Antimicrobial Resistance: Addressing a Global Threat to Humanity

In a systematic review of 109 studies reporting bloodstream infections in hospitalized patients from LMICs, several WHO critical and high priority pathogens were associated with increased mortality, length of hospital stay and admission to intensive care units (ICU), and cost [12]. To gain a better...

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Vydané v:	PLoS medicine Ročník 20; číslo 7; s. e1004264
Hlavní autori:	Walsh, Timothy R., Gales, Ana C., Laxminarayan, Ramanan, Dodd, Philippa C.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Public Library of Science 03.07.2023 Public Library of Science (PLoS)
Predmet:	Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Antibiotics Antimicrobial agents Antimicrobial resistance Bacteria Biology and Life Sciences Colonization Communicable diseases COVID-19 COVID-19 vaccines Disease control Disease transmission Drug resistance Drug resistance in microorganisms Drug Resistance, Bacterial Earth Sciences Global Health Hospitals Humans Hygiene Immunization Intensive care units Management Mathematical models Medicine and Health Sciences Mortality Pathogens Patients Pediatrics Population levels Prevention Public health Risk factors Sepsis Social Sciences Staphylococcus infections Systematic review United States Africa
ISSN:	1549-1676, 1549-1277, 1549-1676
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Popis
Shrnutí:	In a systematic review of 109 studies reporting bloodstream infections in hospitalized patients from LMICs, several WHO critical and high priority pathogens were associated with increased mortality, length of hospital stay and admission to intensive care units (ICU), and cost [12]. To gain a better understanding of the relationship between treatment duration and prevalence of colonization with antimicrobial resistant bacteria in hospitalized patients, Yin Mo and co-workers applied a model to assess how changing duration of antibiotic treatment would affect the risk of resistance colonization at both individual and population levels [14]. The authors concluded that shortening antibiotic treatment duration may increase or decrease colonization by resistant bacteria, dependent upon individual and combined bacterial and antibiotic characteristics [14]. Using a novel mathematical modeling approach, David Smith and colleagues reported that surges in COVID-19 cases fostered conditions favorable for bacterial transmission, on average resulting in a 14% increase in colonization and a 10% increase in rates of AMR [15].
Bibliografia:	SourceType-Scholarly Journals-1 content type line 14 ObjectType-Editorial-2 ObjectType-Commentary-1 content type line 23 I have read the journal’s policy and the authors of this manuscript have the following competing interests: TW, AG and RL are Guest Editors for PLOS Medicine’s Special Issue. PD is an Associate Editor at PLOS Medicine.
ISSN:	1549-1676 1549-1277 1549-1676
DOI:	10.1371/journal.pmed.1004264