A new test suggests hundreds of amino acid polymorphisms in humans are subject to balancing selection

The role that balancing selection plays in the maintenance of genetic diversity remains unresolved. Here, we introduce a new test, based on the McDonald–Kreitman test, in which the number of polymorphisms that are shared between populations is contrasted to those that are private at selected and neu...

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Bibliographic Details
Published in:	PLoS biology Vol. 20; no. 6; p. e3001645
Main Authors:	Soni, Vivak, Vos, Michiel, Eyre-Walker, Adam
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 02.06.2022 Public Library of Science (PLoS)
Subjects:	Amino acids Balancing Biology and Life Sciences Evolution & development Genetic aspects Genetic diversity Genetic polymorphisms Methods and Resources Mutation Physiological aspects Polymorphism Population Quantitative genetics Research and Analysis Methods Simulation United Kingdom
ISSN:	1545-7885, 1544-9173, 1545-7885
Online Access:	Get full text
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