-response systems in Gram-negative bacteria
  publication-title: Nat Rev Microbiol
  doi: 10.1038/nrmicro.2016.89
– volume: 19
  start-page: 279
  year: 2013
  ident: pbio.3002487.ref097
  article-title: An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-12-1558
SSID ssj0022928
Score 2.6144707
Snippet Epithelial-to-mesenchymal transition (EMT), a biological phenomenon of cellular plasticity initially reported in embryonic development, has been increasingly...
SourceID plos
doaj
pubmedcentral
proquest
gale
pubmed
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage e3002487
SubjectTerms Analysis
Breast cancer
Cancer
Colorectal cancer
Embryogenesis
Embryonic development
Embryonic growth stage
Medical research
Medicine and Health Sciences
Metastases
Metastasis
Methods
Molecular modelling
Plastic foam
Stem cells
Transcription factors
Tumors
Unsolved Mystery
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3fb9QwDI7QCSReEL93MFBBSDygbtfLtUme0ECbxgMHgoH2FiWpC5W29nTpgfjvsdNctaKh8cBr40bqZzu2FfczYy9KUHSvaVKOCk4XGDNTg1EidYUFTD-czHIbhk2I5VKenqqPF0Z9UU9YTw_cA7dvLXCXgaxKhfYGxlDEVKLkhZVc9uylM6G2xVQsteYqTFUlqhl0Z8HjT3NcZPtRR3srW7d7PHB6iVFQCtz9wwk9WZ21_rL0888uygth6eg2uxXzyeSg_4477Bo0d9mNfsLkr3vs1XH7M6nPQ5LddEntk8P3Jwkmqokjda-Tc-gMJoi-9q_vsy9Hhydvj9M4HwGRVEWXqtxUrjCoA8PVrBJVbizFe8x5LPql5RbTDSusUQXYyhTg5iBBwYIvcmUwj3rAJk3bwA5LSietKo2ErJRYA1VmhlJYNZeFMMJWMGV8C5B2kTycZlic6XAjJrCI6L9XE6w6wjpl6fDWqifPuEL-DWE_yBL1dXiABqGjQeirDGLKnpPmNJFbNNQ9881svNfvPnzVB0LmUgieq78JfV7-i9CnkdDLKFS1iIgz8bcGxJWYtUaSuyNJ9GM3Wt4hU9sC4xGUAk1XSLnAN7fmd_nys2GZNqW2uQbajdfoBlxliAru_rC31gFcjmc53bpPmRzZ8Qj98UpTfw8E5NlMEqelfPQ_9PWY3Zyj9kMnvNhlk269gSfsuvvR1X79NLj1b_ExT3c
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Biological Science Database
  dbid: M7P
  link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwELdGBxIvfG8rDBQQEg8oW1M3sf00DbRpPFAmGGhvlu04W6QtKXUK2n-_O8cNZBoDidf6EjX35d_Fl98R8jq3As81VUzBwPEE9sxYwS4Rm0xbgB-GJ6n2wybYdMqPj8VheOHmQlvlMif6RJ3XBt-RbwO0hcoCCrbJzux7jFOj8HQ1jNC4RVaRJWHsW_cOu4JrLPxsVSScgaBmNHw6R1myHSy1NdNlvUU9sxfrbU2ewb_L04PZWe2uA6FXeyl_25z27__vYz0g9wIsjXZbP3pIVmz1iNxpB1VePCZvD-qfUXnusXrVRKWL9j4eRYB3I4NeM4_ObaMAZ7rS7TwhX_f3jt4fxGHMAhhEZE0sUlWYTIEpFRWjghWp0ggbADppCG9NNaAWzbQSmdWFyqwZW26FndBJKhTAsTUyqOrKbpAoN1yLXHGb5BxKqUKNQAqK7zxjiunCDgldaliawEGOozDOpD9YY1CLtM8r0S4y2GVI4u6qWcvB8Rf5d2i8ThYZtP0P9fxEhoCUWltqEsuLXEAes0ohEhMsp5nmlI_SIXmFppfIkVFhE86JWjgnP3z6JncZTzljNBV_Evoy_Rehzz2hN0GoqEEjRoWvI0CvSNDVk9zsSUI6ML3lDfTVpWKc_OVhcOXSB69fftkt402x-66y9cJJiCMqEtAK3H29dfdOuRS2BDy8HxLeC4Se9vsrVXnqecyTEUdqTP705v_1jNwdg119qzzbJINmvrDPyW3zoynd_IWP-Ev25V2C
  priority: 102
  providerName: ProQuest
Title How important is EMT for cancer metastasis?
