Inducing and exploiting vulnerabilities for the treatment of liver cancer

Liver cancer remains difficult to treat, owing to a paucity of drugs that target critical dependencies 1 , 2 ; broad-spectrum kinase inhibitors such as sorafenib provide only a modest benefit to patients with hepatocellular carcinoma 3 . The induction of senescence may represent a strategy for the t...

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Bibliographic Details
Published in:	Nature (London) Vol. 574; no. 7777; pp. 268 - 272
Main Authors:	Wang, Cun, Vegna, Serena, Jin, Haojie, Benedict, Bente, Lieftink, Cor, Ramirez, Christel, de Oliveira, Rodrigo Leite, Morris, Ben, Gadiot, Jules, Wang, Wei, du Chatinier, Aimée, Wang, Liqin, Gao, Dongmei, Evers, Bastiaan, Jin, Guangzhi, Xue, Zheng, Schepers, Arnout, Jochems, Fleur, Sanchez, Antonio Mulero, Mainardi, Sara, te Riele, Hein, Beijersbergen, Roderick L., Qin, Wenxin, Akkari, Leila, Bernards, René
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.10.2019 Nature Publishing Group
Subjects:	13 13/1 13/106 13/44 14 59 59/57 631/67/1059/602 631/67/68 Activation Aging Analysis Animal models Animals Antidepressants Apoptosis Apoptosis - drug effects Cancer therapies Care and treatment Cell Cycle Proteins - antagonists & inhibitors Cell death Cell Line, Tumor Cellular Senescence - drug effects Deoxyribonucleic acid Disease Models, Animal DNA DNA biosynthesis Female Genetic screening Hepatocellular carcinoma Hepatocytes Humanities and Social Sciences Inhibitors Kinases Letter Liver Liver cancer Liver Neoplasms - drug therapy Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Male Mice Mice, Inbred BALB C Molecular Targeted Therapy multidisciplinary Mutation Organic chemistry p53 Protein Physiological aspects Protein Serine-Threonine Kinases - antagonists & inhibitors Science Science (multidisciplinary) Senescence Sertraline Sertraline - pharmacology Sertraline - therapeutic use Signal transduction Signal Transduction - drug effects Signaling TOR protein TOR Serine-Threonine Kinases - antagonists & inhibitors Tumor Suppressor Protein p53 - genetics Tumors China
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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