Characterizing steroid hormone receptor chromatin binding landscapes in male and female breast cancer

Male breast cancer (MBC) is rare and poorly characterized. Like the female counterpart, most MBCs are hormonally driven, but relapse after hormonal treatment is also noted. The pan-hormonal action of steroid hormonal receptors, including estrogen receptor alpha (ERα), androgen receptor (AR), progest...

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Bibliographic Details
Published in:Nature communications Vol. 9; no. 1; pp. 482 - 12
Main Authors: Severson, Tesa M., Kim, Yongsoo, Joosten, Stacey E. P., Schuurman, Karianne, van der Groep, Petra, Moelans, Cathy B., ter Hoeve, Natalie D., Manson, Quirine F., Martens, John W., van Deurzen, Carolien H. M., Barbe, Ellis, Hedenfalk, Ingrid, Bult, Peter, Smit, Vincent T. H. B. M., Linn, Sabine C., van Diest, Paul J., Wessels, Lodewyk, Zwart, Wilbert
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 02.02.2018
Nature Publishing Group
Nature Portfolio
Subjects:
38/15
38/23
38/39
45/91
631/208/69
631/67/1347
692/53/2422
Adult
Aged
Aged, 80 and over
Androgen receptors
Androgens
Binding
Breast cancer
Breast Neoplasms - metabolism
Breast Neoplasms, Male - metabolism
Cancer
Cancer and Oncology
Cancer och onkologi
Chromatin
Chromatin - metabolism
Clinical Medicine
Crosstalk
Estrogen Receptor alpha - metabolism
Estrogens
Female
GATA-3 protein
GATA3 Transcription Factor - metabolism
Gene expression
Genomes
Glucocorticoids
Hepatocyte Nuclear Factor 3-alpha - metabolism
Humanities and Social Sciences
Humans
Klinisk medicin
Male
Medical and Health Sciences
Medicin och hälsovetenskap
Mens health
Middle Aged
multidisciplinary
Progesterone
Receptors
Receptors, Androgen - metabolism
Receptors, Glucocorticoid - metabolism
Receptors, Progesterone - metabolism
Science
Science (multidisciplinary)
Steroids
Survival Rate
Tumors
ISSN:2041-1723, 2041-1723
Online Access:Get full text
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Summary:Male breast cancer (MBC) is rare and poorly characterized. Like the female counterpart, most MBCs are hormonally driven, but relapse after hormonal treatment is also noted. The pan-hormonal action of steroid hormonal receptors, including estrogen receptor alpha (ERα), androgen receptor (AR), progesterone receptor (PR), and glucocorticoid receptor (GR) in this understudied tumor type remains wholly unexamined. This study reveals genomic cross-talk of steroid hormone receptor action and interplay in human tumors, here in the context of MBC, in relation to the female disease and patient outcome. Here we report the characterization of human breast tumors of both genders for cistromic make-up of hormonal regulation in human tumors, revealing genome-wide chromatin binding landscapes of ERα, AR, PR, GR, FOXA1, and GATA3 and enhancer-enriched histone mark H3K4me1. We integrate these data with transcriptomics to reveal gender-selective and genomic location-specific hormone receptor actions, which associate with survival in MBC patients. Male breast cancer (MBC) is rare and largely hormonally driven. Here, the authors examine the action of steroid hormone receptors in male and female breast cancers and find gender selective hormone receptor action that associates with the survival of MBC patients.
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ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-018-02856-2