URI https://www.ncbi.nlm.nih.gov/pubmed/38324529
https://www.proquest.com/docview/3069177884
https://www.proquest.com/docview/2923913809
https://pubmed.ncbi.nlm.nih.gov/PMC10849258
https://doaj.org/article/bbe3c1e8fd9040eaa584697d36b83805
http://dx.doi.org/10.1371/journal.pbio.3002487
Volume 22
WOSCitedRecordID wos001163891900001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVAON
  databaseName: DOAJ Directory of Open Access Journals
  customDbUrl:
  eissn: 1545-7885
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0022928
  issn: 1545-7885
  databaseCode: DOA
  dateStart: 20030101
  isFulltext: true
  titleUrlDefault: https://www.doaj.org/
  providerName: Directory of Open Access Journals
– providerCode: PRVPQU
  databaseName: Biological Science Database
  customDbUrl:
  eissn: 1545-7885
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0022928
  issn: 1545-7885
  databaseCode: M7P
  dateStart: 20031001
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/biologicalscijournals
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Environmental Science Database
  customDbUrl:
  eissn: 1545-7885
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0022928
  issn: 1545-7885
  databaseCode: PATMY
  dateStart: 20031001
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/environmentalscience
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Health & Medical Collection
  customDbUrl:
  eissn: 1545-7885
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0022928
  issn: 1545-7885
  databaseCode: 7X7
  dateStart: 20031001
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthcomplete
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Central
  customDbUrl:
  eissn: 1545-7885
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0022928
  issn: 1545-7885
  databaseCode: BENPR
  dateStart: 20031001
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Publicly Available Content Database
  customDbUrl:
  eissn: 1545-7885
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0022928
  issn: 1545-7885
  databaseCode: PIMPY
  dateStart: 20031001
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/publiccontent
  providerName: ProQuest
– providerCode: PRVATS
  databaseName: Public Library of Science (PLoS) Journals Open Access
  customDbUrl:
  eissn: 1545-7885
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0022928
  issn: 1545-7885
  databaseCode: FPL
  dateStart: 20030101
  isFulltext: true
  titleUrlDefault: http://www.plos.org/publications/
  providerName: Public Library of Science
