Antimicrobial Resistance: Addressing a Global Threat to Humanity

In a systematic review of 109 studies reporting bloodstream infections in hospitalized patients from LMICs, several WHO critical and high priority pathogens were associated with increased mortality, length of hospital stay and admission to intensive care units (ICU), and cost [12]. To gain a better...

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Veröffentlicht in:PLoS medicine Jg. 20; H. 7; S. e1004264
Hauptverfasser: Walsh, Timothy R., Gales, Ana C., Laxminarayan, Ramanan, Dodd, Philippa C.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Public Library of Science 03.07.2023
Public Library of Science (PLoS)
Schlagworte:
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Antibiotics
Antimicrobial agents
Antimicrobial resistance
Bacteria
Biology and Life Sciences
Colonization
Communicable diseases
COVID-19
COVID-19 vaccines
Disease control
Disease transmission
Drug resistance
Drug resistance in microorganisms
Drug Resistance, Bacterial
Earth Sciences
Global Health
Hospitals
Humans
Hygiene
Immunization
Intensive care units
Management
Mathematical models
Medicine and Health Sciences
Mortality
Pathogens
Patients
Pediatrics
Population levels
Prevention
Public health
Risk factors
Sepsis
Social Sciences
Staphylococcus infections
Systematic review
United States
Africa
ISSN:1549-1676, 1549-1277, 1549-1676
Online-Zugang:Volltext
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Zusammenfassung:In a systematic review of 109 studies reporting bloodstream infections in hospitalized patients from LMICs, several WHO critical and high priority pathogens were associated with increased mortality, length of hospital stay and admission to intensive care units (ICU), and cost [12]. To gain a better understanding of the relationship between treatment duration and prevalence of colonization with antimicrobial resistant bacteria in hospitalized patients, Yin Mo and co-workers applied a model to assess how changing duration of antibiotic treatment would affect the risk of resistance colonization at both individual and population levels [14]. The authors concluded that shortening antibiotic treatment duration may increase or decrease colonization by resistant bacteria, dependent upon individual and combined bacterial and antibiotic characteristics [14]. Using a novel mathematical modeling approach, David Smith and colleagues reported that surges in COVID-19 cases fostered conditions favorable for bacterial transmission, on average resulting in a 14% increase in colonization and a 10% increase in rates of AMR [15].
Bibliographie:SourceType-Scholarly Journals-1
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I have read the journal’s policy and the authors of this manuscript have the following competing interests: TW, AG and RL are Guest Editors for PLOS Medicine’s Special Issue. PD is an Associate Editor at PLOS Medicine.
ISSN:1549-1676
1549-1277
1549-1676
DOI:10.1371/journal.pmed.1004264