Inferring the immune response from repertoire sequencing

High-throughput sequencing of B- and T-cell receptors makes it possible to track immune repertoires across time, in different tissues, and in acute and chronic diseases or in healthy individuals. However, quantitative comparison between repertoires is confounded by variability in the read count of e...

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Bibliographic Details
Published in:	PLoS computational biology Vol. 16; no. 4; p. e1007873
Main Authors:	Puelma Touzel, Maximilian, Walczak, Aleksandra M., Mora, Thierry
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.04.2020 PLOS Public Library of Science (PLoS)
Subjects:	Adaptive immunology B cells Bayes Theorem Bayesian analysis Biology and Life Sciences Chronic illnesses Computational Biology DNA sequencing Frequency distribution Genetic aspects High-throughput screening (Biochemical assaying) Humans Immune response Immune system Immunology Life Sciences Lymphocytes T Medicine and Health Sciences Methods Models, Immunological Next-generation sequencing Noise Quantitative Methods Receptors Receptors, Antigen, B-Cell - genetics Receptors, Antigen, B-Cell - immunology Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - immunology Research and Analysis Methods RNA-Seq - methods Stochasticity T cells Transcriptome - immunology Vaccination Vaccines Vector-borne diseases Yellow fever Yellow Fever Vaccine - immunology Canada France RNA sequencing Immune response Lymphocytes Cloning Mathematical models Gene expression Vaccination and immunization Yellow fever
ISSN:	1553-7358, 1553-734X, 1553-7358
Online Access:	Get full text
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