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3db9MwELdYBxIv45sVRhQQEg8oWxM3_nhCG2q1SaxEY6DyZNmOwyJtSdWkIP57zk4ayLQKeMlD7hylv7uzf1dfzgi9Tg23-5oywGDgYAxrZiBhlQg0UQboh2ZhrNxhE3Q2Y_M5T34nitd28DEND1pM9xcqL_ex68FFt9B2hAmxydY0-dAlWBGPWPt53KaRveXHdenv5uLB4rKsbiKa1-sl_1iApvf-99Xvo52WavqHjW88QLdM8RDdaQ6f_PkIvT0uf_j5lePfRe3nlT85PfeBw_raesLSvzK1BO5Y5dW7x-jzdHL-_jhoj04AkDmpAx7LTBMJ5pGYjzKaxVJZKgB0SEHIKqyAiSiqJCdGZZIYHRlmuBnjccwlUKwnaFCUhdlFfqqZ4qlkJkwZpEeZHIEWJNQpoZKqzAwRXiMqdNtX3B5vcSncZhmF_KL5vcLCIFoYhijoRi2avhp_0T-yxup0bVdsdwPwFm2QCaUM1qFhWcphbjJSWnbFaYqJYpiN4iF6ZU0tbN-LwhbWfJOrqhInH7-IQ8piRimO-SalT7N_UTrrKb1plbISENGy_eIBcLVNt3qaez1NCHHdE-9a31wDUwEoBNJsytgYRq799Wbxy05sH2or6gpTrioBsYJ5CKjA05827t2Bi2GatxvyQ8R6jt9Dvy8p8gvXmzwcMdvukj3b_MrP0d0IbOpK3-keGtTLlXmBbuvvdV4tPbRF59RdmYe2jyaz5Mxzf5R4LtY9W5ybgCQ5OU2-_gIFLlDT
linkProvider Public Library of Science
linkToHtml http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1bb9MwFLamDgQv3GGFAQGBeEDZmjiJ7Qc0DdjUamupoKDxZGzHGZG2pDQt0_4Uv5FzkjQQNC4ve-C1Pknd4-_cavs7hDyJrcB9TeVSWGA3gJjpKogSrom0hfTDcC_UZbMJNhrxgwMxXiHflndh8Fjl0ieWjjrODf5HvgmpLVQWULAFW9MvLnaNwt3VZQuNChZ79vQESrbixeA1rO9T39_dmbzqu3VXAfh-Ec1dEarERApmrqDeT1gSKo1REjIFDWjWVEOQ1kwrEVmdqMga33IrbECDUKgAiQ7A5a8GCPYOWR0PhuOPTYnni7KbK1LcgBthtL6sR5m3WWNjY6rTfIOWXGKsFQzLngFNZOhMj_LirLT319ObP4XD3av_myKvkSt14u1sV5ZynazY7Aa5WLXiPL1JnvfzEyc9LquRbO6khbMznDiQ0TsG7WLmHNu5gky6SIutW-T9ucz0NulkeWbXiBMbrkWsuPViDsVionogxQI_jphiOrFdQpcrKk3Nso7NPo5kuXXIoNqqfq9EHMgaB13iNk9NK5aRv8i_RLA0ssgRXn6Qzw5l7XKk1pYaz_IkFuCprVKYawoW00hzynthlzxGqElkAcnwmNGhWhSFHLz5ILcZDzljNBS_E3o3-hehty2hZ7VQkoNGjKrvf4BekYKsJbnekgSHZ1rDa2gbS8UU8gei4ckl5s8eftQM40vxfGFm80UhwW6p8EAr8PY7lXk1yqUQ9PB4QpfwluG1tN8eydLPJVO71-NI_snv_nleD8ml_mS4L_cHo7175LIPa1xeDGDrpDOfLex9csF8nafF7EHtbxzy6bwt8ztnf74l
linkToPdf http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwELaqLSAuvKELBQICcUDpbuIktg-oKrRVV6XLCgoqJ2M7TonUJstml6p_jV_HTF4QVB6XHriuJ5Ez_ua1tr8h5ElsBe5rKpfCArsBxExXQZRwTaQtpB-Ge6Eum02w8ZgfHIjJEvnW3IXBY5WNTywddZwb_I98AKktVBZQsAWDpD4WMdncXp9-cbGDFO60Nu00Kojs2tMTKN-KF6NNWOunvr-9tf9qx607DMBcRDR3RagSEyn4CgW1f8KSUGmMmJA1aEC2phoCtmZaicjqREXW-JZbYQMahEIFSHoA7n8ZUvLA75HlyWhv8rEt93xRdnZFuhtwKYzWF_co8wY1TtamOs3XaMkrxjqBsewf0EaJ3vQoL85KgX89yflTaNy--j8r9Rq5UifkzkZlQdfJks1ukItVi87Tm-T5Tn7ipMdllZLNnbRwtvb2Hcj0HYP2MnOO7VxBhl2kxfot8v5cZnqb9LI8syvEiQ3XIlbcejGHIjJRQ5ACVMQRU0wntk9os7rS1Ozr2ATkSJZbigyqsOp7JWJC1pjoE7d9alqxj_xF_iUCp5VF7vDyh3x2KGtXJLW21HiWJ7EAD26VwhxUsJhGmlM-DPvkMcJOIjtIhpA4VIuikKM3H-QG4yFnjIbid0Lvxv8i9LYj9KwWSnLQiFH1vRDQK1KTdSRXO5LgCE1neAXtpFFMIX-gG55s8H_28KN2GF-K5w4zmy8KCTZMhQdagbffqUytVS6FYIjHFvqEd4ywo_3uSJZ-LhncvSFHUlB-98_zekgugTnK16Px7j1y2YclLu8LsFXSm88W9j65YL7O02L2oHY9Dvl03ob5HTywxuU
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=How+important+is+EMT+for+cancer+metastasis%3F&rft.jtitle=PLoS+biology&rft.au=Celi%C3%A0-Terrassa%2C+Toni&rft.au=Kang%2C+Yibin&rft.date=2024-02-07&rft.pub=Public+Library+of+Science&rft.issn=1544-9173&rft.volume=22&rft.issue=2&rft_id=info:doi/10.1371%2Fjournal.pbio.3002487&rft.externalDBID=ISR&rft.externalDocID=A785877359
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1545-7885&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1545-7885&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1545-7885&client=summon